PMID- 36089765
OWN - NLM
STAT- MEDLINE
DCOM- 20221223
LR  - 20221223
IS  - 1097-4598 (Electronic)
IS  - 0148-639X (Linking)
VI  - 66
IP  - 6
DP  - 2022 Dec
TI  - Low T3 syndrome is associated with peripheral neuropathy in patients with type 2 
      diabetes mellitus.
PG  - 723-729
LID - 10.1002/mus.27719 [doi]
AB  - INTRODUCTION/AIMS: Diabetic peripheral neuropathy (DPN) is one of the most common 
      chronic complications of diabetes mellitus. Diabetic patients often have thyroid 
      dysfunction. The aim of this study was to investigate the association between low 
      triiodothyronine (T3) syndrome and DPN in patients with type 2 diabetes mellitus 
      (T2DM). METHODS: A retrospective review was performed of 928 patients with T2DM 
      for whom data was available for clinical manifestations and nerve conduction 
      studies (NCS), and of 134 non-diabetic controls. The composite Z scores of 
      conduction velocity and amplitude were calculated. Low T3 syndrome was defined as 
      T3 levels below the lower limit of the reference interval. RESULTS: Among the 
      patients with T2DM, 632 (68.1%) had DPN, and a larger proportion of these 
      patients presented with low T3 syndrome than patients without DPN. After 
      adjusting for potential confounders, low T3 syndrome was independently associated 
      with the occurrence of DPN (odds ratio [OR] = 2.049, 95% confidence interval [CI] 
      1.319-3.181, p = .001) and the severity of DPN (OR = 1.597, 95% CI 1.030-2.476, 
      p = .036). Adding the criterion of low T3 syndrome improved the prognostic 
      performance of the traditional model (age + gender + diabetic duration + glycated 
      hemoglobin [HbA1c]) for predicting DPN. DISCUSSION: Low T3 syndrome is associated 
      with a higher risk and increased severity of DPN in patients with T2DM. These 
      findings suggest that low T3 syndrome could be a predictor for risk 
      stratification in patients with T2DM.
CI  - (c) 2022 Wiley Periodicals LLC.
FAU - He, Weilei
AU  - He W
AD  - Department of Nuclear Medicine, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, China.
FAU - Pang, Chunyang
AU  - Pang C
AD  - Department of Neurology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, China.
FAU - Chen, Luowei
AU  - Chen L
AUID- ORCID: 0000-0002-5305-7567
AD  - Department of Neurology, The Second Affiliated Hospital of Zhejiang University, 
      Hangzhou, China.
FAU - Zeng, Yaying
AU  - Zeng Y
AD  - Department of Psychiatry, Zhejiang Traditional Chinese Medical Hospital, 
      Hangzhou, China.
FAU - Gao, Lingfei
AU  - Gao L
AD  - Department of Neurology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, China.
FAU - Huang, Huanjie
AU  - Huang H
AD  - Department of Neurology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, China.
FAU - Zhang, Wanli
AU  - Zhang W
AD  - Department of Neurology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, China.
FAU - Wang, Xun
AU  - Wang X
AD  - Department of Neurology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, China.
FAU - Deng, Binbin
AU  - Deng B
AUID- ORCID: 0000-0002-4058-0738
AD  - Department of Neurology, The First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220923
PL  - United States
TA  - Muscle Nerve
JT  - Muscle & nerve
JID - 7803146
RN  - 0 (Glycated Hemoglobin)
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/complications
MH  - *Diabetic Neuropathies/etiology/complications
MH  - *Euthyroid Sick Syndromes/complications
MH  - Glycated Hemoglobin
OTO - NOTNLM
OT  - diabetic peripheral neuropathy
OT  - low T3 syndrome
OT  - nerve conduction study
OT  - severity
OT  - type 2 diabetes mellitus
EDAT- 2022/09/13 06:00
MHDA- 2022/11/22 06:00
CRDT- 2022/09/12 01:46
PHST- 2022/09/02 00:00 [revised]
PHST- 2022/01/25 00:00 [received]
PHST- 2022/09/03 00:00 [accepted]
PHST- 2022/09/13 06:00 [pubmed]
PHST- 2022/11/22 06:00 [medline]
PHST- 2022/09/12 01:46 [entrez]
AID - 10.1002/mus.27719 [doi]
PST - ppublish
SO  - Muscle Nerve. 2022 Dec;66(6):723-729. doi: 10.1002/mus.27719. Epub 2022 Sep 23.