PMID- 36073532
OWN - NLM
STAT- MEDLINE
DCOM- 20221115
LR  - 20221115
IS  - 1348-0421 (Electronic)
IS  - 0385-5600 (Linking)
VI  - 66
IP  - 11
DP  - 2022 Nov
TI  - Human herpesvirus 6A and 6B and polyomavirus JC and BK infections in renal cell 
      carcinoma and their relationship with p53, p16INK4a, Ki-67, and nuclear 
      factor-kappa B expression.
PG  - 510-518
LID - 10.1111/1348-0421.13026 [doi]
AB  - There are a limited number of studies regarding the involvement of viruses in the 
      development and pathogenesis of renal cell carcinoma (RCC). In this study, we 
      aimed to discover whether human herpesvirus 6A (HHV-6A) and 6B (HHV-6B) and human 
      polyomavirus JC (JCV) and BK (BKV) are associated with RCC and the expression of 
      p53, p16INK4a, Ki-67, and nuclear factor-kappaB (NF-kappaB) in patients with RCC. A total 
      of 122 histologically confirmed RCC tissue specimens and 96 specimens of their 
      corresponding peritumoral tissues were included in this prospective study. Nested 
      PCR was performed to amplify viral DNA sequences. Restriction endonuclease 
      analysis was carried out to discriminate between HHV-6A and HHV-6B. p53, 
      p16INK4a, Ki-67, and NF-kappaB immunostaining data of the studied tissue specimens 
      were available from our previous study. Statistical analysis was performed to 
      demonstrate the potential associations. HHV-6B and JCV were detected in 10.7% and 
      13.9% of patients with RCC, respectively. We did not detect HHV-6A and BKV in any 
      of RCC tissue specimens. Moreover, no association was found between either of 
      these viruses and RCC. Our study revealed a significant association between 
      HHV-6B and p53 overexpression. No other associations were found between cellular 
      biomarkers p53, p16INK4a, Ki-67, and NF-kappaB and the studied viruses. The data of 
      this study, though very limited, disprove the involvement of HHV-6A, HHV-6B, BKV, 
      and JCV in the initiation or progression of RCC.
CI  - (c) 2022 The Societies and John Wiley & Sons Australia, Ltd.
FAU - Namdari, Sepide
AU  - Namdari S
AUID- ORCID: 0000-0003-1461-3054
AD  - Diagnostic Laboratory Sciences and Technology Research Center, School of 
      Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
FAU - Chong, Pei Pei
AU  - Chong PP
AUID- ORCID: 0000-0002-8229-3593
AD  - School of Biosciences, Faculty of Health and Medical Sciences, Taylor's 
      University, Subang Jaya, Malaysia.
FAU - Behzad-Behbahani, Abbas
AU  - Behzad-Behbahani A
AUID- ORCID: 0000-0001-5917-920X
AD  - Diagnostic Laboratory Sciences and Technology Research Center, School of 
      Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
FAU - Geramizadeh, Bita
AU  - Geramizadeh B
AUID- ORCID: 0000-0002-4867-5686
AD  - Department of Pathology, Medical School of Shiraz University, Shiraz University 
      of Medical Sciences, Shiraz, Iran.
AD  - Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
FAU - Nazhvani, Ali Dehghani
AU  - Nazhvani AD
AUID- ORCID: 0000-0002-9472-8793
AD  - Department of Oral and Maxillofacial Pathology, Biomaterials Research Center, 
      School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
FAU - Sekawi, Zamberi
AU  - Sekawi Z
AUID- ORCID: 0000-0002-5387-9640
AD  - Department of Medical Microbiology and Parasitology, Faculty of Medicine and 
      Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.
FAU - Farhadi, Ali
AU  - Farhadi A
AUID- ORCID: 0000-0002-2271-670X
AD  - Diagnostic Laboratory Sciences and Technology Research Center, School of 
      Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
LA  - eng
PT  - Journal Article
DEP - 20220926
PL  - Australia
TA  - Microbiol Immunol
JT  - Microbiology and immunology
JID - 7703966
RN  - 0 (DNA, Viral)
RN  - 0 (Ki-67 Antigen)
RN  - 0 (NF-kappa B)
RN  - 0 (Tumor Suppressor Protein p53)
SB  - IM
MH  - Humans
MH  - *Carcinoma, Renal Cell
MH  - DNA, Viral/genetics
MH  - *Herpesvirus 6, Human/genetics
MH  - *JC Virus/genetics
MH  - Ki-67 Antigen
MH  - *Kidney Neoplasms
MH  - NF-kappa B
MH  - Prospective Studies
MH  - Tumor Suppressor Protein p53/genetics
OTO - NOTNLM
OT  - HHV-6
OT  - Ki-67
OT  - NF-kappaB
OT  - p16INK4a
OT  - p53
OT  - polyomaviruses
OT  - renal cell carcinoma
EDAT- 2022/09/09 06:00
MHDA- 2022/11/15 06:00
CRDT- 2022/09/08 05:53
PHST- 2022/08/18 00:00 [revised]
PHST- 2022/06/25 00:00 [received]
PHST- 2022/09/03 00:00 [accepted]
PHST- 2022/09/09 06:00 [pubmed]
PHST- 2022/11/15 06:00 [medline]
PHST- 2022/09/08 05:53 [entrez]
AID - 10.1111/1348-0421.13026 [doi]
PST - ppublish
SO  - Microbiol Immunol. 2022 Nov;66(11):510-518. doi: 10.1111/1348-0421.13026. Epub 
      2022 Sep 26.