PMID- 36088993 OWN - NLM STAT- MEDLINE DCOM- 20221013 LR - 20221222 IS - 1096-0953 (Electronic) IS - 0013-9351 (Linking) VI - 215 IP - Pt 2 DP - 2022 Dec TI - Associations of perfluoroalkyl and polyfluoroalkyl substances with gestational hypertension and blood pressure during pregnancy: A cohort study. PG - 114284 LID - S0013-9351(22)01611-5 [pii] LID - 10.1016/j.envres.2022.114284 [doi] AB - Previous studies have reported inconsistent associations between perfluoroalkyl and polyfluoroalkyl substances (PFAS) and gestational hypertension (GH) and blood pressure (BP) during pregnancy. Herein, we aimed to evaluate individual and overall effects of PFAS on GH and longitudinal BP measures during pregnancy. We included 826 pregnant women from the Jiashan Birth Cohort established between 2016 and 2018. Concentrations of thirteen PFAS were quantified using plasma samples collected within 16 weeks of gestation. Longitudinal BP measures were obtained from medical records, and more than nine measurements were available for 85.60% of participants. GH was defined as new-onset hypertension occurring after 20 weeks of gestation. Logistic regression models were used to examine the effect of PFAS on GH, while generalized estimating equation models evaluated the average effect of PFAS on BP in each trimester. The potential effect modification by fetal sex was also examined. Bayesian kernel machine regression (BKMR) and quantile g-computation (QgC) were implemented to explore the overall effect of the PFAS mixture. PFOA, PFOS, and PFHxS presented the highest median concentrations of 11.99, 8.81 and 5.43 ng/mL, respectively. Overall, 5.57% of subjects developed GH. PFOS, PFDA, PFUdA, and PFDoA were significantly associated with lower GH odds, and odds ratios ranged between 0.62 and 0.68. We noted associations between PFAS and lower systolic BP and diastolic BP in the third trimester, with PFDA and PFUdA exhibiting the effect on systolic BP only in pregnant women carrying a female fetus. These associations were further confirmed by BKMR and QgC, showing an inverse overall effect of the PFAS mixture. Higher concentrations of PFAS during early pregnancy were associated with lower GH risk and longitudinal BP measures in the third trimester in a population with relatively high exposure levels. Fetal sex might modify the effects of PFDA and PFUdA on systolic BP in the third trimester. CI - Copyright (c) 2022 Elsevier Inc. All rights reserved. FAU - Yang, Lan AU - Yang L AD - NHC Key Lab. of Reproduction Regulation (Shanghai Institute for Biomedical and Pharmaceutical Technologies), School of Public Health, Fudan University, Shanghai, 200032, China. FAU - Ji, Honglei AU - Ji H AD - NHC Key Lab. of Reproduction Regulation (Shanghai Institute for Biomedical and Pharmaceutical Technologies), School of Public Health, Fudan University, Shanghai, 200032, China. FAU - Liang, Hong AU - Liang H AD - NHC Key Lab. of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Shanghai, 200237, China. FAU - Yuan, Wei AU - Yuan W AD - NHC Key Lab. of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Shanghai, 200237, China. FAU - Song, Xiuxia AU - Song X AD - NHC Key Lab. of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Shanghai, 200237, China. FAU - Li, Xiufeng AU - Li X AD - Jiashan Maternal and Child Health Hospital, Jiaxing, 314199, China. FAU - Niu, Jinbo AU - Niu J AD - Jiashan First People's Hospital, Jiaxing, 314199, China. FAU - Shi, Huijuan AU - Shi H AD - NHC Key Lab. of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Shanghai, 200237, China. FAU - Wen, Sheng AU - Wen S AD - Hubei Provincial Key Laboratory of Applied Toxicology, National Reference Laboratory of Dioxin, Hubei Provincial Center for Disease Control and Prevention, Wuhan, 430079, China. Electronic address: wenshenggy@aliyun.com. FAU - Miao, Maohua AU - Miao M AD - NHC Key Lab. of Reproduction Regulation (Shanghai Institute for Biomedical and Pharmaceutical Technologies), School of Public Health, Fudan University, Shanghai, 200032, China. Electronic address: miaomaohua@163.com. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20220908 PL - Netherlands TA - Environ Res JT - Environmental research JID - 0147621 RN - 0 (Alkanesulfonic Acids) RN - 0 (Environmental Pollutants) RN - 0 (Fluorocarbons) SB - IM MH - *Alkanesulfonic Acids MH - Bayes Theorem MH - Blood Pressure MH - Cohort Studies MH - *Environmental Pollutants/toxicity MH - Female MH - *Fluorocarbons/toxicity MH - Humans MH - *Hypertension, Pregnancy-Induced/chemically induced/epidemiology MH - Pregnancy OTO - NOTNLM OT - Blood pressure OT - Gestational exposure OT - Gestational hypertension OT - Mixture OT - Perfluoroalkyl and polyfluoroalkyl substances COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2022/09/12 06:00 MHDA- 2022/10/14 06:00 CRDT- 2022/09/11 19:33 PHST- 2022/06/11 00:00 [received] PHST- 2022/08/17 00:00 [revised] PHST- 2022/09/03 00:00 [accepted] PHST- 2022/09/12 06:00 [pubmed] PHST- 2022/10/14 06:00 [medline] PHST- 2022/09/11 19:33 [entrez] AID - S0013-9351(22)01611-5 [pii] AID - 10.1016/j.envres.2022.114284 [doi] PST - ppublish SO - Environ Res. 2022 Dec;215(Pt 2):114284. doi: 10.1016/j.envres.2022.114284. Epub 2022 Sep 8.