PMID- 36090588
OWN - NLM
STAT- MEDLINE
DCOM- 20220913
LR  - 20220913
IS  - 2314-6753 (Electronic)
IS  - 2314-6745 (Print)
VI  - 2022
DP  - 2022
TI  - The Amelioration of Detrimental Biochemical Anomalies by Supplementing B, C, and 
      E Vitamins in Subjects with Type 2 Diabetes Mellitus May Reduce the Rate of 
      Development of Diabetic Retinopathy.
PG  - 3886710
LID - 10.1155/2022/3886710 [doi]
LID - 3886710
AB  - Excessive intracellular glucose in insulin-independent tissues including nerve, 
      nephron, lens, and retina invites mishandling of metabolism of glucose resulting 
      in a background of increased oxidative stress, advanced glycation end products 
      (AGE) formation, lipid peroxidation, and failure of antioxidant defense systems 
      in type 2 diabetes mellitus (T2DM). All these detrimental biochemical anomalies 
      ultimately attack biological membranes and especially capillary beds of the 
      retina, resulting in the breakdown of the inner blood-retinal barrier and the 
      initiation of diabetic retinopathy (DR). If these disarrays are corrected to a 
      large extent, the development of DR can be avoided or delayed. In this 
      prospective clinical trial, 185 patients with T2DM who received B vitamins, 
      vitamin C, and vitamin E along with antidiabetic medication for five years 
      demonstrated a slower rate of the development of DR and reduced abnormal 
      biochemical mediators like reactive oxygen species (ROS), malondialdehyde (MDA), 
      AGE, and vascular endothelial growth factor (VEGF) compared to 175 T2DM 
      individuals who were treated with only antihyperglycemic drugs.
CI  - Copyright (c) 2022 Subhasish Pramanik et al.
FAU - Pramanik, Subhasish
AU  - Pramanik S
AUID- ORCID: 0000-0003-0641-192X
AD  - Department of Endocrinology & Metabolism, Institute of Post Graduate Medical 
      Education & Research and SSKM Hospital, Kolkata, 700020 West Bengal, India.
FAU - Banerjee, Kaustav
AU  - Banerjee K
AUID- ORCID: 0000-0001-9284-9519
AD  - Decision Sciences Area, Indian Institute of Management Lucknow, Uttar Pradesh 
      226013, India.
FAU - Mondal, Lakshmi Kanta
AU  - Mondal LK
AUID- ORCID: 0000-0003-0057-0778
AD  - Department of Ophthalmology, Regional Institute of Ophthalmology, Medical College 
      Campus, Kolkata, 700073 West Bengal, India.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20220901
PL  - England
TA  - J Diabetes Res
JT  - Journal of diabetes research
JID - 101605237
RN  - 0 (Glycation End Products, Advanced)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 0 (Vitamins)
RN  - 1406-18-4 (Vitamin E)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - *Diabetes Mellitus, Type 2/complications/drug therapy
MH  - *Diabetic Retinopathy/metabolism
MH  - Glucose
MH  - Glycation End Products, Advanced
MH  - Humans
MH  - Hypoglycemic Agents/therapeutic use
MH  - Vascular Endothelial Growth Factor A
MH  - Vitamin E/therapeutic use
MH  - Vitamins/therapeutic use
PMC - PMC9458381
COIS- The authors declare no conflict of interest.
EDAT- 2022/09/13 06:00
MHDA- 2022/09/14 06:00
PMCR- 2022/09/01
CRDT- 2022/09/12 03:45
PHST- 2022/06/13 00:00 [received]
PHST- 2022/08/18 00:00 [accepted]
PHST- 2022/09/12 03:45 [entrez]
PHST- 2022/09/13 06:00 [pubmed]
PHST- 2022/09/14 06:00 [medline]
PHST- 2022/09/01 00:00 [pmc-release]
AID - 10.1155/2022/3886710 [doi]
PST - epublish
SO  - J Diabetes Res. 2022 Sep 1;2022:3886710. doi: 10.1155/2022/3886710. eCollection 
      2022.