PMID- 36090729
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220913
IS  - 1642-395X (Print)
IS  - 2299-0046 (Electronic)
IS  - 1642-395X (Linking)
VI  - 39
IP  - 4
DP  - 2022 Aug
TI  - Clinicopathological characteristics of cutaneous lupus erythematosus patients in 
      Bangladesh.
PG  - 782-787
LID - 10.5114/ada.2021.110254 [doi]
AB  - INTRODUCTION: Nearly all epidemiologic studies have involved patients with 
      systemic lupus erythematosus (SLE). Few authors have investigated the 
      characteristics of patients with cutaneous lupus erythematosus (CLE). AIM: To 
      describe the clinical and pathologic characteristics of a series of patients 
      diagnosed with CLE. MATERIAL AND METHODS: This is a descriptive retrospective 
      cross-sectional study carried out using the consecutive registered records of 218 
      patients attending the 'Lupus Clinic' in Chittagong Medical College Hospital 
      during the period between 2010 and 2020. The activity and damage of CLE were 
      assessed according to the Cutaneous Lupus Erythematosus Disease Area and Severity 
      Index (CLASI). RESULTS: There were 187 (85.8%) females and 31 (14.2%) males, with 
      the female:male ratio being 6 : 1. The mean age was 30.0 +/-11.7 years. The chronic 
      cutaneous lupus erythematosus (CCLE) patients numbered 154 (70.6%), followed by 
      acute cutaneous lupus erythematosus (ACLE) n = 46 (21.1%), and subacute cutaneous 
      lupus erythematosus (SCLE) n = 18 (8.3%). In LE-specific skin lesions, the most 
      common manifestation was photosensitivity, 198 (90.8%), followed by discoid rash, 
      155 (71.1%) and maculo-papular lupus rash, 55 (25.2%). Among LE-nonspecific skin 
      lesions, the most common manifestation was non-scarring alopecia, 123 (56.4%), 
      followed by livedo reticularis, 18 (8.3%), Raynaud's phenomenon, 17 (7.8%), 
      vasculitis, 15 (6.9%), periungual telangiectasia, 7 (3.2%), erythema multiforme, 
      6 (2.7%) and leg ulcers, 5 (2.3%). Antinuclear antibodies (ANA) were the most 
      common type of autoantibody (n = 132, 60.5%) followed by anti-ds DNA (n = 91, 
      41.7%) and anti-phospholipid antibodies (n = 9, 4.1%). CONCLUSIONS: CCLE was the 
      most common subtypes of CLE. Photosensitivity was the most common clinical 
      manifestation, whereas ANA were the most frequent autoantibodies of the LE 
      patients of this region. Patients with different subtypes of CLE have distinct 
      clinical and pathological characteristics.
CI  - Copyright: (c) 2022 Termedia Sp. z o. o.
FAU - Mowla, Mohammad Rafiqul
AU  - Mowla MR
AD  - Department of Dermatology and Venereology, Chittagong Medical College, 
      Chittagong, Bangladesh.
FAU - Barua, Deva Pratim
AU  - Barua DP
AD  - Department of Dermatology and Venereology, Chittagong Medical College, 
      Chittagong, Bangladesh.
FAU - Zaman, Shakila
AU  - Zaman S
AD  - Department of Dermatology and Venereology, Chittagong Medical College, 
      Chittagong, Bangladesh.
FAU - Chowdhury, Mohammad Ismail Hossain
AU  - Chowdhury MIH
AD  - Department of Dermatology and Venereology, Chittagong Medical College, 
      Chittagong, Bangladesh.
FAU - Ara, Shamim
AU  - Ara S
AD  - Chittagong International Medical College, Chittagong, Bangladesh.
FAU - Reich, Adam
AU  - Reich A
AD  - Department of Dermatology, University of Rzeszow, Rzeszow, Poland.
LA  - eng
PT  - Journal Article
DEP - 20211022
PL  - Poland
TA  - Postepy Dermatol Alergol
JT  - Postepy dermatologii i alergologii
JID - 101168357
PMC - PMC9454348
OTO - NOTNLM
OT  - Bangladesh
OT  - Chittagong
OT  - cutaneous lupus erythematosus
COIS- The authors declare no conflict interest.
EDAT- 2022/09/13 06:00
MHDA- 2022/09/13 06:01
PMCR- 2022/08/01
CRDT- 2022/09/12 03:48
PHST- 2021/07/09 00:00 [received]
PHST- 2021/07/21 00:00 [accepted]
PHST- 2022/09/12 03:48 [entrez]
PHST- 2022/09/13 06:00 [pubmed]
PHST- 2022/09/13 06:01 [medline]
PHST- 2022/08/01 00:00 [pmc-release]
AID - 45494 [pii]
AID - 10.5114/ada.2021.110254 [doi]
PST - ppublish
SO  - Postepy Dermatol Alergol. 2022 Aug;39(4):782-787. doi: 10.5114/ada.2021.110254. 
      Epub 2021 Oct 22.