PMID- 36071945
OWN - NLM
STAT- MEDLINE
DCOM- 20220909
LR  - 20220922
IS  - 1918-1523 (Electronic)
IS  - 1203-6765 (Print)
IS  - 1203-6765 (Linking)
VI  - 2022
DP  - 2022
TI  - Pain Sensitization and Neuropathic Pain-like Symptoms Associated with 
      Effectiveness of Exercise Therapy in Patients with Hip and Knee Osteoarthritis.
PG  - 4323045
LID - 10.1155/2022/4323045 [doi]
LID - 4323045
AB  - Pain sensitization and neuropathic pain-like symptoms are some of the common pain 
      symptoms in patients with lower limbs, including hip and knee, osteoarthritis 
      (HOA/KOA). Exercise therapy has been the first-line treatment; however, the 
      effects differ for each patient. This prospective cohort study investigated the 
      relationship between the effectiveness of exercise therapy and pretreatment 
      characteristics (radiologic severity, pain sensitization, and neuropathic 
      pain-like symptoms) of patients with HOA/KOA. We assessed the pain intensity 
      using a numerical rating scale (NRS) before and after 12 weeks of exercise 
      therapy in patients with HOA/KOA (n = 101). Before treatment, the 
      Kellgren-Lawrence (K-L) grade; minimum joint space width (mJSW); pressure pain 
      threshold (PPT) and temporal summation of pain (TSP) at the affected joint, 
      tibia, and forearm; Central Sensitization Inventory-9; and painDETECT 
      questionnaire (PDQ) were assessed. Cluster analysis was based on the pretreatment 
      NRS and change in NRS with exercise therapy to identify the subgroups of pain 
      reduction. The pretreatment characteristics of each cluster were compared. 
      According to the results of the cluster analyses, patients in cluster 1 had 
      severe pain that did not improve after exercise therapy, patients in cluster 2 
      had severe pain that improved, and those in cluster 3 had mild pain that 
      improved. The patients in cluster 1 exhibited lower PPT at all measurement sites, 
      higher TSP at the affected joint, and higher PDQ scores than those in other 
      clusters. There was no difference in the K-L grade and mJSW among the clusters. 
      The subgroup with severe pain and pain sensitization or neuropathic pain-like 
      symptoms at pretreatment, even with mild joint deformity, may have difficulty in 
      achieving improvement in pain after 12 weeks of exercise therapy. These findings 
      could be useful for prognosis prediction and for planning exercise therapy and 
      combining with other treatment.
CI  - Copyright (c) 2022 Takafumi Hattori et al.
FAU - Hattori, Takafumi
AU  - Hattori T
AUID- ORCID: 0000-0002-8885-2560
AD  - Faculty of Rehabilitation, Kobe Gakuin University Graduate School, Kobe, Hyogo, 
      Japan.
AD  - Department of Rehabilitation, Maehara Orthopedics Rehabilitation Clinic, Obu, 
      Aichi, Japan.
FAU - Shimo, Kazuhiro
AU  - Shimo K
AUID- ORCID: 0000-0002-8575-6186
AD  - Department of Physical Therapy, Faculty of Rehabilitation, Kobe Gakuin 
      University, Kobe, Hyogo, Japan.
FAU - Niwa, Yuto
AU  - Niwa Y
AUID- ORCID: 0000-0001-9440-1865
AD  - Faculty of Rehabilitation, Kobe Gakuin University Graduate School, Kobe, Hyogo, 
      Japan.
FAU - Katsura, Yuichi
AU  - Katsura Y
AUID- ORCID: 0000-0003-0449-6034
AD  - Faculty of Rehabilitation, Kobe Gakuin University Graduate School, Kobe, Hyogo, 
      Japan.
FAU - Tokiwa, Yuji
AU  - Tokiwa Y
AD  - Faculty of Rehabilitation, Kobe Gakuin University Graduate School, Kobe, Hyogo, 
      Japan.
FAU - Ohga, Satoshi
AU  - Ohga S
AUID- ORCID: 0000-0001-6802-7726
AD  - Department of Physical Therapy, Faculty of Rehabilitation, Kobe Gakuin 
      University, Kobe, Hyogo, Japan.
FAU - Matsubara, Takako
AU  - Matsubara T
AUID- ORCID: 0000-0002-8849-3596
AD  - Faculty of Rehabilitation, Kobe Gakuin University Graduate School, Kobe, Hyogo, 
      Japan.
AD  - Department of Physical Therapy, Faculty of Rehabilitation, Kobe Gakuin 
      University, Kobe, Hyogo, Japan.
LA  - eng
PT  - Journal Article
DEP - 20220829
PL  - United States
TA  - Pain Res Manag
JT  - Pain research & management
JID - 9612504
SB  - IM
MH  - Exercise Therapy
MH  - Humans
MH  - Knee
MH  - *Neuralgia/complications/therapy
MH  - *Osteoarthritis, Hip/complications/therapy
MH  - *Osteoarthritis, Knee/complications/therapy
MH  - Prospective Studies
PMC - PMC9444422
COIS- The authors declare that they have no conflicts of interest.
EDAT- 2022/09/09 06:00
MHDA- 2022/09/11 06:00
PMCR- 2022/08/29
CRDT- 2022/09/08 02:17
PHST- 2022/03/05 00:00 [received]
PHST- 2022/07/21 00:00 [revised]
PHST- 2022/08/12 00:00 [accepted]
PHST- 2022/09/08 02:17 [entrez]
PHST- 2022/09/09 06:00 [pubmed]
PHST- 2022/09/11 06:00 [medline]
PHST- 2022/08/29 00:00 [pmc-release]
AID - 10.1155/2022/4323045 [doi]
PST - epublish
SO  - Pain Res Manag. 2022 Aug 29;2022:4323045. doi: 10.1155/2022/4323045. eCollection 
      2022.