PMID- 36071823
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220910
IS  - 2673-3080 (Electronic)
IS  - 2673-3080 (Linking)
VI  - 4
DP  - 2022
TI  - Chronic atrazine exposure increases the expression of genes associated with 
      GABAergic and glutamatergic systems in the brain of male albino rat.
PG  - 933300
LID - 10.3389/ftox.2022.933300 [doi]
LID - 933300
AB  - The herbicide atrazine (ATR; 2-chloro-4-ethylamino-6-isopropylamino-s-triazine) 
      is widely used to destroy grasses and broadleaf weeds in crops and some fruits. 
      Studies in rodents have shown that acute, repeated or chronic exposure to ATR is 
      associated with alterations in the nigrostriatal dopaminergic pathway, whereas 
      its effects on GABAergic and glutamatergic pathways have only recently been 
      reported. Sprague-Dawley male rats were exposed daily to 1 or 10 mg ATR/kg of BW 
      for 13 months to evaluate the ATR effects on GABAergic and glutamatergic systems. 
      At the end of the ATR treatment, the levels of mRNA of several genes involved in 
      the production, vesiculation, reuptake, and receptors of GABA and Glu in the 
      striatum (STR), nucleus accumbens (NAcc), prefrontal cortex (PFC), ventral 
      midbrain (vMID) and hippocampus (HIPP) were evaluated by absolute qPCR. For the 
      GABAergic genes, increased expression of GAD67 and Slc32a1 in STR and/or vMID in 
      rats exposed to 1 and/or 10 mg ATR were detected. With regard to the expression 
      of genes involved in the glutamatergic system, Slc17a6 and Grin1 in HIPP of rats 
      exposed to 1 and/or 10 mg ATR, increased as was Gria1 in STR and PFC in the group 
      exposed to 1 mg ATR. In the same fashion, Slc1a3 expression and MGLUR1 increased 
      in STR of rats exposed to 1 and 10 mg ATR groups. The expression of the 
      glutaminases gls (variants 1 and 2) was greater in STR, NAcc, HIPP, and PFC of 
      rats exposed to 1 and/or 10 mg ATR. These findings show that the GABAergic and, 
      especially glutamatergic systems are targets of ATR exposure.
CI  - Copyright (c) 2022 Reyes-Bravo, Villalobos-Aguilera, Almonte-Zepeda, Mendoza-Trejo, 
      Giordano, Orozco and Rodriguez.
FAU - Reyes-Bravo, D Y
AU  - Reyes-Bravo DY
AD  - Departamento de Neurobiologia Conductual y Cognitiva, Instituto de Neurobiologia, 
      Universidad Nacional Autonoma de Mexico, Queretaro, Mexico.
FAU - Villalobos-Aguilera, P
AU  - Villalobos-Aguilera P
AD  - Departamento de Neurobiologia Celular y Molecular, Instituto de Neurobiologia, 
      Universidad Nacional Autonoma de Mexico, Queretaro, Mexico.
FAU - Almonte-Zepeda, J T
AU  - Almonte-Zepeda JT
AD  - Departamento de Neurobiologia Conductual y Cognitiva, Instituto de Neurobiologia, 
      Universidad Nacional Autonoma de Mexico, Queretaro, Mexico.
FAU - Mendoza-Trejo, M S
AU  - Mendoza-Trejo MS
AD  - Departamento de Neurobiologia Conductual y Cognitiva, Instituto de Neurobiologia, 
      Universidad Nacional Autonoma de Mexico, Queretaro, Mexico.
FAU - Giordano, M
AU  - Giordano M
AD  - Departamento de Neurobiologia Conductual y Cognitiva, Instituto de Neurobiologia, 
      Universidad Nacional Autonoma de Mexico, Queretaro, Mexico.
FAU - Orozco, A
AU  - Orozco A
AD  - Departamento de Neurobiologia Celular y Molecular, Instituto de Neurobiologia, 
      Universidad Nacional Autonoma de Mexico, Queretaro, Mexico.
FAU - Rodriguez, V M
AU  - Rodriguez VM
AD  - Departamento de Neurobiologia Conductual y Cognitiva, Instituto de Neurobiologia, 
      Universidad Nacional Autonoma de Mexico, Queretaro, Mexico.
LA  - eng
PT  - Journal Article
DEP - 20220822
PL  - Switzerland
TA  - Front Toxicol
JT  - Frontiers in toxicology
JID - 101777990
PMC - PMC9441881
OTO - NOTNLM
OT  - GABA
OT  - albino rat
OT  - glutamate
OT  - herbicides
OT  - mRNA expression
OT  - neurodegenenerative diseases
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/09/09 06:00
MHDA- 2022/09/09 06:01
PMCR- 2022/08/22
CRDT- 2022/09/08 02:15
PHST- 2022/04/30 00:00 [received]
PHST- 2022/07/19 00:00 [accepted]
PHST- 2022/09/08 02:15 [entrez]
PHST- 2022/09/09 06:00 [pubmed]
PHST- 2022/09/09 06:01 [medline]
PHST- 2022/08/22 00:00 [pmc-release]
AID - 933300 [pii]
AID - 10.3389/ftox.2022.933300 [doi]
PST - epublish
SO  - Front Toxicol. 2022 Aug 22;4:933300. doi: 10.3389/ftox.2022.933300. eCollection 
      2022.