PMID- 36083983
OWN - NLM
STAT- MEDLINE
DCOM- 20220913
LR  - 20220926
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 17
IP  - 9
DP  - 2022
TI  - Outdoor residual spraying for malaria vector-control in Kayin (Karen) state, 
      Myanmar: A cluster randomized controlled trial.
PG  - e0274320
LID - 10.1371/journal.pone.0274320 [doi]
LID - e0274320
AB  - Outdoor and early biting by mosquitoes challenge the efficacy of bed nets and 
      indoor residual spraying against malaria in the Greater Mekong Subregion. The 
      objective of this study was to assess the efficacy of outdoor residual spraying 
      (ORS) for malaria vector-control in this region. A cluster randomized controlled 
      trial was conducted between July 2018 and April 2019 in twelve villages in Karen 
      (Kayin) state, Myanmar. Villages were randomly assigned to receive either a 
      single round of ORS with a capsule suspension of lambda-cyhalothrin for two days 
      in October or no intervention (six villages per group). The primary endpoint was 
      the biting rate of malaria mosquitoes assessed with human-landing catch and 
      cow-baited trap collection methods, and was analyzed with a Bayesian multi-level 
      model. In the intervention villages, the proportion of households located within 
      the sprayed area ranged between 42 and 100% and the application rate ranged 
      between 63 and 559 g of active ingredient per hectare. At baseline, the median of 
      Anopheles biting rate estimates in the twelve villages was 2 bites per person per 
      night (inter-quartile range [IQR] 0-5, range 0-48) indoors, 6 bites per person 
      per night (IQR 2-16, range 0-342) outdoors and 206 bites per cow per night (IQR 
      83-380, range 19-1149) in the cow-baited trap. In intention-to-treat analysis, it 
      was estimated that ORS reduced biting rate by 72% (95% confidence interval [CI] 
      63-79) from Month 0 to Month 3 and by 79% (95% CI 62-88) from Month 4 to Month 6, 
      considering control villages as the reference. In conclusion, ORS rapidly reduces 
      the biting rates of malaria mosquitoes in a Southeast Asian setting where the 
      vectors bite mostly outdoors and at a time when people are not protected by 
      mosquito bed nets.
FAU - Chaumeau, Victor
AU  - Chaumeau V
AUID- ORCID: 0000-0003-0171-2176
AD  - Shoklo Malaria Research Unit, Mahidol-Oxford Research Unit, Faculty of Tropical 
      Medicine, Mahidol University, Mae Sot, Thailand.
AD  - Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, 
      University of Oxford, Oxford, United Kingdom.
FAU - Kajeechiwa, Ladda
AU  - Kajeechiwa L
AD  - Shoklo Malaria Research Unit, Mahidol-Oxford Research Unit, Faculty of Tropical 
      Medicine, Mahidol University, Mae Sot, Thailand.
FAU - Kulabkeeree, Thithiworada
AU  - Kulabkeeree T
AD  - Shoklo Malaria Research Unit, Mahidol-Oxford Research Unit, Faculty of Tropical 
      Medicine, Mahidol University, Mae Sot, Thailand.
FAU - Sawasdichai, Sunisa
AU  - Sawasdichai S
AD  - Shoklo Malaria Research Unit, Mahidol-Oxford Research Unit, Faculty of Tropical 
      Medicine, Mahidol University, Mae Sot, Thailand.
FAU - Haohankhunnatham, Warat
AU  - Haohankhunnatham W
AD  - Shoklo Malaria Research Unit, Mahidol-Oxford Research Unit, Faculty of Tropical 
      Medicine, Mahidol University, Mae Sot, Thailand.
FAU - Inta, Aritsara
AU  - Inta A
AD  - Shoklo Malaria Research Unit, Mahidol-Oxford Research Unit, Faculty of Tropical 
      Medicine, Mahidol University, Mae Sot, Thailand.
FAU - Phanaphadungtham, Monthicha
AU  - Phanaphadungtham M
AD  - Shoklo Malaria Research Unit, Mahidol-Oxford Research Unit, Faculty of Tropical 
      Medicine, Mahidol University, Mae Sot, Thailand.
FAU - Girond, Florian
AU  - Girond F
AD  - Institut Pasteur du Cambodge, Institut Pasteur International Network, Phnom Penh, 
      Cambodia.
AD  - Institut de Recherche pour le Developpement, UMR 228 Espace-Dev (IRD, UA, UG, UM, 
      UR), Phnom Penh, Cambodia.
FAU - Herbreteau, Vincent
AU  - Herbreteau V
AUID- ORCID: 0000-0003-1762-6336
AD  - Institut de Recherche pour le Developpement, UMR 228 Espace-Dev (IRD, UA, UG, UM, 
      UR), Phnom Penh, Cambodia.
FAU - Delmas, Gilles
AU  - Delmas G
AD  - Shoklo Malaria Research Unit, Mahidol-Oxford Research Unit, Faculty of Tropical 
      Medicine, Mahidol University, Mae Sot, Thailand.
AD  - Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, 
      University of Oxford, Oxford, United Kingdom.
FAU - Nosten, Francois
AU  - Nosten F
AUID- ORCID: 0000-0002-7951-0745
AD  - Shoklo Malaria Research Unit, Mahidol-Oxford Research Unit, Faculty of Tropical 
      Medicine, Mahidol University, Mae Sot, Thailand.
AD  - Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, 
      University of Oxford, Oxford, United Kingdom.
LA  - eng
GR  - 220211/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20220909
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Animals
MH  - *Anopheles
MH  - Bayes Theorem
MH  - Cattle
MH  - Feeding Behavior
MH  - Female
MH  - Humans
MH  - *Malaria/epidemiology/prevention & control
MH  - Mosquito Control/methods
MH  - Mosquito Vectors
MH  - Myanmar/epidemiology
PMC - PMC9462579
COIS- The authors have declared that no competing interests exist.
EDAT- 2022/09/10 06:00
MHDA- 2022/09/14 06:00
PMCR- 2022/09/09
CRDT- 2022/09/09 14:05
PHST- 2022/04/25 00:00 [received]
PHST- 2022/08/26 00:00 [accepted]
PHST- 2022/09/09 14:05 [entrez]
PHST- 2022/09/10 06:00 [pubmed]
PHST- 2022/09/14 06:00 [medline]
PHST- 2022/09/09 00:00 [pmc-release]
AID - PONE-D-22-11850 [pii]
AID - 10.1371/journal.pone.0274320 [doi]
PST - epublish
SO  - PLoS One. 2022 Sep 9;17(9):e0274320. doi: 10.1371/journal.pone.0274320. 
      eCollection 2022.