PMID- 36098098
OWN - NLM
STAT- MEDLINE
DCOM- 20220914
LR  - 20220914
IS  - 2304-3873 (Electronic)
IS  - 2304-3865 (Linking)
VI  - 11
IP  - 4
DP  - 2022 Aug
TI  - The challenging surgical management of hepatic epithelioid hemangioendothelioma: 
      a narrative review.
PG  - 27
LID - 10.21037/cco-21-139 [doi]
AB  - BACKGROUND AND OBJECTIVE: Hepatic epithelioid hemangioendothelioma (HEHE) is an 
      uncommon vascular endothelial cell cancer involving the hepatic tissue with full 
      malignant potential. HEHE diagnosis is challenging because blood tests and 
      radiological findings are often non-pathognomonic. Therapeutic possibilities are 
      manifold, ranging from a simple "wait and see" to surgical approaches, up to 
      systemic therapies with vascular endothelial growth factor (VEGF) and mechanistic 
      target of rapamycin (mTOR) inhibitors. The standardized adoption of the surgical 
      approaches, namely resection or transplantation, still remains unclear. Aim of 
      this review is to clarify the role of the surgical strategies for the management 
      of HEHE. METHODS: A review of the literature was done with the intent to focus on 
      the relevant studies exploring the role of the different surgical therapies. A 
      search of these studies was done using the electronic database MEDLINE-PubMed. 
      KEY CONTENT AND FINDINGS: The surgical approaches, namely resection or 
      transplantation, represent the best option in treating well-selected patients 
      with HEHE. Resection is indicated in the case of single lesion or oligonodular 
      monolobar disease. Liver transplantation is indicated in the case of multifocal 
      bilobar disease, even in the presence of resectable extrahepatic disease. The 
      potential role of a minimally invasive approach should represent a relevant field 
      to explore. CONCLUSIONS: The impact of surgery for the treatment of HEHE requires 
      further studies to further clarify its relevant role. Standardized approaches are 
      required.
FAU - Giovanardi, Francesco
AU  - Giovanardi F
AD  - General Surgery and Organ Transplantation Unit, Department of General and 
      Specialistic Surgery, Sapienza University of Rome, Umberto I Polyclinic of Rome, 
      Rome, Italy.
FAU - Larghi Laureiro, Zoe
AU  - Larghi Laureiro Z
AD  - General Surgery and Organ Transplantation Unit, Department of General and 
      Specialistic Surgery, Sapienza University of Rome, Umberto I Polyclinic of Rome, 
      Rome, Italy.
FAU - Meo, Gerardina Anna
AU  - Meo GA
AD  - General Surgery and Organ Transplantation Unit, Department of General and 
      Specialistic Surgery, Sapienza University of Rome, Umberto I Polyclinic of Rome, 
      Rome, Italy.
FAU - Hassan, Redan
AU  - Hassan R
AD  - General Surgery and Organ Transplantation Unit, Department of General and 
      Specialistic Surgery, Sapienza University of Rome, Umberto I Polyclinic of Rome, 
      Rome, Italy.
FAU - Lai, Quirino
AU  - Lai Q
AD  - General Surgery and Organ Transplantation Unit, Department of General and 
      Specialistic Surgery, Sapienza University of Rome, Umberto I Polyclinic of Rome, 
      Rome, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - China
TA  - Chin Clin Oncol
JT  - Chinese clinical oncology
JID - 101608375
RN  - 0 (Vascular Endothelial Growth Factor A)
SB  - IM
MH  - *Hemangioendothelioma, Epithelioid/diagnosis/pathology/surgery
MH  - Humans
MH  - *Liver Neoplasms/drug therapy
MH  - *Liver Transplantation
MH  - Treatment Outcome
MH  - Vascular Endothelial Growth Factor A/therapeutic use
OTO - NOTNLM
OT  - Hemangioendothelioma
OT  - liver transplantation (LT)
OT  - mini-invasive
OT  - resection
EDAT- 2022/09/14 06:00
MHDA- 2022/09/15 06:00
CRDT- 2022/09/13 05:43
PHST- 2021/10/12 00:00 [received]
PHST- 2022/08/22 00:00 [accepted]
PHST- 2022/09/13 05:43 [entrez]
PHST- 2022/09/14 06:00 [pubmed]
PHST- 2022/09/15 06:00 [medline]
AID - 10.21037/cco-21-139 [doi]
PST - ppublish
SO  - Chin Clin Oncol. 2022 Aug;11(4):27. doi: 10.21037/cco-21-139.