PMID- 36085159
OWN - NLM
STAT- MEDLINE
DCOM- 20220913
LR  - 20220928
IS  - 1476-069X (Electronic)
IS  - 1476-069X (Linking)
VI  - 21
IP  - 1
DP  - 2022 Sep 9
TI  - Perfluoroalkyl substances (PFASs) as risk factors for breast cancer: a 
      case-control study in Chinese population.
PG  - 83
LID - 10.1186/s12940-022-00895-3 [doi]
LID - 83
AB  - BACKGROUND: Perfluoroalkyl substances (PFASs) are a large family of synthetic 
      chemicals, some of which are mammary toxicants and endocrine disruptors. Recent 
      studies have implicated exposure to PFASs as a risk factor for breast cancer in 
      Europe and America. Little is known about the role of PFASs with respect to 
      breast cancer in the Chinese population. METHODS: Participants who were initially 
      diagnosed with breast cancer at Tianjin Medical University Cancer Institute and 
      Hospital between 2012 and 2016 were recruited as cases. The controls were 
      randomly selected from the participants with available blood samples in the 
      Chinese National Breast Cancer Screening Program (CNBCSP) cohort. Ultimately, we 
      enrolled 373 breast cancer patients and 657 controls. Plasma PFASs were measured 
      by an ultra-performance liquid chromatography (UPLC) system coupled to a 5500 
      Q-Trap triple quadrupole mass spectrometer. A logistic regression model with 
      least absolute shrinkage and selection operator (LASSO) regularization was used 
      to calculate odds ratios (ORs) and 95% confidence intervals (CIs) to assess the 
      relationships between PFASs and breast cancer. The three most predictive 
      variables in the LASSO model were selected from 17 PFASs, which was based on the 
      optimal penalty coefficient (lambda = 0.0218) identified with the minimum criterion. 
      Additionally, Bayesian kernel machine regression (BKMR) and quantile 
      g-computation models were applied to evaluate the associations between separate 
      and mixed exposure to PFASs and breast cancer. RESULTS: Perfluorooctanesulfonic 
      acid (PFOS) exhibited the highest concentration in both the cases and controls. 
      Perfluorooctanoic acid (PFOA) and perfluoro-n-decanoic acid (PFDA) were 
      positively associated with breast cancer, and perfluoro-n-tridecanoic acid 
      (PFTrDA) was negatively associated with breast cancer according to both the 
      continuous-PFASs and the quartile-PFASs logistic regression models. Of note, PFOA 
      was associated with the occurrence of estrogen receptor (ER)-, progesterone 
      receptor (PR)-, and human epidermal growth factor receptor 2 (HER2)-positive 
      breast cancer (OR(ER+)  = 1.47, 95% CI: 1.19, 1.80; OR(PR+)  = 1.36, 95% CI: 
      1.09, 1.69; OR(HER2) = 1.62, 95% CI: 1.19, 2.21). CONCLUSIONS: Overall, we 
      observed that PFASs were associated with breast cancer in Chinese women. 
      Prospective cohort studies and mechanistic experiments are warranted to elucidate 
      whether these associations are causal.
CI  - (c) 2022. The Author(s).
FAU - Li, Xuejun
AU  - Li X
AD  - Department of Occupational and Environmental Health, School of Public Health, 
      Center for International Collaborative Research on Environment, Nutrition, and 
      Public Health, Tianjin Key Laboratory of Environment, Nutrition, and Public 
      Health, Tianjin Medical University, No.22 Qixiangtai Road, Heping District, 
      Tianjin, 300070, China.
FAU - Song, Fengju
AU  - Song F
AD  - Department of Epidemiology and Biostatistics, Key Laboratory of Breast Cancer 
      Prevention and Therapy in Ministry of Education, Key Laboratory of Molecular 
      Cancer Epidemiology of Tianjin, National Clinical Research Center for Cancer, 
      Tianjin Medical University Cancer Institute and Hospital, Tianjin, 300060, China.
FAU - Liu, Xiaotu
AU  - Liu X
AD  - School of Environment, Guangzhou Key Laboratory of Environmental Exposure and 
      Health, and Guangdong Key Laboratory of Environmental Pollution and Health, Jinan 
      University, Guangzhou, 510632, China.
FAU - Shan, Anqi
AU  - Shan A
AD  - Department of Occupational and Environmental Health, School of Public Health, 
      Center for International Collaborative Research on Environment, Nutrition, and 
      Public Health, Tianjin Key Laboratory of Environment, Nutrition, and Public 
      Health, Tianjin Medical University, No.22 Qixiangtai Road, Heping District, 
      Tianjin, 300070, China.
FAU - Huang, Yubei
AU  - Huang Y
AD  - Department of Epidemiology and Biostatistics, Key Laboratory of Breast Cancer 
      Prevention and Therapy in Ministry of Education, Key Laboratory of Molecular 
      Cancer Epidemiology of Tianjin, National Clinical Research Center for Cancer, 
      Tianjin Medical University Cancer Institute and Hospital, Tianjin, 300060, China.
