PMID- 36089645
OWN - NLM
STAT- MEDLINE
DCOM- 20230207
LR  - 20230503
IS  - 1436-6215 (Electronic)
IS  - 1436-6207 (Print)
IS  - 1436-6207 (Linking)
VI  - 62
IP  - 1
DP  - 2023 Feb
TI  - Association of prebiotic fiber intake with colorectal cancer risk: the PrebiotiCa 
      study.
PG  - 455-464
LID - 10.1007/s00394-022-02984-y [doi]
AB  - PURPOSE: To evaluate the association between the intake of specific fibers with 
      prebiotic activity, namely inulin-type fructans (ITFs), fructooligosaccharides 
      (FOSs) and galactooligosaccharides (GOSs), and colorectal cancer risk. METHODS: 
      Within the PrebiotiCa study, we used data from a multicentric case-control study 
      conducted in Italy and including 1953 incident, histologically confirmed, 
      colorectal cancer patients and 4154 hospital controls. The amount of six 
      prebiotic molecules [ITFs, nystose (FOS), kestose (FOS), 
      1F-beta-fructofuranosylnystose (FOS), raffinose (GOS) and stachyose (GOS)] in a 
      variety of foods was quantified via laboratory analyses. Subjects' prebiotic 
      fiber intake was estimated by multiplying food frequency questionnaire intake by 
      the prebiotic content of each food item. The odds ratios (OR) of colorectal 
      cancer for quintiles of intakes were derived from logistic regression models 
      including terms for major confounders and total energy intake. RESULTS: GOSs 
      intake was inversely associated with colorectal cancer risk. The OR for the 
      highest versus the lowest quintile of intake were 0.73 (95% confidence interval, 
      CI 0.58-0.92) for raffinose and 0.64 (95% CI 0.53-0.77) for stachyose, with 
      significant inverse trends across quintiles. No association was found with total 
      ITFs and FOSs. The association with stachyose was stronger for colon (continuous 
      OR = 0.74, 95% CI 0.66-0.83) than rectal cancer (OR = 0.89, 95% CI 0.79-1.02). 
      CONCLUSION: Colorectal cancer risk was inversely associated with the intake of 
      dietary GOSs, but not ITFs and FOSs.
CI  - (c) 2022. The Author(s).
FAU - Turati, Federica
AU  - Turati F
AUID- ORCID: 0000-0002-5841-5773
AD  - Unit of Medical Statistics and Biometry, Fondazione IRCCS Istituto Nazionale dei 
      Tumori di Milano, Milan, Italy. federica.turati@unimi.it.
AD  - Department of Clinical Sciences and Community Health, Universita degli Studi di 
      Milano, Milan, Italy. federica.turati@unimi.it.
FAU - Concina, Federica
AU  - Concina F
AD  - Clinical Epidemiology and Public Health Research Unit, Institute for Maternal and 
      Child Health-IRCCS "Burlo Garofolo", Trieste, Italy.
FAU - Rossi, Marta
AU  - Rossi M
AD  - Department of Clinical Sciences and Community Health, Universita degli Studi di 
      Milano, Milan, Italy.
FAU - Fiori, Federica
AU  - Fiori F
AD  - Department of Medicine, University of Udine, Udine, Italy.
FAU - Parpinel, Maria
AU  - Parpinel M
AD  - Department of Medicine, University of Udine, Udine, Italy.
FAU - Taborelli, Martina
AU  - Taborelli M
AD  - Unit of Cancer Epidemiology, CRO Aviano National Cancer Institute, IRCCS, Aviano, 
      Italy.
FAU - Giacosa, Attilio
AU  - Giacosa A
AD  - Department of Gastroenterology and Clinical Nutrition, Policlinico di Monza, 
      Monza, Italy.
FAU - Crispo, Anna
AU  - Crispo A
AD  - Epidemiology Unit, Istituto Tumori "Fondazione Pascale IRCCS", Naples, Italy.
FAU - Pagan, Eleonora
AU  - Pagan E
AD  - Department of Statistics and Quantitative Methods, University of Milan-Bicocca, 
      Milan, Italy.
FAU - Rosato, Valentina
AU  - Rosato V
AD  - Unit of Medical Statistics and Biometry, Fondazione IRCCS Istituto Nazionale dei 
      Tumori di Milano, Milan, Italy.
FAU - Negri, Eva
AU  - Negri E
AD  - Department of Clinical Sciences and Community Health, Universita degli Studi di 
      Milano, Milan, Italy.
AD  - Department of Medical and Surgical Sciences, University of Bologna, Bologna, 
      Italy.
FAU - La Vecchia, Carlo
AU  - La Vecchia C
AD  - Department of Clinical Sciences and Community Health, Universita degli Studi di 
      Milano, Milan, Italy.
LA  - eng
GR  - GR-2016-02361123/Ministero della Salute/
PT  - Journal Article
DEP - 20220911
PL  - Germany
TA  - Eur J Nutr
JT  - European journal of nutrition
JID - 100888704
RN  - N5O3QU595M (Raffinose)
RN  - 0 (Dietary Fiber)
RN  - 0 (Fructans)
RN  - 9005-80-5 (Inulin)
SB  - IM
MH  - Humans
MH  - Case-Control Studies
MH  - Raffinose
MH  - *Colorectal Neoplasms/epidemiology/prevention & control
MH  - Logistic Models
MH  - Dietary Fiber
MH  - Fructans
MH  - Inulin
MH  - Risk Factors
PMC - PMC9899730
OTO - NOTNLM
OT  - Colorectal cancer
OT  - Diet
OT  - Fiber
OT  - Prebiotics
OT  - Prevention
COIS- The authors declare that they have no conflict of interest.
EDAT- 2022/09/12 06:00
MHDA- 2023/02/08 06:00
PMCR- 2022/09/11
CRDT- 2022/09/11 23:17
PHST- 2022/02/17 00:00 [received]
PHST- 2022/08/03 00:00 [accepted]
PHST- 2022/09/12 06:00 [pubmed]
PHST- 2023/02/08 06:00 [medline]
PHST- 2022/09/11 23:17 [entrez]
PHST- 2022/09/11 00:00 [pmc-release]
AID - 10.1007/s00394-022-02984-y [pii]
AID - 2984 [pii]
AID - 10.1007/s00394-022-02984-y [doi]
PST - ppublish
SO  - Eur J Nutr. 2023 Feb;62(1):455-464. doi: 10.1007/s00394-022-02984-y. Epub 2022 
      Sep 11.