PMID- 36079162
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230308
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 11
IP  - 17
DP  - 2022 Sep 5
TI  - Factors Associated with Elevated Tumor Necrosis Factor-alpha in Aqueous Humor of 
      Patients with Open-Angle Glaucoma.
LID - 10.3390/jcm11175232 [doi]
LID - 5232
AB  - Tumor necrosis factor-alpha (TNF-alpha) is an important modulator of 
      neuroinflammation, secreted from activated glial cells in response to intraocular 
      stress. The purpose of this study was to investigate the clinical factors 
      associated with elevated TNF-alpha and its level in aqueous humor of patients with 
      open-angle glaucoma (OAG). Aqueous humor was collected from 73 OAG eyes, and 
      TNF-alpha level was analyzed using the singleplex bead immunoassay method. Patients 
      were divided into TNF-alpha-positive and TNF-alpha-negative groups according to the TNF-alpha 
      level of 10 pg/mL, and baseline clinical characteristics were compared. The 
      TNF-alpha-positive group showed higher baseline IOP, greater IOP fluctuation, and 
      higher systolic blood pressure than the TNF-alpha-negative group (p = 0.007, p < 
      0.001, and p = 0.009, respectively). In the multivariate logistic regression 
      analysis, IOP fluctuation (p = 0.037) and systolic blood pressure (p = 0.016) 
      were all independently associated with positive TNF-alpha level. In normal-tension 
      glaucoma (NTG) patients, presence of central scotoma (p = 0.029) was 
      significantly associated with positive TNF-alpha level. In conclusion, positive TNF-alpha 
      level in OAG patients was associated with greater IOP fluctuation and higher 
      systolic blood pressure. In NTG patients, positive TNF-alpha level was associated 
      with the presence of central scotoma. IOP factors and vascular factors, including 
      blood pressure and presence of central scotoma, may indicate glaucoma 
      pathogenesis related to TNF-alpha elevation in OAG patients.
FAU - Jung, Younhea
AU  - Jung Y
AD  - Department of Ophthalmology, Yeouido St. Mary's Hospital, College of Medicine, 
      The Catholic University of Korea, Seoul 07345, Korea.
FAU - Ohn, Kyoung
AU  - Ohn K
AD  - Department of Ophthalmology, Yeouido St. Mary's Hospital, College of Medicine, 
      The Catholic University of Korea, Seoul 07345, Korea.
FAU - Shin, Heejong
AU  - Shin H
AD  - Department of Ophthalmology, Seoul St. Mary's Hospital, College of Medicine, The 
      Catholic University of Korea, Seoul 06591, Korea.
FAU - Oh, Si Eun
AU  - Oh SE
AD  - Department of Ophthalmology, Seoul St. Mary's Hospital, College of Medicine, The 
      Catholic University of Korea, Seoul 06591, Korea.
FAU - Park, Chan Kee
AU  - Park CK
AD  - Department of Ophthalmology, Seoul St. Mary's Hospital, College of Medicine, The 
      Catholic University of Korea, Seoul 06591, Korea.
FAU - Park, Hae-Young Lopilly
AU  - Park HL
AUID- ORCID: 0000-0002-4536-5332
AD  - Department of Ophthalmology, Seoul St. Mary's Hospital, College of Medicine, The 
      Catholic University of Korea, Seoul 06591, Korea.
LA  - eng
GR  - 2021R1H1A2095534/National Research Foundation of Korea/
PT  - Journal Article
DEP - 20220905
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC9457301
OTO - NOTNLM
OT  - blood pressure
OT  - intraocular pressure
OT  - normal tension glaucoma
OT  - open angle glaucoma
OT  - tumor necrosis factor-alpha
OT  - vascular factor
COIS- The authors declare no conflict of interest.
EDAT- 2022/09/10 06:00
MHDA- 2022/09/10 06:01
PMCR- 2022/09/05
CRDT- 2022/09/09 01:20
PHST- 2022/07/28 00:00 [received]
PHST- 2022/08/31 00:00 [revised]
PHST- 2022/09/03 00:00 [accepted]
PHST- 2022/09/09 01:20 [entrez]
PHST- 2022/09/10 06:00 [pubmed]
PHST- 2022/09/10 06:01 [medline]
PHST- 2022/09/05 00:00 [pmc-release]
AID - jcm11175232 [pii]
AID - jcm-11-05232 [pii]
AID - 10.3390/jcm11175232 [doi]
PST - epublish
SO  - J Clin Med. 2022 Sep 5;11(17):5232. doi: 10.3390/jcm11175232.