PMID- 36085603
OWN - NLM
STAT- MEDLINE
DCOM- 20220913
LR  - 20221011
IS  - 2694-0604 (Electronic)
IS  - 2375-7477 (Linking)
VI  - 2022
DP  - 2022 Jul
TI  - Optical Deformation of Biological Cells using Dual-Beam Laser Tweezer.
PG  - 17-20
LID - 10.1109/EMBC48229.2022.9871373 [doi]
AB  - Optical tweezer is a non-contact tool to trap and manipulate microparticles such 
      as biological cells using coherent light beams. In this study, we utilized a 
      dual-beam optical tweezer, created using two counterpropagating and slightly 
      divergent laser beams to trap and deform biological cells. Human embryonic kidney 
      293 (HEK-293) and breast cancer (SKBR3) cells were used to characterize their 
      membrane elasticity by optically stretching in the dual-beam optical tweezer. It 
      was observed that the extent of deformation in both cell types increases with 
      increasing optical trapping power. The SKBR3 cells exhibited greater percentage 
      deformation than that of HEK-293 cells for a given trapping power. Our results 
      demonstrate that the dual-beam optical tweezer provides measures of cell 
      elasticity that can distinguish between various cell types. The non-contact 
      optical cell stretching can be effectively utilized in disease diagnosis such as 
      cancer based on the cell elasticity measures.
FAU - Bett, Festus
AU  - Bett F
FAU - Brown, Sofia
AU  - Brown S
FAU - Dong, Aotuo
AU  - Dong A
FAU - Christian, Monique
AU  - Christian M
FAU - Ajala, Sunday
AU  - Ajala S
FAU - Santiago, Kevin
AU  - Santiago K
FAU - Albin, Sacharia
AU  - Albin S
FAU - Marz, Aylin
AU  - Marz A
FAU - Deo, Makarand
AU  - Deo M
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Annu Int Conf IEEE Eng Med Biol Soc
JT  - Annual International Conference of the IEEE Engineering in Medicine and Biology 
      Society. IEEE Engineering in Medicine and Biology Society. Annual International 
      Conference
JID - 101763872
SB  - IM
MH  - *Breast Neoplasms
MH  - Elasticity
MH  - Embryo, Mammalian
MH  - Female
MH  - HEK293 Cells
MH  - Humans
MH  - *Optical Tweezers
EDAT- 2022/09/11 06:00
MHDA- 2022/09/14 06:00
CRDT- 2022/09/10 01:03
PHST- 2022/09/10 01:03 [entrez]
PHST- 2022/09/11 06:00 [pubmed]
PHST- 2022/09/14 06:00 [medline]
AID - 10.1109/EMBC48229.2022.9871373 [doi]
PST - ppublish
SO  - Annu Int Conf IEEE Eng Med Biol Soc. 2022 Jul;2022:17-20. doi: 
      10.1109/EMBC48229.2022.9871373.