PMID- 36101424
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220917
IS  - 2079-7737 (Print)
IS  - 2079-7737 (Electronic)
IS  - 2079-7737 (Linking)
VI  - 11
IP  - 7
DP  - 2022 Jul 12
TI  - Confocal Characterization of Intestinal Dendritic Cells from Myxines to Teleosts.
LID - 10.3390/biology11071045 [doi]
LID - 1045
AB  - Dendritic cells (DCs) are antigen-presenting cells (APCs) that regulate the 
      beginning of adaptive immune responses. The mechanisms of tolerance to antigens 
      moving through the digestive tract are known to be regulated by intestinal DCs. 
      Agnatha and Gnathostoma are descendants of a common ancestor. The Ostracoderms 
      gave rise to Cyclostomes, whereas the Placoderms gave rise to Chondrichthyes. 
      Sarcopterygii and Actinopterygii are two evolutionary lines of bony fishes. 
      Brachiopterygii and Neopterygii descend from the Actinopterygii. From 
      Neopterygii, Holostei and Teleostei evolved. Using immunohistochemistry with 
      TLR-2, Langerin/CD207, and MHC II, this study aimed to characterize intestinal 
      DCs, from myxines to teleosts. The findings reveal that DCs are positive for the 
      antibodies tested, highlighting the presence of DCs and DC-like cells 
      phylogenetically from myxines, for the first time, to teleosts. These findings 
      may aid in improving the level of knowledge about the immune system's evolution 
      and these sentinel cells, which are crucial to the body's defense.
FAU - Alesci, Alessio
AU  - Alesci A
AUID- ORCID: 0000-0002-7580-8114
AD  - Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, 
      University of Messina, 98166 Messina, Italy.
FAU - Capillo, Gioele
AU  - Capillo G
AUID- ORCID: 0000-0002-2002-1138
AD  - Department of Veterinary Sciences, University of Messina, 98168 Messina, Italy.
AD  - Institute of Marine Biological Resources and Biotechnology, National Research 
      Council (IRBIM, CNR), 98164 Messina, Italy.
FAU - Fumia, Angelo
AU  - Fumia A
AUID- ORCID: 0000-0001-5815-5302
AD  - Department of Clinical and Experimental Medicine, University of Messina, 
      Padiglione C, A. O. U. Policlinico "G. Martino", 98124 Messina, Italy.
FAU - Messina, Emmanuele
AU  - Messina E
AD  - Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, 
      University of Messina, 98166 Messina, Italy.
FAU - Albano, Marco
AU  - Albano M
AUID- ORCID: 0000-0003-0635-2755
AD  - Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, 
      University of Messina, 98166 Messina, Italy.
FAU - Aragona, Marialuisa
AU  - Aragona M
AUID- ORCID: 0000-0001-5551-9326
AD  - Department of Veterinary Sciences, University of Messina, 98168 Messina, Italy.
FAU - Lo Cascio, Patrizia
AU  - Lo Cascio P
AUID- ORCID: 0000-0003-3686-6087
AD  - Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, 
      University of Messina, 98166 Messina, Italy.
FAU - Spano, Nunziacarla
AU  - Spano N
AUID- ORCID: 0000-0002-8360-4795
AD  - Institute of Marine Biological Resources and Biotechnology, National Research 
      Council (IRBIM, CNR), 98164 Messina, Italy.
AD  - Department of Biomedical, Dental and Morphological and Functional Imaging, 
      University of Messina, 98125 Messina, Italy.
FAU - Pergolizzi, Simona
AU  - Pergolizzi S
AUID- ORCID: 0000-0002-6884-634X
AD  - Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, 
      University of Messina, 98166 Messina, Italy.
FAU - Lauriano, Eugenia Rita
AU  - Lauriano ER
AD  - Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, 
      University of Messina, 98166 Messina, Italy.
LA  - eng
PT  - Journal Article
DEP - 20220712
PL  - Switzerland
TA  - Biology (Basel)
JT  - Biology
JID - 101587988
PMC - PMC9312193
OTO - NOTNLM
OT  - comparative immunology
OT  - confocal microscopy
OT  - dendritic cells
OT  - evolution
OT  - immunity
COIS- The authors declare no conflict of interest.
EDAT- 2022/09/15 06:00
MHDA- 2022/09/15 06:01
PMCR- 2022/07/12
CRDT- 2022/09/14 01:11
PHST- 2022/06/03 00:00 [received]
PHST- 2022/07/01 00:00 [revised]
PHST- 2022/07/07 00:00 [accepted]
PHST- 2022/09/14 01:11 [entrez]
PHST- 2022/09/15 06:00 [pubmed]
PHST- 2022/09/15 06:01 [medline]
PHST- 2022/07/12 00:00 [pmc-release]
AID - biology11071045 [pii]
AID - biology-11-01045 [pii]
AID - 10.3390/biology11071045 [doi]
PST - epublish
SO  - Biology (Basel). 2022 Jul 12;11(7):1045. doi: 10.3390/biology11071045.