PMID- 36100550
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231110
IS  - 2531-1387 (Electronic)
IS  - 2531-1379 (Print)
IS  - 2531-1379 (Linking)
VI  - 45
IP  - 4
DP  - 2023 Oct-Dec
TI  - Natural killer cells 56(bright)16(-) have higher counts in the umbilical cord 
      blood than in the adult peripheral blood.
PG  - 419-427
LID - S2531-1379(22)00110-9 [pii]
LID - 10.1016/j.htct.2022.07.001 [doi]
AB  - INTRODUCTION AND HYPOTHESIS: Umbilical cord blood (UCB) is an alternative source 
      of hematopoietic stem cells for allogeneic hematopoietic stem cell 
      transplantation in the absence of a compatible donor. The UCB transplantation has 
      a lower incidence of chronic graft versus host disease (GvHD), but is associated 
      with slower engraftment and slower immune reconstitution, compared to other 
      sources. Dendritic cells (DCs) and Natural Killer cells (NKs) play a central role 
      in the development of GvHD and the graft versus leukemia (GvL) effect, as well as 
      in the control of infectious complications. METHOD: We quantified by 
      multiparametric flow cytometry monocytes, lymphocytes, NK cells, and DCs, 
      including their subsets, in UCB samples from 54 healthy newborns and peripheral 
      blood (PB) from 25 healthy adult volunteers. RESULTS: In the UCB samples, there 
      were higher counts of NK cells 56(bright)16(-) (median 0.024 x 109/L), compared 
      to the PB samples (0.012 x 109/L, p < 0.0001), NK 56(dim)16(bright) (median 
      0.446 x 109/L vs. 0.259 x 109/L for PB samples, p = 0.001) and plasmacytoid 
      dendritic cells (pDCs, median 0.008 x 109/L for UCB samples vs. 0.006 x 109/L for 
      PB samples, p = 0.03). Moreover, non-classic monocyte counts were lower in UCB 
      than in PB (median 0.024 x 109/L vs. 0.051 x 109/L, respectively, p < 0.0001). 
      CONCLUSION: In conclusion, there were higher counts of NK cells and pDCs and 
      lower counts of non-classic monocytes in UCB than in PB from healthy individuals. 
      These findings might explain the lower incidence and severity of chronic GvHD, 
      although maintaining the GvL effect, in UCB transplant recipients, compared to 
      other stem cell sources.
CI  - Copyright (c) 2022 Associacao Brasileira de Hematologia, Hemoterapia e Terapia 
      Celular. Published by Elsevier Espana, S.L.U. All rights reserved.
FAU - de Molla, Vinicius Campos
AU  - de Molla VC
AD  - Universidade Federal de Sao Paulo (Unifesp), Sao Paulo, SP, Brazil; Hospital 9 de 
      Julho, Sao Paulo, Brazil.
FAU - Barbosa, Miriam Cristina Rodrigues
AU  - Barbosa MCR
AD  - Universidade Federal de Sao Paulo (Unifesp), Sao Paulo, SP, Brazil.
FAU - Junior, Alfredo Mendrone
AU  - Junior AM
AD  - Hospital 9 de Julho, Sao Paulo, Brazil.
FAU - Goncalves, Matheus Vescovi
AU  - Goncalves MV
AD  - Universidade Federal de Sao Paulo (Unifesp), Sao Paulo, SP, Brazil.
FAU - Guirao, Eliza Kimuraa Fabio
AU  - Guirao EKF
AD  - Universidade Federal de Sao Paulo (Unifesp), Sao Paulo, SP, Brazil.
FAU - Yamamoto, Mihoko
AU  - Yamamoto M
AD  - Universidade Federal de Sao Paulo (Unifesp), Sao Paulo, SP, Brazil.
FAU - Arrais-Rodrigues, Celso
AU  - Arrais-Rodrigues C
AD  - Universidade Federal de Sao Paulo (Unifesp), Sao Paulo, SP, Brazil; Hospital 9 de 
      Julho, Sao Paulo, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20220819
PL  - Brazil
TA  - Hematol Transfus Cell Ther
JT  - Hematology, transfusion and cell therapy
JID - 101725732
PMC - PMC10627873
OTO - NOTNLM
OT  - Natural killer cells
OT  - Peripheral blood
OT  - Plasmacytoid dendritic cell
OT  - Umbilical cord blood
COIS- Conflicts of interest There are no conflicts of interest to report.
EDAT- 2022/09/14 06:00
MHDA- 2022/09/14 06:01
PMCR- 2022/08/19
CRDT- 2022/09/13 22:06
PHST- 2022/01/31 00:00 [received]
PHST- 2022/06/05 00:00 [revised]
PHST- 2022/07/03 00:00 [accepted]
PHST- 2022/09/14 06:01 [medline]
PHST- 2022/09/14 06:00 [pubmed]
PHST- 2022/09/13 22:06 [entrez]
PHST- 2022/08/19 00:00 [pmc-release]
AID - S2531-1379(22)00110-9 [pii]
AID - 10.1016/j.htct.2022.07.001 [doi]
PST - ppublish
SO  - Hematol Transfus Cell Ther. 2023 Oct-Dec;45(4):419-427. doi: 
      10.1016/j.htct.2022.07.001. Epub 2022 Aug 19.