PMID- 36077511
OWN - NLM
STAT- MEDLINE
DCOM- 20220912
LR  - 20220913
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 23
IP  - 17
DP  - 2022 Sep 4
TI  - The Role of Insulin Receptor Substrate Proteins in Bronchopulmonary Dysplasia and 
      Asthma: New Potential Perspectives.
LID - 10.3390/ijms231710113 [doi]
LID - 10113
AB  - Insulin receptor substrates (IRSs) are proteins that are involved in signaling 
      through the insulin receptor (IR) and insulin-like growth factor (IGFR). They can 
      also interact with other receptors including growth factor receptors. Thus, they 
      represent a critical node for the transduction and regulation of multiple 
      signaling pathways in response to extracellular stimuli. In addition, IRSs play a 
      central role in processes such as inflammation, growth, metabolism, and 
      proliferation. Previous studies have highlighted the role of IRS proteins in lung 
      diseases, in particular asthma. Further, the members of the IRS family are the 
      common proteins of the insulin growth factor signaling cascade involved in lung 
      development and disrupted in bronchopulmonary dysplasia (BPD). However, there is 
      no study focusing on the relationship between IRS proteins and BPD yet. 
      Unfortunately, there is still a significant gap in knowledge in this field. Thus, 
      in this review, we aimed to summarize the current knowledge with the major goal 
      of exploring the possible roles of IRS in BPD and asthma to foster new 
      perspectives for further investigations.
FAU - Gorgisen, Gokhan
AU  - Gorgisen G
AD  - Department of Medical Genetics, Faculty of Medicine, Van Yuzuncu Yil University, 
      Van 65080, Turkey.
FAU - Aydin, Malik
AU  - Aydin M
AD  - Laboratory of Experimental Pediatric Pneumology and Allergology, Center for 
      Biomedical Education and Research, School of Life Sciences (ZBAF), Faculty of 
      Health, Witten/Herdecke University, 58455 Witten, Germany.
AD  - Center for Child and Adolescent Medicine, Center for Clinical and Translational 
      Research (CCTR), Helios University Hospital Wuppertal, Witten/Herdecke 
      University, 42283 Wuppertal, Germany.
FAU - Mboma, Olivier
AU  - Mboma O
AD  - Laboratory of Experimental Pediatric Pneumology and Allergology, Center for 
      Biomedical Education and Research, School of Life Sciences (ZBAF), Faculty of 
      Health, Witten/Herdecke University, 58455 Witten, Germany.
AD  - Center for Child and Adolescent Medicine, Center for Clinical and Translational 
      Research (CCTR), Helios University Hospital Wuppertal, Witten/Herdecke 
      University, 42283 Wuppertal, Germany.
FAU - Gokyildirim, Mira Y
AU  - Gokyildirim MY
AD  - Department of Pediatrics, University Medical Center Rostock, University of 
      Rostock, 18057 Rostock, Germany.
FAU - Chao, Cho-Ming
AU  - Chao CM
AD  - Department of Pediatrics, University Medical Center Rostock, University of 
      Rostock, 18057 Rostock, Germany.
AD  - Cardio-Pulmonary Institute (CPI), Universities of Giessen and Marburg Lung Center 
      (UGMLC), Member of the German Center for Lung Research (DZL), Justus Liebig 
      University Giessen, 35390 Giessen, Germany.
LA  - eng
GR  - CH2361/2-1/Deutsche Forschungsgemeinschaft/
GR  - project numbers: IFF 2020-02/Witten/Herdecke University/
PT  - Journal Article
PT  - Review
DEP - 20220904
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Insulin)
RN  - 0 (Insulin Receptor Substrate Proteins)
RN  - 0 (Phosphoproteins)
RN  - EC 2.7.10.1 (Receptor, Insulin)
SB  - IM
MH  - *Asthma
MH  - *Bronchopulmonary Dysplasia
MH  - Humans
MH  - Infant, Newborn
MH  - Insulin/metabolism
MH  - Insulin Receptor Substrate Proteins/metabolism
MH  - Phosphoproteins/metabolism
MH  - Receptor, Insulin/metabolism
PMC - PMC9456457
OTO - NOTNLM
OT  - asthma
OT  - bronchopulmonary dysplasia
OT  - insulin receptor substrates
OT  - pediatric lung disease
COIS- The authors declare no conflict of interest. The funders had no role in the 
      design of the study; in the collection, analyses, or interpretation of data; in 
      the writing of the manuscript, or in the decision to publish the results.
EDAT- 2022/09/10 06:00
MHDA- 2022/09/14 06:00
PMCR- 2022/09/04
CRDT- 2022/09/09 01:09
PHST- 2022/08/14 00:00 [received]
PHST- 2022/08/30 00:00 [revised]
PHST- 2022/09/01 00:00 [accepted]
PHST- 2022/09/09 01:09 [entrez]
PHST- 2022/09/10 06:00 [pubmed]
PHST- 2022/09/14 06:00 [medline]
PHST- 2022/09/04 00:00 [pmc-release]
AID - ijms231710113 [pii]
AID - ijms-23-10113 [pii]
AID - 10.3390/ijms231710113 [doi]
PST - epublish
SO  - Int J Mol Sci. 2022 Sep 4;23(17):10113. doi: 10.3390/ijms231710113.