PMID- 36082131
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220912
IS  - 2297-055X (Print)
IS  - 2297-055X (Electronic)
IS  - 2297-055X (Linking)
VI  - 9
DP  - 2022
TI  - Cardiac resynchronization therapy in heart failure patients by using left bundle 
      branch pacing.
PG  - 990016
LID - 10.3389/fcvm.2022.990016 [doi]
LID - 990016
AB  - BACKGROUND: Left bundle branch pacing (LBBP) is emerging as an effective 
      alternative to achieve cardiac resynchronization therapy (CRT) and improve heart 
      function. The purpose of our study was to investigate the feasibility and 
      efficacy of LBBP in heart failure patients with left ventricular ejection 
      fraction (LVEF) <50% and left bundle branch block (LBBB). METHODS: All patients 
      with complete LBBB and LVEF <50% were retrospectively included in the study from 
      April 2018 to April 2021 and underwent CRT via LBBP implantation. ECG, pacing 
      parameters, the New York Heart Association (NYHA) functional class, 
      echocardiographic measurements, and complications were recorded and analyzed at 
      implant and during follow-up of 1, 6, and 12 months. RESULTS: Left bundle branch 
      pacing was successful in all 34 patients (mean age 65.6 +/- 11.2 years, 67.6% men). 
      A significant decrease in QRS duration (QRSd) was observed after the LBBP 
      operation for 1 month (153.2 +/- 1.7 vs. 111.9 +/- 2.6 ms, p < 0.01). LBB capture 
      threshold and R-wave amplitude remained stable at 12-month follow-up when 
      compared with implantation values (0.62 +/- 0.13 V @ 0.4 ms vs. 0.73 +/- 0.21 V @ 0.4 
      ms, 12.02 +/- 5.68 mV vs. 8.58 +/- 4.09 mV, respectively). LVEF increased 
      significantly (35.28 +/- 1.70% vs. 51.09 +/- 1.71%, p < 0.01) accompanied with 
      reduced left ventricular end-diastolic dimension (LVEDd; 65.3 +/- 1.99 vs. 53.58 +/- 
      2.07 mm, p < 0.01) and left atrial dimension (LAD; 49.03 +/- 1.32 vs. 40.67 +/- 1.58 
      mm, p < 0.01). Normalized LVEF (LVEF >/= 50%) was found in 70.5% of patients at 12 
      months. The NYHA classification, brain natriuretic peptide (BNP), and 6-minute 
      walk test (6MWT) were significantly improved at follow-up of 12 months (all p < 
      0.01 vs. baseline). No deaths or heart failure hospitalizations were observed 
      during the follow-up period. CONCLUSION: The current work suggested that LBBP was 
      feasible with a high success implantation rate and effective to correct LBBB and 
      improved left ventricular structure and function with a low and stable pacing 
      threshold.
CI  - Copyright (c) 2022 Gu, Li, Zhu, Lin, Tian, Zhang, Gong, Wang and Li.
FAU - Gu, Ying
AU  - Gu Y
AD  - Department of Cardiology, Jinling Hospital, Nanjing University School of 
      Medicine, Nanjing, China.
FAU - Li, Yanming
AU  - Li Y
AD  - Department of Cardiology, Jinling Hospital, Nanjing University School of 
      Medicine, Nanjing, China.
FAU - Zhu, Ying
AU  - Zhu Y
AD  - Department of Cardiology, Jinling Hospital, Nanjing University School of 
      Medicine, Nanjing, China.
FAU - Lin, Xiuyu
AU  - Lin X
AD  - Department of Ultrasonic Diagnosis, Jinling Hospital, Nanjing University School 
      of Medicine, Nanjing, China.
FAU - Tian, Tian
AU  - Tian T
AD  - Department of Ultrasonic Diagnosis, Jinling Hospital, Nanjing University School 
      of Medicine, Nanjing, China.
FAU - Zhang, Qigao
AU  - Zhang Q
AD  - Department of Cardiology, Jinling Hospital, Nanjing University School of 
      Medicine, Nanjing, China.
FAU - Gong, Jianbin
AU  - Gong J
AD  - Department of Cardiology, Jinling Hospital, Nanjing University School of 
      Medicine, Nanjing, China.
FAU - Wang, Lei
AU  - Wang L
AD  - Department of Cardiology, Jinling Hospital, Nanjing University School of 
      Medicine, Nanjing, China.
FAU - Li, Jianhua
AU  - Li J
AD  - Department of Cardiology, Jinling Hospital, Nanjing University School of 
      Medicine, Nanjing, China.
LA  - eng
PT  - Journal Article
DEP - 20220823
PL  - Switzerland
TA  - Front Cardiovasc Med
JT  - Frontiers in cardiovascular medicine
JID - 101653388
PMC - PMC9445246
OTO - NOTNLM
OT  - cardiac resynchronization therapy
OT  - heart failure
OT  - left bundle branch block
OT  - left bundle branch pacing
OT  - pacing threshold
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/09/10 06:00
MHDA- 2022/09/10 06:01
PMCR- 2022/01/01
CRDT- 2022/09/09 02:20
PHST- 2022/07/09 00:00 [received]
PHST- 2022/08/02 00:00 [accepted]
PHST- 2022/09/09 02:20 [entrez]
PHST- 2022/09/10 06:00 [pubmed]
PHST- 2022/09/10 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fcvm.2022.990016 [doi]
PST - epublish
SO  - Front Cardiovasc Med. 2022 Aug 23;9:990016. doi: 10.3389/fcvm.2022.990016. 
      eCollection 2022.