PMID- 36085563
OWN - NLM
STAT- MEDLINE
DCOM- 20221104
LR  - 20230320
IS  - 1758-1001 (Electronic)
IS  - 0004-5632 (Linking)
VI  - 59
IP  - 6
DP  - 2022 Nov
TI  - Reference intervals for clinical biochemistry and haematology tests during normal 
      pregnancy.
PG  - 433-446
LID - 10.1177/00045632221128686 [doi]
AB  - BACKGROUND: Pregnancy induces physiological changes which affect biochemical and 
      haematological parameters. As the significance of laboratory test results change 
      throughout pregnancy, the reference interval (RI) or key result interpretive 
      guide should be specific to pregnancy. This study sought to establish 
      trimester-specific-RIs for routine biochemical and haematological tests in 
      healthy white European women with singleton pregnancies with comparison to RIs 
      for non-pregnant European adults. METHODS: A retrospective analysis of a 
      prospective longitudinal single-centre study of healthy pregnant women conducted 
      between November 2018 and December 2020 in a tertiary academic hospital with 
      approximately 3000 births annually. Inclusion criteria: signed informed consent, 
      age >/=18 years, white European, body mass index (BMI) <25 kg/m2, blood pressure 
      <140/90mmHg, non-smoker, no previous pathology or gestational diabetes. Trimester 
      defined as T1: up to 13 weeks + 6 days, T2: 14-27 weeks + 6 days and T3: >/=28-41 
      weeks + 6 days. Baseline demographics, anthropometric and laboratory measurements 
      were recorded. In total, 31 biochemical and 10 haematological ISO15189:2012 
      accredited tests were measured using Roche Cobas(R) and Sysmex XN-9100 analysers, 
      respectively. RIs were established according to the International Federation of 
      Clinical Chemistry (IFCC) recommended method. RESULTS: Apparently healthy 
      pregnant women (n = 124) with bio-banked serum samples in each trimester were 
      recruited. At the booking visit, 49.2% (n = 61) of participants were nulliparous, 
      with median age of 34.4 (IQR: 31.3-37.3) years, gestational age of 89 (IQR: 
      84-93) days, BMI of 22.5 (IQR: 21.0-23.7) kg/m(2) and systolic and diastolic 
      blood pressure of 116 (110-125) mmHg and 67 (61-75) mmHg, respectively. 
      CONCLUSIONS: Normative trimester-specific biological intervals for routinely 
      requested biochemical and haematological medical laboratory tests were 
      established. These RIs will be invaluable to result interpretation and the 
      management of pregnant women.
FAU - Groenendijk, Wendy
AU  - Groenendijk W
AUID- ORCID: 0000-0001-8745-589X
AD  - Department of Clinical Biochemistry, Saolta University Health Care Group (SUHCG), 
      58040Galway University Hospitals, Galway, Ireland.
FAU - Bogdanet, Delia
AU  - Bogdanet D
AUID- ORCID: 0000-0001-6127-5049
AD  - School of Medicine, 8799National University of Ireland Galway (NUIG), Galway, 
      Ireland.
AD  - Centre for Endocrinology, Diabetes and Metabolism, Saolta University Health Care 
      Group (SUHCG), 58040Galway University Hospitals, Galway, Ireland.
FAU - Dervan, Louise
AU  - Dervan L
AD  - School of Medicine, 8799National University of Ireland Galway (NUIG), Galway, 
      Ireland.
FAU - Finn, Oisin
AU  - Finn O
AD  - Department of Clinical Biochemistry, Saolta University Health Care Group (SUHCG), 
      58040Galway University Hospitals, Galway, Ireland.
FAU - Islam, Md Nahidul
AU  - Islam MN
AD  - Department of Clinical Biochemistry, Saolta University Health Care Group (SUHCG), 
      58040Galway University Hospitals, Galway, Ireland.
FAU - Doheny, Helen
AU  - Doheny H
AD  - Department of Clinical Biochemistry, Saolta University Health Care Group (SUHCG), 
      58040Galway University Hospitals, Galway, Ireland.
