PMID- 36081511
OWN - NLM
STAT- MEDLINE
DCOM- 20220913
LR  - 20221006
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 13
DP  - 2022
TI  - The impact of pulmonary tuberculosis on immunological and metabolic features of 
      diabetic patients.
PG  - 973991
LID - 10.3389/fimmu.2022.973991 [doi]
LID - 973991
AB  - Impaired immune responses have been observed in patients with type-2 diabetes 
      mellitus (T2DM), which increases susceptibility to tuberculosis infection. 
      However, the effect of the tuberculosis infection on the immunological and 
      metabolic features of T2DM is largely unknown. To investigate this question, age- 
      and sex-matched patients with pulmonary tuberculosis (PTB), T2DM, or T2DM 
      combined with PTB were recruited from the Infectious Disease Hospital of 
      Heilongjiang Province between January and September 2020. Healthy subjects were 
      used as controls. Cytokines and chemokines in fasting serum samples were 
      determined using the Quantibody Inflammation Array. Compared with T2DM alone, 
      patients with T2DM combined with PTB have higher fasting blood glucose levels and 
      monocyte counts in circulation. Among the four groups, circulating IL-10 levels 
      peaked in patients with T2DM and PTB (p<0.05). Univariate linear analysis showed 
      that serum IL-10 levels were positively associated with myeloid cells but 
      negatively correlated with lymphocyte counts in these patients (p<0.05). Serum 
      IL-6 levels were 1.6-fold higher in patients with T2DM plus PTB than in those 
      with T2DM alone. In conclusion, PTB infection in patients with T2DM had distinct 
      inflammatory profiles and sustained hyperglycaemia compared with PTB or T2DM 
      alone. IL-10 levels and elevated monocyte counts could be hallmarks of patients 
      with T2DM infected with PTB.
CI  - Copyright (c) 2022 Chen, Su, Bao, Zhang, Li and Mao.
FAU - Chen, Haijun
AU  - Chen H
AD  - Department of Computed Tomography, Heilongjiang Provincial Hospital, Harbin, 
      China.
FAU - Su, Li
AU  - Su L
AD  - Neuroscience Research Institute, Peking University Center of Medical and Health 
      Analysis, Peking University, Beijing, China.
FAU - Bao, Jinhua
AU  - Bao J
AD  - College of Sports and Human Sciences, Harbin Sport University, Harbin, China.
FAU - Zhang, Kun
AU  - Zhang K
AD  - Department of Clinical Nutrition, Heilongjiang Provincial Hospital, Harbin, 
      China.
FAU - Li, Yuze
AU  - Li Y
AD  - Department of Clinical Nutrition, Heilongjiang Provincial Hospital, Harbin, 
      China.
AD  - Department of the Fourth Internal Medicine, The Fourth Hospital of Heilongjiang 
      Province, Harbin, China.
FAU - Mao, Enuo
AU  - Mao E
AD  - Department of Discipline Inspection and Supervision, Heilongjiang Provincial 
      Hospital, Harbin, China.
LA  - eng
PT  - Journal Article
DEP - 20220823
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - *Diabetes Mellitus, Type 2/immunology/metabolism
MH  - Humans
MH  - Interleukin-10
MH  - Latent Tuberculosis
MH  - Tuberculosis
MH  - *Tuberculosis, Pulmonary/complications
PMC - PMC9446150
OTO - NOTNLM
OT  - cytokines
OT  - interleukin 10
OT  - monocytes
OT  - pulmonary tuberculosis
OT  - type-2 diabetes mellitus
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/09/10 06:00
MHDA- 2022/09/14 06:00
PMCR- 2022/01/01
CRDT- 2022/09/09 02:06
PHST- 2022/06/20 00:00 [received]
PHST- 2022/07/27 00:00 [accepted]
PHST- 2022/09/09 02:06 [entrez]
PHST- 2022/09/10 06:00 [pubmed]
PHST- 2022/09/14 06:00 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2022.973991 [doi]
PST - epublish
SO  - Front Immunol. 2022 Aug 23;13:973991. doi: 10.3389/fimmu.2022.973991. eCollection 
      2022.