PMID- 36082926
OWN - NLM
STAT- MEDLINE
DCOM- 20230419
LR  - 20230419
IS  - 1784-973X (Electronic)
IS  - 0001-5385 (Linking)
VI  - 78
IP  - 2
DP  - 2023 Apr
TI  - Association between DLCO index and the severity of heart failure: a 
      cross-sectional study.
PG  - 250-255
LID - 10.1080/00015385.2022.2066776 [doi]
AB  - BACKGROUND: The prognostic role of diffusing capacity of the lung for carbon 
      monoxide (DLCO) in heart failure has not been thoroughly investigated. Therefore, 
      this study aimed to evaluate DLCO variation in different systolic and diastolic 
      heart failure stages. METHODS: This was a prospective cross-sectional study on 51 
      patients with systolic (reduced LVEF) or diastolic (preserved LVEF) chronic heart 
      failure (CHF). All patients underwent a standard DLCO test. The associations 
      between the severity of heart failure and reduced carbon monoxide transfer factor 
      (TLCO), carbon monoxide transfer coefficient (KCO), and alveolar volume (VA) were 
      investigated. Data were analysed using SPSS software version 16. p-Values below 
      0.05 were considered statistically significant. RESULTS: The mean age of 
      participants was 59.29 +/- 14.91 years, with 72% of the study population being 
      male. Systolic heart failure was observed in 47% of patients, diastolic heart 
      failure in 18%, and a mixed systolic and diastolic pattern in 35%. There were 
      significant differences between TLCO percentage in patients with CHF types and 
      the New York Heart Association (NYHA) functional classes (p = 0.042). Overall, an 
      ejection fraction (EF) of less than 25% correlated with 3%, 53%, and 0.78 
      declines in TLCO, KCO%, and KCO index, respectively. CONCLUSION: Despite the lack 
      of statistically significant differences between DLCO indices and CHF severity, 
      decreased DLCO parameters correlated with reduced EF. Therefore, DLCO testing 
      might be helpful to predict HF severity.
FAU - Izadi, Shirin
AU  - Izadi S
AD  - Assistant Professor of Pulmonary Disease, Department of Internal Medicine, School 
      of Medicine, Firoozgar General Hospital, Iran University of Medical Sciences.
FAU - Esmaili, Saeedeh
AU  - Esmaili S
AD  - Residence of Internal Medicine, Firoozgar Medical & Educational Hospital, 
      Department of Internal Medicine, School of Medicine, Iran University of Medical 
      Sciences, Tehran, Iran.
FAU - Emami, Sepideh
AU  - Emami S
AD  - Assistant Professor of cardiology, Department of cardiology, School of Medicine, 
      Firoozgar General Hospital, Iran University of Medical Sciences.
FAU - Izadi, Shahrokh
AU  - Izadi S
AD  - School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran.
FAU - Eskandari, Mohana
AU  - Eskandari M
AD  - Residence of Internal Medicine, Firoozgar Medical & Educational Hospital, 
      Department of Internal Medicine, School of Medicine, Iran University of Medical 
      Sciences, Tehran, Iran.
FAU - Yadollahzadeh, Mahdi
AU  - Yadollahzadeh M
AUID- ORCID: 0000-0001-5304-6705
AD  - Assistant Professor of Pulmonary Disease, Department of Internal Medicine, School 
      of Medicine, Firoozgar General Hospital, Iran University of Medical Sciences.
FAU - Saleh, Maasoumeh
AU  - Saleh M
AD  - Department of Obstetrics and Gynecology, Tehran University of Medical Sciences, 
      Shariati hospital, Tehran, Iran.
FAU - Khavandegar, Armin
AU  - Khavandegar A
AUID- ORCID: 0000-0002-4761-8938
AD  - Student Research Committee, Alborz University of Medical Sciences, Karaj, Iran.
FAU - Bakhtiyari, Mahmood
AU  - Bakhtiyari M
AUID- ORCID: 0000-0002-1216-7671
AD  - Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, 
      Karaj, Iran.
LA  - eng
PT  - Journal Article
DEP - 20220909
PL  - England
TA  - Acta Cardiol
JT  - Acta cardiologica
JID - 0370570
RN  - 7U1EE4V452 (Carbon Monoxide)
SB  - IM
MH  - Humans
MH  - Male
MH  - Adult
MH  - Middle Aged
MH  - Aged
MH  - Female
MH  - Cross-Sectional Studies
MH  - *Pulmonary Diffusing Capacity
MH  - Carbon Monoxide
MH  - Prospective Studies
MH  - *Heart Failure/diagnosis
OTO - NOTNLM
OT  - Heart failure
OT  - diastolic CHF
OT  - diffusing capacity of the lung for carbon monoxide
OT  - systolic CHF
EDAT- 2022/09/10 06:00
MHDA- 2023/04/19 06:41
CRDT- 2022/09/09 07:33
PHST- 2023/04/19 06:41 [medline]
PHST- 2022/09/10 06:00 [pubmed]
PHST- 2022/09/09 07:33 [entrez]
AID - 10.1080/00015385.2022.2066776 [doi]
PST - ppublish
SO  - Acta Cardiol. 2023 Apr;78(2):250-255. doi: 10.1080/00015385.2022.2066776. Epub 
      2022 Sep 9.