FAU - Griffin, Tomas P
AU  - Griffin TP
AUID- ORCID: 0000-0003-1625-9394
AD  - School of Medicine, 8799National University of Ireland Galway (NUIG), Galway, 
      Ireland.
AD  - Centre for Endocrinology, Diabetes and Metabolism, Saolta University Health Care 
      Group (SUHCG), 58040Galway University Hospitals, Galway, Ireland.
FAU - Blake, Liam
AU  - Blake L
AD  - Department of Clinical Biochemistry, Saolta University Health Care Group (SUHCG), 
      58040Galway University Hospitals, Galway, Ireland.
FAU - Lyons, Mark
AU  - Lyons M
AD  - Department of Haematology, Saolta University Health Care Group (SUHCG), 
      58040Galway University Hospitals, Galway, Ireland.
FAU - Kilcooley, Mary
AU  - Kilcooley M
AD  - Department of Haematology, Saolta University Health Care Group (SUHCG), 
      58040Galway University Hospitals, Galway, Ireland.
FAU - Krawczyk, Janusz
AU  - Krawczyk J
AD  - School of Medicine, 8799National University of Ireland Galway (NUIG), Galway, 
      Ireland.
AD  - Department of Haematology, Saolta University Health Care Group (SUHCG), 
      58040Galway University Hospitals, Galway, Ireland.
FAU - Gilmore, Ruth
AU  - Gilmore R
AD  - School of Medicine, 8799National University of Ireland Galway (NUIG), Galway, 
      Ireland.
AD  - Department of Haematology, Saolta University Health Care Group (SUHCG), 
      58040Galway University Hospitals, Galway, Ireland.
FAU - Griffin, Damian G
AU  - Griffin DG
AD  - Department of Clinical Biochemistry, Saolta University Health Care Group (SUHCG), 
      58040Galway University Hospitals, Galway, Ireland.
FAU - Gaffney, Geraldine
AU  - Gaffney G
AD  - School of Medicine, 8799National University of Ireland Galway (NUIG), Galway, 
      Ireland.
AD  - Department of Obstetrics and Gynaecology, Saolta University Health Care Group 
      (SUHCG), 58040Galway University Hospitals, Galway, Ireland.
FAU - Dunne, Fidelma P
AU  - Dunne FP
AUID- ORCID: 0000-0003-3682-9403
AD  - School of Medicine, 8799National University of Ireland Galway (NUIG), Galway, 
      Ireland.
AD  - Centre for Endocrinology, Diabetes and Metabolism, Saolta University Health Care 
      Group (SUHCG), 58040Galway University Hospitals, Galway, Ireland.
FAU - O'Shea, Paula M
AU  - O'Shea PM
AUID- ORCID: 0000-0001-9392-1711
AD  - Department of Clinical Biochemistry, Saolta University Health Care Group (SUHCG), 
      58040Galway University Hospitals, Galway, Ireland.
AD  - School of Medicine, 8799National University of Ireland Galway (NUIG), Galway, 
      Ireland.
LA  - eng
PT  - Journal Article
DEP - 20221004
PL  - England
TA  - Ann Clin Biochem
JT  - Annals of clinical biochemistry
JID - 0324055
SB  - IM
CIN - Ann Clin Biochem. 2023 Mar;60(2):146-147. PMID: 36325819
MH  - Adult
MH  - Female
MH  - Pregnancy
MH  - Humans
MH  - Infant
MH  - Adolescent
MH  - Prospective Studies
MH  - Retrospective Studies
MH  - Reference Values
MH  - *Hematologic Tests
MH  - *Hematology
OTO - NOTNLM
OT  - Reference interval
OT  - clinical biochemistry tests
OT  - full blood count
OT  - pregnancy
OT  - trimester-specific
EDAT- 2022/09/11 06:00
MHDA- 2022/11/05 06:00
CRDT- 2022/09/10 00:08
PHST- 2022/09/11 06:00 [pubmed]
PHST- 2022/11/05 06:00 [medline]
PHST- 2022/09/10 00:08 [entrez]
AID - 10.1177/00045632221128686 [doi]
PST - ppublish
SO  - Ann Clin Biochem. 2022 Nov;59(6):433-446. doi: 10.1177/00045632221128686. Epub 
      2022 Oct 4.