PMID- 36067801
OWN - NLM
STAT- MEDLINE
DCOM- 20230126
LR  - 20230209
IS  - 1553-4014 (Electronic)
IS  - 1553-4006 (Linking)
VI  - 18
DP  - 2023 Jan 24
TI  - The Immunobiology and Pathogenesis of Celiac Disease.
PG  - 47-70
LID - 10.1146/annurev-pathmechdis-031521-032634 [doi]
AB  - Among human leukocyte antigen (HLA)-associated disorders, celiac disease has an 
      immunopathogenesis that is particularly well understood. The condition is 
      characterized by hypersensitivity to cereal gluten proteins, and the disease 
      lesion is localized in the gut. Still, the diagnosis can be made by detection of 
      highly disease-specific autoantibodies to transglutaminase 2 in the blood. We now 
      have mechanistic insights into how the disease-predisposing HLA-DQ molecules, via 
      presentation of posttranslationally modified gluten peptides, are connected to 
      the generation of these autoantibodies. This review presents our current 
      understanding of the immunobiology of this common disorder that is positioned in 
      the border zone between food hypersensitivity and autoimmunity.
FAU - Iversen, Rasmus
AU  - Iversen R
AD  - KG Jebsen Coeliac Disease Research Centre, Institute of Clinical Medicine, 
      University of Oslo, Oslo, Norway; email: l.m.sollid@medisin.uio.no.
AD  - Department of Immunology, Oslo University Hospital-Rikshospitalet, Oslo, Norway.
FAU - Sollid, Ludvig M
AU  - Sollid LM
AD  - KG Jebsen Coeliac Disease Research Centre, Institute of Clinical Medicine, 
      University of Oslo, Oslo, Norway; email: l.m.sollid@medisin.uio.no.
AD  - Department of Immunology, Oslo University Hospital-Rikshospitalet, Oslo, Norway.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20220906
PL  - United States
TA  - Annu Rev Pathol
JT  - Annual review of pathology
JID - 101275111
RN  - EC 2.3.2.13 (Transglutaminases)
RN  - 8002-80-0 (Glutens)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (Autoantibodies)
SB  - IM
MH  - Humans
MH  - *Celiac Disease/diagnosis/genetics
MH  - Transglutaminases
MH  - Glutens/adverse effects
MH  - HLA-DQ Antigens/genetics
MH  - Autoantibodies
OTO - NOTNLM
OT  - B cells
OT  - HLA
OT  - T cells
OT  - autoimmunity
OT  - celiac disease
OT  - gluten
OT  - transglutaminase 2
EDAT- 2022/09/07 06:00
MHDA- 2023/01/27 06:00
CRDT- 2022/09/06 19:12
PHST- 2022/09/07 06:00 [pubmed]
PHST- 2023/01/27 06:00 [medline]
PHST- 2022/09/06 19:12 [entrez]
AID - 10.1146/annurev-pathmechdis-031521-032634 [doi]
PST - ppublish
SO  - Annu Rev Pathol. 2023 Jan 24;18:47-70. doi: 
      10.1146/annurev-pathmechdis-031521-032634. Epub 2022 Sep 6.