PMID- 36076481
OWN - NLM
STAT- MEDLINE
DCOM- 20221212
LR  - 20221212
IS  - 1950-6007 (Electronic)
IS  - 0753-3322 (Linking)
VI  - 153
DP  - 2022 Sep
TI  - Interval training and Crataegus persica ameliorate diabetic nephropathy via 
      miR-126/Nrf-2 mediated inhibition of stress oxidative in rats with diabetes after 
      myocardial ischemia-reperfusion injury.
PG  - 113411
LID - S0753-3322(22)00800-9 [pii]
LID - 10.1016/j.biopha.2022.113411 [doi]
AB  - Myocardial disorders are the most common cause of renal failure and mortality in 
      diabetic patients, but the molecular mechanism of this process is not yet clear. 
      The reduction of nuclear Erythroid2-related factor-2 (Nrf-2) and positive 
      regulators of Nrf-2 proteins, such as DJ-1 and microRNA-126 (miR-126), after 
      hypoxia and the promotion of reactive oxygen species, might be an intervention 
      indicator in renal failure after myocardial ischemia-reperfusion. Therefore, this 
      study evaluates the renoprotective effect of exercise training and Crataegus 
      persica extract (CE) on myocardial ischemia-reperfusion-induced kidney injury in 
      diabetic rats. Fifty rats were divided into five groups: healthy sedentary 
      control (Con), sedentary diabetic (D), interval trained diabetic (TD), diabetic 
      plus Crataegus persica extract treatment (CD), and interval trained diabetic plus 
      Crataegus persica extract treatment (TCD) groups. The rats in the exercise groups 
      were subjected to moderate-intensity interval training five days per week for ten 
      weeks. The rats in CD and TCD groups received 300 mg/kg of Crataegus persica 
      through gavage for ten weeks. Then, the subjects underwent 30 min of myocardial 
      ischemia and subsequently reperfusion for 24 h. At the end of the experiment, 
      insulin sensitivity, oxidative stress, renal function, histopathology of the 
      kidney, Nrf-2, miR-126, and DJ-1 gene expression levels were evaluated. The 
      results show that the treatments decreased elevated levels of renal oxidative 
      stress, glomerular filtration rate, insulin sensitivity, and pathological score 
      in diabetic rats. Also, the expression of Nrf-2 and miR-126, unlike DJ-1, 
      decreased in diabetic rats due to interval training. Due to the results, diabetes 
      aggravates acute myocardial ischemia-reperfusion-induced kidney injury, while 
      moderate-intensity interval training and Crataegus persica treatment 
      simultaneously ameliorate myocardial ischemia-reperfusion-induced renal injury 
      via miR-126/Nrf-2 pathway and improve insulin sensitivity and renal function in 
      type 1 diabetic rats.
CI  - Copyright (c) 2022 The Authors. Published by Elsevier Masson SAS.. All rights 
      reserved.
FAU - Asgari, Masoumeh
AU  - Asgari M
AD  - Department of Biology, North Tehran Branch, Islamic Azad University, Tehran, 
      Islamic Republic of Iran.
FAU - Salehi, Iraj
AU  - Salehi I
AD  - Department of Biology, North Tehran Branch, Islamic Azad University, Tehran, 
      Islamic Republic of Iran; Department of Physiology, School of Medicine, 
      Neurophysiology Research Center, Hamedan University of Medical Sciences, Hamedan, 
      Islamic Republic of Iran. Electronic address: irsalehi@yahoo.com.
FAU - Ranjbar, Kamal
AU  - Ranjbar K
AD  - Department of Physical Education and Sport Science, Bandar Abbas Branch, Islamic 
      Azad University, Bandar Abbas, Islamic Republic of Iran. Electronic address: 
      kamal_ranjbar2010@yahoo.com.
FAU - Khosravi, Maryam
AU  - Khosravi M
AD  - Department of Biology, North Tehran Branch, Islamic Azad University, Tehran, 
      Islamic Republic of Iran.
FAU - Zarrinkalam, Ebrahim
AU  - Zarrinkalam E
AD  - Department of Physical Education and Sport Science, Hamedan Branch, Islamic Azad 
      University, Hamedan, Islamic Republic of Iran.
LA  - eng
PT  - Journal Article
DEP - 20220719
PL  - France
TA  - Biomed Pharmacother
JT  - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
JID - 8213295
RN  - 0 (MicroRNAs)
RN  - 0 (MIRN126 microRNA, rat)
RN  - 0 (NF-E2-Related Factor 2)
RN  - 0 (Nfe2l2 protein, rat)
RN  - 0 (Plant Extracts)
SB  - IM
MH  - Animals
MH  - Rats
MH  - *Crataegus/chemistry
MH  - Diabetes Mellitus, Experimental/pathology
MH  - *Diabetic Nephropathies/therapy
MH  - Insulin Resistance
MH  - *MicroRNAs/genetics/metabolism
MH  - *Myocardial Reperfusion Injury/pathology/therapy
MH  - NF-E2-Related Factor 2
MH  - Oxidative Stress
MH  - Plant Extracts/adverse effects
MH  - Renal Insufficiency
MH  - *Physical Conditioning, Animal
OTO - NOTNLM
OT  - Diabetes
OT  - Exercise training
OT  - Kidney injury
OT  - Myocardial ischemia-reperfusion
OT  - l-arginine
COIS- Conflict of interest The authors declare that there are no conflicts of interest.
EDAT- 2022/09/10 06:00
MHDA- 2022/09/14 06:00
CRDT- 2022/09/09 01:01
PHST- 2022/04/30 00:00 [received]
PHST- 2022/07/05 00:00 [revised]
PHST- 2022/07/11 00:00 [accepted]
PHST- 2022/09/09 01:01 [entrez]
PHST- 2022/09/10 06:00 [pubmed]
PHST- 2022/09/14 06:00 [medline]
AID - S0753-3322(22)00800-9 [pii]
AID - 10.1016/j.biopha.2022.113411 [doi]
PST - ppublish
SO  - Biomed Pharmacother. 2022 Sep;153:113411. doi: 10.1016/j.biopha.2022.113411. Epub 
      2022 Jul 19.