PMID- 36085420
OWN - NLM
STAT- MEDLINE
DCOM- 20221003
LR  - 20221011
IS  - 1759-4766 (Electronic)
IS  - 1759-4758 (Linking)
VI  - 18
IP  - 10
DP  - 2022 Oct
TI  - The neurovascular unit and systemic biology in stroke - implications for 
      translation and treatment.
PG  - 597-612
LID - 10.1038/s41582-022-00703-z [doi]
AB  - Ischaemic stroke is a leading cause of disability and death for which no acute 
      treatments exist beyond recanalization. The development of novel therapies has 
      been repeatedly hindered by translational failures that have changed the way we 
      think about tissue damage after stroke. What was initially a neuron-centric view 
      has been replaced with the concept of the neurovascular unit (NVU), which 
      encompasses neuronal, glial and vascular compartments, and the biphasic nature of 
      neural-glial-vascular signalling. However, it is now clear that the brain is not 
      the private niche it was traditionally thought to be and that the NVU interacts 
      bidirectionally with systemic biology, such as systemic metabolism, the 
      peripheral immune system and the gut microbiota. Furthermore, these interactions 
      are profoundly modified by internal and external factors, such as ageing, 
      temperature and day-night cycles. In this Review, we propose an extension of the 
      concept of the NVU to include its dynamic interactions with systemic biology. We 
      anticipate that this integrated view will lead to the identification of novel 
      mechanisms of stroke pathophysiology, potentially explain previous translational 
      failures, and improve stroke care by identifying new biomarkers of and treatment 
      targets in stroke.
CI  - (c) 2022. Springer Nature Limited.
FAU - Tiedt, Steffen
AU  - Tiedt S
AUID- ORCID: 0000-0002-8817-8457
AD  - Consortium International pour la Recherche Circadienne sur l'AVC (CIRCA), . 
      steffen.tiedt@med.uni-muenchen.de.
AD  - Institute for Stroke and Dementia Research (ISD), University Hospital, 
      Ludwig-Maximilians-Universitat Munchen, Munich, Germany. 
      steffen.tiedt@med.uni-muenchen.de.
FAU - Buchan, Alastair M
AU  - Buchan AM
AD  - Consortium International pour la Recherche Circadienne sur l'AVC (CIRCA).
AD  - Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
FAU - Dichgans, Martin
AU  - Dichgans M
AD  - Consortium International pour la Recherche Circadienne sur l'AVC (CIRCA).
AD  - Institute for Stroke and Dementia Research (ISD), University Hospital, 
      Ludwig-Maximilians-Universitat Munchen, Munich, Germany.
AD  - German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
AD  - Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
FAU - Lizasoain, Ignacio
AU  - Lizasoain I
AUID- ORCID: 0000-0002-6028-7379
AD  - Consortium International pour la Recherche Circadienne sur l'AVC (CIRCA).
AD  - Department of Pharmacology and Toxicology, Complutense Medical School, Instituto 
      de Investigacion Hospital 12 de Octubre, Madrid, Spain.
FAU - Moro, Maria A
AU  - Moro MA
AD  - Consortium International pour la Recherche Circadienne sur l'AVC (CIRCA).
AD  - Centro Nacional de Investigaciones Cardiovasculares, CNIC, Madrid, Spain.
FAU - Lo, Eng H
AU  - Lo EH
AUID- ORCID: 0000-0002-9327-2915
AD  - Consortium International pour la Recherche Circadienne sur l'AVC (CIRCA), . 
      lo@helix.mgh.harvard.edu.
AD  - Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 
      Boston, MA, USA. lo@helix.mgh.harvard.edu.
AD  - Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 
      Boston, MA, USA. lo@helix.mgh.harvard.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20220909
PL  - England
TA  - Nat Rev Neurol
JT  - Nature reviews. Neurology
JID - 101500072
SB  - IM
MH  - Biology
MH  - Blood-Brain Barrier/metabolism
MH  - Brain
MH  - *Brain Ischemia
MH  - Humans
MH  - Neuroglia
MH  - *Stroke
EDAT- 2022/09/11 06:00
MHDA- 2022/10/04 06:00
CRDT- 2022/09/10 00:03
PHST- 2022/07/22 00:00 [accepted]
PHST- 2022/09/11 06:00 [pubmed]
PHST- 2022/10/04 06:00 [medline]
PHST- 2022/09/10 00:03 [entrez]
AID - 10.1038/s41582-022-00703-z [pii]
AID - 10.1038/s41582-022-00703-z [doi]
PST - ppublish
SO  - Nat Rev Neurol. 2022 Oct;18(10):597-612. doi: 10.1038/s41582-022-00703-z. Epub 
      2022 Sep 9.