PMID- 36099984
OWN - NLM
STAT- MEDLINE
DCOM- 20221013
LR  - 20221013
IS  - 1879-1298 (Electronic)
IS  - 0045-6535 (Linking)
VI  - 308
IP  - Pt 2
DP  - 2022 Dec
TI  - Assessment of health risk and dose-effect of DNA oxidative damage for the thirty 
      chemicals mixture of parabens, triclosan, benzophenones, and phthalate esters.
PG  - 136394
LID - S0045-6535(22)02887-9 [pii]
LID - 10.1016/j.chemosphere.2022.136394 [doi]
AB  - Humans are constantly exposed to parabens (PBs), triclosan (TCS), benzophenones 
      (BPs), and phthalate esters (PAEs) due to the widespread existence of these 
      chemicals in personal care products (PCPs), and the high frequency of usage for 
      humans. Previous studies indicated each class of the above-mentioned chemicals 
      can exhibit potential adverse effects on humans, in particular DNA oxidative 
      damage. However, the health risk assessment of combined exposures to multiple 
      PCPs is limited, especially the overall dose-effect of mixtures of these 
      chemicals on DNA oxidative damage. In this study, we measured the urinary levels 
      of 6 PBs, TCS, 8 BPs, 15 metabolites of PAEs (mono-PAEs), and 
      8-hydroxy-2'-deoxyguanosine (8-OHdG) from 299 adults simultaneously. PBs, TCS, 
      BPs, and mono-PAEs were frequently detected in urinary samples with median 
      concentrations of 52.888, 0.737, 1.305, and 141.381 ng/ml, suggesting a broad, 
      low-level exposure among participants. Risk assessments indicated approximately 
      22% and 15% of participants suffered health risks (Hazard index >1) from exposure 
      to TCS and PAEs. The relationship between 8-OHdG levels and chemical exposure was 
      estimated by Bayesian kernel machine regression (BKMR) models. It indicated an 
      overall positive correlation between the mixture of these chemicals and 8-OHdG, 
      with methylparaben and mono-benzyl phthalate contributing the most to this 
      association. Of note, sex-related differences were observed, in which exposure to 
      PCPs led to higher health risks and more pronounced dose-effect on DNA damage in 
      the female population. Our novel findings reveal the health risks of exposure to 
      low-level PCPs mixtures and further point out the overall dose-response 
      relationship between DNA oxidative damage and PCP mixtures.
CI  - Copyright (c) 2022 Elsevier Ltd. All rights reserved.
FAU - Liao, Qilong
AU  - Liao Q
AD  - Department of Occupational and Environmental Health, School of Public Health, Sun 
      Yat-Sen University, No. 74 Zhongshan Road 2, Guangzhou, 510080, China; Guangdong 
      Provincial Key Laboratory of Food, Nutrition, and Health, School of Public 
      Health, Sun Yat-sen University, No. 74 Zhongshan Road 2, Guangzhou, 510080, 
      Guangdong, China.
FAU - Huang, Hehai
AU  - Huang H
AD  - Department of Occupational and Environmental Health, School of Public Health, Sun 
      Yat-Sen University, No. 74 Zhongshan Road 2, Guangzhou, 510080, China.
FAU - Zhang, Xue
AU  - Zhang X
AD  - Department of Occupational and Environmental Health, School of Public Health, Sun 
      Yat-Sen University, No. 74 Zhongshan Road 2, Guangzhou, 510080, China.
FAU - Ma, Xiaoju
AU  - Ma X
AD  - Department of Occupational and Environmental Health, School of Public Health, Sun 
      Yat-Sen University, No. 74 Zhongshan Road 2, Guangzhou, 510080, China.
FAU - Peng, Jing
AU  - Peng J
AD  - Department of Occupational and Environmental Health, School of Public Health, Sun 
      Yat-Sen University, No. 74 Zhongshan Road 2, Guangzhou, 510080, China.
FAU - Zhang, Zhaorui
AU  - Zhang Z
AD  - Department of Occupational and Environmental Health, School of Public Health, Sun 
      Yat-Sen University, No. 74 Zhongshan Road 2, Guangzhou, 510080, China.
FAU - Chen, Chuanying
AU  - Chen C
AD  - Department of Occupational and Environmental Health, School of Public Health, Sun 
      Yat-Sen University, No. 74 Zhongshan Road 2, Guangzhou, 510080, China.
FAU - Lv, Yanrong
AU  - Lv Y
AD  - Department of Occupational and Environmental Health, School of Public Health, Sun 
      Yat-Sen University, No. 74 Zhongshan Road 2, Guangzhou, 510080, China.
