PMID- 36092156
OWN - NLM
STAT- MEDLINE
DCOM- 20220913
LR  - 20240118
IS  - 1942-0994 (Electronic)
IS  - 1942-0900 (Print)
IS  - 1942-0994 (Linking)
VI  - 2022
DP  - 2022
TI  - Macrophage Rmp Ameliorates Myocardial Infarction by Modulating Macrophage 
      Polarization in Mice.
PG  - 6248779
LID - 10.1155/2022/6248779 [doi]
LID - 6248779
AB  - BACKGROUND: Inflammation plays important roles during myocardial infarction (MI). 
      Macrophage polarization is a major factor that drives the inflammatory process. 
      Our previous study found that RNA polymerase II subunit 5-mediating protein (RMP) 
      knockout in cardiomyocytes caused heart failure by impairing mitochondrial 
      structure and function. However, whether macrophage RMP plays a role in MI has 
      not been investigated. METHODS: Macrophage RMP-knockout in combination with a 
      mouse model of MI was used to study the function of macrophage RMP in MI. Next, 
      we modified bone marrow-derived macrophages (BMDMs) by plasmid transfection, and 
      the BMDMs were administered to LysM-Cre/DTR mice by tail vein injection. 
      Immunoblotting and immunofluorescence were used to detect macrophage 
      polarization, fibrosis, angiogenesis, and the p38 signaling pathway in each 
      group. RESULTS: Macrophage RMP deficiency aggravates cardiac dysfunction, 
      promotes M1 polarization, and inhibits angiogenesis after MI. However, RMP 
      overexpression in macrophages promotes M2 polarization and angiogenesis after MI. 
      Mechanistically, we found that RMP regulates macrophage polarization through the 
      heat shock protein 90- (HSP90-) p38 signaling pathway. CONCLUSIONS: Macrophage 
      RMP plays a significant role in MI, likely by regulating macrophage polarization 
      via the HSP90-p38 signaling pathway.
CI  - Copyright (c) 2022 Jian Zhang et al.
FAU - Zhang, Jian
AU  - Zhang J
AUID- ORCID: 0000-0002-2875-7713
AD  - Department of Cardiovascular Surgery, General Hospital of Northern Theater 
      Command, No. 83, Wenhua Road, Shenhe District, Shenyang, Liaoning, China.
FAU - Yin, Zongtao
AU  - Yin Z
AD  - Department of Cardiovascular Surgery, General Hospital of Northern Theater 
      Command, No. 83, Wenhua Road, Shenhe District, Shenyang, Liaoning, China.
FAU - Yu, Liming
AU  - Yu L
AD  - Department of Cardiovascular Surgery, General Hospital of Northern Theater 
      Command, No. 83, Wenhua Road, Shenhe District, Shenyang, Liaoning, China.
FAU - Wang, Zhishang
AU  - Wang Z
AD  - Department of Cardiovascular Surgery, General Hospital of Northern Theater 
      Command, No. 83, Wenhua Road, Shenhe District, Shenyang, Liaoning, China.
FAU - Liu, Yu
AU  - Liu Y
AD  - Department of Cardiovascular Surgery, General Hospital of Northern Theater 
      Command, No. 83, Wenhua Road, Shenhe District, Shenyang, Liaoning, China.
FAU - Huang, Xiaoru
AU  - Huang X
AD  - Department of Medicine & Therapeutics, and Li Ka Shing Institute of Health 
      Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong.
FAU - Wan, Song
AU  - Wan S
AUID- ORCID: 0000-0002-9394-1672
AD  - Division of Cardiothoracic Surgery, Department of Surgery, The Chinese University 
      of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong.
FAU - Lan, Hui-Yao
AU  - Lan HY
AUID- ORCID: 0000-0003-4283-9755
AD  - Department of Medicine & Therapeutics, and Li Ka Shing Institute of Health 
      Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong.
FAU - Wang, Huishan
AU  - Wang H
AUID- ORCID: 0000-0001-6523-7488
AD  - Department of Cardiovascular Surgery, General Hospital of Northern Theater 
      Command, No. 83, Wenhua Road, Shenhe District, Shenyang, Liaoning, China.
LA  - eng
PT  - Journal Article
PT  - Retracted Publication
DEP - 20220901
PL  - United States
TA  - Oxid Med Cell Longev
JT  - Oxidative medicine and cellular longevity
JID - 101479826
SB  - IM
RIN - Oxid Med Cell Longev. 2024 Jan 9;2024:9864679. PMID: 38234539
MH  - Animals
MH  - Inflammation/metabolism
MH  - *Macrophage Activation
MH  - Macrophages/metabolism
MH  - Mice
MH  - *Myocardial Infarction/metabolism
MH  - Myocytes, Cardiac/metabolism
PMC - PMC9459438
COIS- The authors have declared that no conflict of interest exists.
EDAT- 2022/09/13 06:00
MHDA- 2022/09/14 06:00
PMCR- 2022/09/01
CRDT- 2022/09/12 04:12
PHST- 2022/05/23 00:00 [received]
PHST- 2022/08/01 00:00 [revised]
PHST- 2022/08/12 00:00 [accepted]
PHST- 2022/09/12 04:12 [entrez]
PHST- 2022/09/13 06:00 [pubmed]
PHST- 2022/09/14 06:00 [medline]
PHST- 2022/09/01 00:00 [pmc-release]
AID - 10.1155/2022/6248779 [doi]
PST - epublish
SO  - Oxid Med Cell Longev. 2022 Sep 1;2022:6248779. doi: 10.1155/2022/6248779. 
      eCollection 2022.