PMID- 36091312
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220913
IS  - 2475-0328 (Electronic)
IS  - 2475-0328 (Linking)
VI  - 6
IP  - 5
DP  - 2022 Sep
TI  - Impact of preoperative skeletal muscle mass and physical performance on 
      short-term and long-term postoperative outcomes in patients with esophageal 
      cancer after esophagectomy.
PG  - 623-632
LID - 10.1002/ags3.12560 [doi]
AB  - BACKGROUND: In patients with esophageal cancer who undergo esophagectomy, 
      preoperative skeletal muscle mass loss has been reported to be associated with 
      postoperative complications and poor prognosis. However, physical performance has 
      not been fully investigated. METHODS: This study included 363 patients who 
      underwent esophagectomy for thoracic esophageal cancer in 2013-2018. Preoperative 
      skeletal muscle index (SMI) was measured with multifrequency bioelectrical 
      impedance. Preoperative 6-minute walk distance (6MWD) was measured as an 
      indicator of physical performance. We investigated the association between these 
      factors and postoperative complications or long-term prognosis. RESULTS: 
      Preoperative SMI was not associated with the occurrence of postoperative 
      complications (33% vs 35%, P = .820), but low preoperative 6MWD was significantly 
      associated with the occurrence of postoperative complications rather than high 
      6MWD (60% vs 30%, P < .001), especially pulmonary complications (23% vs 8%, 
      P = .001). In the analysis of long-term prognosis, low preoperative SMI was 
      associated with poor survival (Hazard ratio [HR] 1.77, P = .004). Low 
      preoperative 6MWD was also associated with poor survival (HR 2.55, P < .001). 
      Multivariate prognostic analysis showed that pT stage (HR 1.97, P = .001), pN 
      stage (HR 3.27, P < .001), and 6MWD (HR 1.93, P = .008) were independent 
      prognostic factors. In the low 6MWD group, the rate of death from other diseases 
      was significantly higher than the other groups. CONCLUSIONS: It is useful to 
      evaluate 6MWD as a physical performance in addition to SMI when evaluating 
      sarcopenia from the perspective of predicting postoperative complications and 
      long-term prognosis in patients with esophageal cancer undergoing esophagectomy.
CI  - (c) 2022 The Authors. Annals of Gastroenterological Surgery published by John Wiley 
      & Sons Australia, Ltd on behalf of The Japanese Society of Gastroenterology.
FAU - Sugimura, Keijiro
AU  - Sugimura K
AUID- ORCID: 0000-0002-5100-9377
AD  - Department of Digestive Surgery Osaka International Cancer Institute Osaka Japan. 
      RINGGOLD: 53312
AD  - Department of Surgery Kansai Rosai Hospital Hyogo Japan.
FAU - Miyata, Hiroshi
AU  - Miyata H
AD  - Department of Digestive Surgery Osaka International Cancer Institute Osaka Japan. 
      RINGGOLD: 53312
FAU - Kanemura, Takashi
AU  - Kanemura T
AD  - Department of Digestive Surgery Osaka International Cancer Institute Osaka Japan. 
      RINGGOLD: 53312
FAU - Takeoka, Tomohira
AU  - Takeoka T
AUID- ORCID: 0000-0002-5153-6740
AD  - Department of Digestive Surgery Osaka International Cancer Institute Osaka Japan. 
      RINGGOLD: 53312
FAU - Shinnno, Naoki
AU  - Shinnno N
AD  - Department of Digestive Surgery Osaka International Cancer Institute Osaka Japan. 
      RINGGOLD: 53312
FAU - Yamamoto, Kazuyoshi
AU  - Yamamoto K
AD  - Department of Digestive Surgery Osaka International Cancer Institute Osaka Japan. 
      RINGGOLD: 53312
FAU - Omori, Takeshi
AU  - Omori T
AUID- ORCID: 0000-0001-5495-6516
AD  - Department of Digestive Surgery Osaka International Cancer Institute Osaka Japan. 
      RINGGOLD: 53312
FAU - Motoori, Masaaki
AU  - Motoori M
AD  - Department of Surgery Osaka General Medical Center Osaka Japan.
FAU - Ohue, Masayuki
AU  - Ohue M
AD  - Department of Digestive Surgery Osaka International Cancer Institute Osaka Japan. 
      RINGGOLD: 53312
FAU - Yano, Masahiko
AU  - Yano M
AD  - Department of Digestive Surgery Osaka International Cancer Institute Osaka Japan. 
      RINGGOLD: 53312
AD  - Department of Surgery Osaka Suita Municipal Hospital Osaka Japan.
LA  - eng
PT  - Journal Article
DEP - 20220308
PL  - Japan
TA  - Ann Gastroenterol Surg
JT  - Annals of gastroenterological surgery
JID - 101718062
PMC - PMC9444856
OTO - NOTNLM
OT  - 6-minute walk distance
OT  - esophageal cancer
OT  - sarcopenia
OT  - skeletal muscle index
EDAT- 2022/09/13 06:00
MHDA- 2022/09/13 06:01
PMCR- 2022/03/08
CRDT- 2022/09/12 03:58
PHST- 2021/12/07 00:00 [received]
PHST- 2022/01/28 00:00 [revised]
PHST- 2022/02/07 00:00 [accepted]
PHST- 2022/09/12 03:58 [entrez]
PHST- 2022/09/13 06:00 [pubmed]
PHST- 2022/09/13 06:01 [medline]
PHST- 2022/03/08 00:00 [pmc-release]
AID - AGS312560 [pii]
AID - 10.1002/ags3.12560 [doi]
PST - epublish
SO  - Ann Gastroenterol Surg. 2022 Mar 8;6(5):623-632. doi: 10.1002/ags3.12560. 
      eCollection 2022 Sep.