FAU - Zhu, Xiaohui
AU  - Zhu X
AD  - State Environmental Protection Key Laboratory of Environmental Pollution Health 
      Risk Assessment, South China Institute of Environmental Sciences, Ministry of 
      Ecology and Environment, Guangzhou, 510655, China.
FAU - Zheng, Jing
AU  - Zheng J
AD  - State Environmental Protection Key Laboratory of Environmental Pollution Health 
      Risk Assessment, South China Institute of Environmental Sciences, Ministry of 
      Ecology and Environment, Guangzhou, 510655, China.
FAU - Zeng, Xiaowen
AU  - Zeng X
AD  - Department of Occupational and Environmental Health, School of Public Health, Sun 
      Yat-Sen University, No. 74 Zhongshan Road 2, Guangzhou, 510080, China.
FAU - Xing, Xiumei
AU  - Xing X
AD  - Department of Occupational and Environmental Health, School of Public Health, Sun 
      Yat-Sen University, No. 74 Zhongshan Road 2, Guangzhou, 510080, China.
FAU - Deng, Qifei
AU  - Deng Q
AD  - Department of Occupational and Environmental Health, School of Public Health, Sun 
      Yat-Sen University, No. 74 Zhongshan Road 2, Guangzhou, 510080, China; Guangdong 
      Provincial Key Laboratory of Food, Nutrition, and Health, School of Public 
      Health, Sun Yat-sen University, No. 74 Zhongshan Road 2, Guangzhou, 510080, 
      Guangdong, China.
FAU - Dong, Guanghui
AU  - Dong G
AD  - Department of Occupational and Environmental Health, School of Public Health, Sun 
      Yat-Sen University, No. 74 Zhongshan Road 2, Guangzhou, 510080, China.
FAU - Wei, Qing
AU  - Wei Q
AD  - Guangdong Provincial Key Laboratory of Food, Nutrition, and Health, School of 
      Public Health, Sun Yat-sen University, No. 74 Zhongshan Road 2, Guangzhou, 
      510080, Guangdong, China.
FAU - Hou, Mengjun
AU  - Hou M
AD  - Guangdong Provincial Key Laboratory of Food, Nutrition, and Health, School of 
      Public Health, Sun Yat-sen University, No. 74 Zhongshan Road 2, Guangzhou, 
      510080, Guangdong, China.
FAU - Xiao, Yongmei
AU  - Xiao Y
AD  - Department of Occupational and Environmental Health, School of Public Health, Sun 
      Yat-Sen University, No. 74 Zhongshan Road 2, Guangzhou, 510080, China; Guangdong 
      Provincial Key Laboratory of Food, Nutrition, and Health, School of Public 
      Health, Sun Yat-sen University, No. 74 Zhongshan Road 2, Guangzhou, 510080, 
      Guangdong, China. Electronic address: xiaoym@mail.sysu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20220910
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 0 (Benzophenones)
RN  - 0 (Cosmetics)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Esters)
RN  - 0 (Parabens)
RN  - 0 (Phthalic Acids)
RN  - 4NM5039Y5X (Triclosan)
RN  - 6O7F7IX66E (phthalic acid)
RN  - 88847-89-6 (8-Hydroxy-2'-Deoxyguanosine)
SB  - IM
MH  - 8-Hydroxy-2'-Deoxyguanosine
MH  - Adult
MH  - Bayes Theorem
MH  - Benzophenones/toxicity/urine
MH  - *Cosmetics
MH  - Environmental Exposure/analysis
MH  - *Environmental Pollutants/urine
MH  - Esters/toxicity
MH  - Female
MH  - Humans
MH  - Oxidative Stress
MH  - Parabens/analysis
MH  - *Phthalic Acids/metabolism
MH  - *Triclosan/toxicity
OTO - NOTNLM
OT  - 8-OHdG
OT  - Dose-effect
OT  - Key pollutant
OT  - Mixture risk assessment
OT  - Sex difference
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2022/09/14 06:00
MHDA- 2022/10/14 06:00
CRDT- 2022/09/13 19:13
PHST- 2022/06/06 00:00 [received]
PHST- 2022/09/04 00:00 [revised]
PHST- 2022/09/06 00:00 [accepted]
PHST- 2022/09/14 06:00 [pubmed]
PHST- 2022/10/14 06:00 [medline]
PHST- 2022/09/13 19:13 [entrez]
AID - S0045-6535(22)02887-9 [pii]
AID - 10.1016/j.chemosphere.2022.136394 [doi]
PST - ppublish
SO  - Chemosphere. 2022 Dec;308(Pt 2):136394. doi: 10.1016/j.chemosphere.2022.136394. 
      Epub 2022 Sep 10.