PMID- 36100932
OWN - NLM
STAT- MEDLINE
DCOM- 20220915
LR  - 20231001
IS  - 1833-3516 (Print)
IS  - 2209-1491 (Electronic)
IS  - 1833-3516 (Linking)
VI  - 52
IP  - 3
DP  - 2022 Sep 30
TI  - Effect of hyperbaric oxygen treatment on skin elasticity in irradiated patients.
PG  - 208-212
LID - 10.28920/dhm52.3.208-212 [doi]
AB  - BACKGROUND: Hyperbaric oxygen treatment (HBOT) is often used in an attempt to 
      reverse/treat late radiation-induced tissue fibrosis (LRITF). This study aimed to 
      quantify the effects on skin elasticity. METHODS: Skin retraction time was used 
      as a marker of skin elasticity in 13 irradiated breast cancer patients. The 
      measurements were carried out on the affected side as well as the 
      unaffected/healthy side at a mirrored location. Readings were taken at the start 
      and end of HBOT (mean 43 sessions, 80 min at 243 kPa). RESULTS: Patient age 
      ranged from 39-70 years. All patients underwent surgical lumpectomy and 
      radiotherapy prior to undergoing HBOT. The mean time between radiotherapy and 
      HBOT was 70 months. Seven of the 13 patients underwent chemotherapy. Mean 
      irradiated skin retraction time improved from 417 (SD 158) pre-HBOT to 171 (24) 
      msec post-HBOT (P < 0.001). Mean pre-HBOT retraction time in the non-irradiated 
      skin was 143 (20) msec and did not change. CONCLUSIONS: This promising pilot 
      study that suggests that HBOT may improve skin elasticity in patients with LRITF.
CI  - Copyright: This article is the copyright of the authors who grant Diving and 
      Hyperbaric Medicine a non-exclusive licence to publish the article in electronic 
      and other forms.
FAU - Pandey, Karan
AU  - Pandey K
AD  - Department of Surgery/Hyperbaric Medicine, Amsterdam University Medical Centre, 
      Location AMC, Amsterdam, The Netherlands.
AD  - Corresponding author: Karan Pandey, Department of Hyperbaric Medicine, Amsterdam 
      University Medical Centre, Location AMC, Amsterdam, The Netherlands, 
      k.pandey@student.vu.nl.
FAU - Teguh, David N
AU  - Teguh DN
AD  - Department of Surgery/Hyperbaric Medicine, Amsterdam University Medical Centre, 
      Location AMC, Amsterdam, The Netherlands.
FAU - van Hulst, Robert A
AU  - van Hulst RA
AD  - Department of Surgery/Hyperbaric Medicine, Amsterdam University Medical Centre, 
      Location AMC, Amsterdam, The Netherlands.
AD  - Department of Anesthesiology, Amsterdam University Medical Center, Location AMC, 
      Amsterdam, The Netherlands.
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Diving Hyperb Med
JT  - Diving and hyperbaric medicine
JID - 101282742
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Elasticity
MH  - Humans
MH  - *Hyperbaric Oxygenation
MH  - Middle Aged
MH  - Oxygen
MH  - Pilot Projects
MH  - *Radiation Injuries/therapy
PMC - PMC9722336
OTO - NOTNLM
OT  - Breast cancer
OT  - Fibrosis
OT  - Late radiation tissue injuries
OT  - Radionecrosis
OT  - Radiotherapy
COIS- Conflict of interest and funding: nil
EDAT- 2022/09/14 06:00
MHDA- 2022/09/16 06:00
PMCR- 2023/09/30
CRDT- 2022/09/13 23:38
PHST- 2022/01/07 00:00 [received]
PHST- 2022/05/06 00:00 [accepted]
PHST- 2022/09/13 23:38 [entrez]
PHST- 2022/09/14 06:00 [pubmed]
PHST- 2022/09/16 06:00 [medline]
PHST- 2023/09/30 00:00 [pmc-release]
AID - 10.28920/dhm52.3.208-212 [doi]
PST - ppublish
SO  - Diving Hyperb Med. 2022 Sep 30;52(3):208-212. doi: 10.28920/dhm52.3.208-212.