FAU - Yang, Zhengjun
AU  - Yang Z
AD  - The First Department of Breast Cancer, Tianjin Medical University Cancer 
      Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, 
      300060, China.
FAU - Li, Haixin
AU  - Li H
AD  - Department of Epidemiology and Biostatistics, Key Laboratory of Breast Cancer 
      Prevention and Therapy in Ministry of Education, Key Laboratory of Molecular 
      Cancer Epidemiology of Tianjin, National Clinical Research Center for Cancer, 
      Tianjin Medical University Cancer Institute and Hospital, Tianjin, 300060, China.
FAU - Yang, Qiaoyun
AU  - Yang Q
AD  - Department of Occupational and Environmental Health, School of Public Health, 
      Center for International Collaborative Research on Environment, Nutrition, and 
      Public Health, Tianjin Key Laboratory of Environment, Nutrition, and Public 
      Health, Tianjin Medical University, No.22 Qixiangtai Road, Heping District, 
      Tianjin, 300070, China.
FAU - Yu, Yue
AU  - Yu Y
AD  - The First Department of Breast Cancer, Tianjin Medical University Cancer 
      Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, 
      300060, China.
FAU - Zheng, Hong
AU  - Zheng H
AD  - Department of Epidemiology and Biostatistics, Key Laboratory of Breast Cancer 
      Prevention and Therapy in Ministry of Education, Key Laboratory of Molecular 
      Cancer Epidemiology of Tianjin, National Clinical Research Center for Cancer, 
      Tianjin Medical University Cancer Institute and Hospital, Tianjin, 300060, China.
FAU - Cao, Xu-Chen
AU  - Cao XC
AD  - The First Department of Breast Cancer, Tianjin Medical University Cancer 
      Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, 
      300060, China.
FAU - Chen, Da
AU  - Chen D
AD  - School of Environment, Guangzhou Key Laboratory of Environmental Exposure and 
      Health, and Guangdong Key Laboratory of Environmental Pollution and Health, Jinan 
      University, Guangzhou, 510632, China.
FAU - Chen, Ke-Xin
AU  - Chen KX
AD  - Department of Epidemiology and Biostatistics, Key Laboratory of Breast Cancer 
      Prevention and Therapy in Ministry of Education, Key Laboratory of Molecular 
      Cancer Epidemiology of Tianjin, National Clinical Research Center for Cancer, 
      Tianjin Medical University Cancer Institute and Hospital, Tianjin, 300060, China.
FAU - Chen, Xi
AU  - Chen X
AUID- ORCID: 0000-0002-1185-9828
AD  - Department of Occupational and Environmental Health, School of Public Health, 
      Center for International Collaborative Research on Environment, Nutrition, and 
      Public Health, Tianjin Key Laboratory of Environment, Nutrition, and Public 
      Health, Tianjin Medical University, No.22 Qixiangtai Road, Heping District, 
      Tianjin, 300070, China. chenxi@tmu.edu.cn.
FAU - Tang, Nai-Jun
AU  - Tang NJ
AUID- ORCID: 0000-0002-1177-252X
AD  - Department of Occupational and Environmental Health, School of Public Health, 
      Center for International Collaborative Research on Environment, Nutrition, and 
      Public Health, Tianjin Key Laboratory of Environment, Nutrition, and Public 
      Health, Tianjin Medical University, No.22 Qixiangtai Road, Heping District, 
      Tianjin, 300070, China. tangnaijun@tmu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220909
PL  - England
TA  - Environ Health
JT  - Environmental health : a global access science source
JID - 101147645
RN  - 0 (Fluorocarbons)
SB  - IM
MH  - Bayes Theorem
MH  - *Breast Neoplasms/chemically induced/epidemiology
MH  - Case-Control Studies
MH  - China/epidemiology
MH  - Female
MH  - *Fluorocarbons
MH  - Humans
MH  - Prospective Studies
MH  - Risk Factors
PMC - PMC9463854
OTO - NOTNLM
OT  - Bayesian kernel machine regression (BKMR)
OT  - Breast cancer
OT  - Case-control study
OT  - Chinese population
OT  - Least absolute shrinkage and selection operator (LASSO)
OT  - Perfluoroalkyl substances (PFASs)
OT  - Quantile g-computation approach
COIS- The authors declare that they have no competing interests.
EDAT- 2022/09/10 06:00
MHDA- 2022/09/14 06:00
PMCR- 2022/09/09
CRDT- 2022/09/09 23:44
PHST- 2022/05/07 00:00 [received]
PHST- 2022/08/27 00:00 [accepted]
PHST- 2022/09/09 23:44 [entrez]
PHST- 2022/09/10 06:00 [pubmed]
PHST- 2022/09/14 06:00 [medline]
PHST- 2022/09/09 00:00 [pmc-release]
AID - 10.1186/s12940-022-00895-3 [pii]
AID - 895 [pii]
AID - 10.1186/s12940-022-00895-3 [doi]
PST - epublish
SO  - Environ Health. 2022 Sep 9;21(1):83. doi: 10.1186/s12940-022-00895-3.