PMID- 36082795
OWN - NLM
STAT- MEDLINE
DCOM- 20230208
LR  - 20230317
IS  - 1897-4279 (Electronic)
IS  - 0022-9032 (Linking)
VI  - 81
IP  - 1
DP  - 2023
TI  - Clinical factors affecting survival in patients with D-transposition of the great 
      arteries after atrial switch repair: A meta-analysis.
PG  - 38-47
LID - 10.33963/KP.a2022.0209 [doi]
AB  - BACKGROUND: Atrial switch repair (AtrSR) was the initial operation method in 
      patients with D-transposition of the great arteries (D-TGA) constituting the 
      right ventricle as a systemic one. Currently, it has been replaced with arterial 
      switch operation (ASO), but the cohort of adults after AtrSR is still large and 
      requires strict cardiological management of late complications. For this reason, 
      we aimed to evaluate potential long-term mortality risk factors in patients with 
      D-TGA after AtrSR (either Mustard or Senning procedures) Methods: We searched the 
      MEDLINE database for suitable trials. We included 22 retrospective and 
      prospective cohort studies of patients with D-TGA with at least 5 years 
      mean/median follow-up time after Mustard or Senning procedures, with an endpoint 
      of non-sudden cardiac death (n-SCD) and sudden cardiac death (SCD) after at least 
      30 days following surgery. RESULTS: A total of 2912 patients were enrolled, of 
      whom 351 met the combined endpoint of n-SCD/SCD. The long-term mortality risk 
      factors were New York Heart Association (NYHA) class >/=III/heart failure 
      hospitalization (odds ratio [OR], 7.25; 95% confidence interval [CI], 2.67-19.7), 
      tricuspid valve regurgitation (OR, 4.64; 95% CI, 1.95-11.05), Mustard procedure 
      (OR, 2.15; 95% CI, 1.37-3.35), complex D-TGA (OR, 2.41; 95% CI, 1.31-4.43), and 
      right ventricular dysfunction (OR, 1.94; 95% CI, 0.99-3.79). Supraventricular 
      arrhythmia (SVT; OR, 2.07; 95% CI, 0.88-4.85) and pacemaker implantation (OR, 
      2.37; 95% CI, 0.48-11.69) did not affect long-term survival in this group of 
      patients. In an additional analysis, SVT showed a statistically significant 
      impact on SCD (OR, 2.74; 95% CI, 1.36-5.53) but not on n-SCD (OR, 1.5; 95% CI, 
      0.37-6.0). CONCLUSIONS: This meta-analysis demonstrated that at least moderate 
      tricuspid valve regurgitation, NYHA class >/=III/heart failure hospitalization, 
      right ventricular dysfunction, complex D-TGA, and Mustard procedure are risk 
      factors for long-term mortality in patients after AtrSR.
FAU - Nartowicz, Sonia Alicja
AU  - Nartowicz SA
AD  - Poznan University of Medical Sciences, Poznan, Poland. sonianartowicz@ymail.com.
FAU - Jakielska, Ewelina
AU  - Jakielska E
AD  - Poznan University of Medical Sciences, Poznan, Poland.
FAU - Cieplucha, Aleksandra
AU  - Cieplucha A
AD  - 1st Department of Cardiology, Poznan University of Medical Sciences, Poznan, 
      Poland.
FAU - Ratajczak, Piotr
AU  - Ratajczak P
AD  - Department of Pharmacoeconomics and Social Pharmacy, Poznan University of Medical 
      Sciences, Poznan, Poland.
FAU - Grajek, Stefan
AU  - Grajek S
AD  - Poznan University of Medical Sciences, Poznan, Poland.
FAU - Lesiak, Maciej
AU  - Lesiak M
AD  - Poznan University of Medical Sciences, Poznan, Poland.
FAU - Trojnarska, Olga
AU  - Trojnarska O
AD  - Poznan University of Medical Sciences, Poznan, Poland.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20220909
PL  - Poland
TA  - Kardiol Pol
JT  - Kardiologia polska
JID - 0376352
SB  - IM
MH  - Adult
MH  - Humans
MH  - *Arterial Switch Operation/adverse effects
MH  - *Transposition of Great Vessels/surgery/complications
MH  - *Tricuspid Valve Insufficiency
MH  - Retrospective Studies
MH  - *Ventricular Dysfunction, Right/surgery/complications
MH  - Prospective Studies
MH  - *Heart Failure/etiology
MH  - Death, Sudden, Cardiac/etiology
MH  - Arteries
MH  - Follow-Up Studies
MH  - Treatment Outcome
OTO - NOTNLM
OT  - D-transposition of the great arteries
OT  - atrial switch repair
OT  - mustard procedure
OT  - senning procedure
EDAT- 2022/09/10 06:00
MHDA- 2023/02/09 06:00
CRDT- 2022/09/09 06:32
PHST- 2022/09/02 00:00 [received]
PHST- 2022/09/02 00:00 [accepted]
PHST- 2022/09/10 06:00 [pubmed]
PHST- 2023/02/09 06:00 [medline]
PHST- 2022/09/09 06:32 [entrez]
AID - VM/OJS/J/91706 [pii]
AID - 10.33963/KP.a2022.0209 [doi]
PST - ppublish
SO  - Kardiol Pol. 2023;81(1):38-47. doi: 10.33963/KP.a2022.0209. Epub 2022 Sep 9.