PMID- 36101997
OWN - NLM
STAT- MEDLINE
DCOM- 20230118
LR  - 20230118
IS  - 1099-1573 (Electronic)
IS  - 0951-418X (Linking)
VI  - 37
IP  - 1
DP  - 2023 Jan
TI  - The effects of rutin flavonoid supplement on glycemic status, lipid profile, 
      atherogenic index of plasma, brain-derived neurotrophic factor (BDNF), some serum 
      inflammatory, and oxidative stress factors in patients with type 2 diabetes 
      mellitus: A double-blind, placebo-controlled trial.
PG  - 271-284
LID - 10.1002/ptr.7611 [doi]
AB  - This study aimed to investigate the effects of rutin flavonoid in type 2 diabetes 
      mellitus (T2DM) patients. In this trial (double-blind, placebo-controlled), 50 
      T2DM patients (supplement, n = 25 and placebo, n = 25) were randomized and 
      supplemented with 500 mg rutin or placebo per day for 3-months. At the beginning 
      and at the end of the study, metabolic parameters including fasting blood glucose 
      (FBG), insulin, glycosylated hemoglobin (HbA1c), homeostasis model assessment of 
      insulin resistance (HOMO-IR), quantitative insulin sensitivity check index 
      (QUICKI), homeostasis model assessment of beta-cell function (HOMA-beta), triglyceride 
      (TG), total cholesterol (CHOL), high-density and low-density lipoprotein 
      cholesterol (HDL-c and LDL-c), and atherogenic index of plasma (AIP), 
      inflammatory and oxidative stress markers such as interleukin 6 (IL-6), total 
      antioxidant capacity (TAC), and malondialdehyde (MDA) and brain-derived 
      neurotrophic factor (BDNF) were assessed. The results showed a significant 
      decrease in FBG, insulin, HbA1c, HOMO-IR, LDL-c, TG, VLDL, CHOL, LDL-c.HDL-c 
      ratio, AIP, IL-6, and MDA and a significant increase in HDL-c, QUICKI index, 
      BDNF, and TAC compared with the initial value (p for all <.05). In the adjusted 
      model, the mean changes of FBG, insulin, HbA1c, HOMO-IR, LDL-c, CHOL, LDL.HDL 
      ratio, AIP, MDA, and IL-6 were significantly lower and mean changes of QUICKI 
      index, HDL-c, and TAC were significantly higher in the rutin group compared with 
      the placebo group (adjusted p for all <.05). It seems that rutin may have 
      beneficial effects on improving metabolic parameters, BDNF, and inflammatory and 
      oxidative stress factors in T2DM patients.
CI  - (c) 2022 John Wiley & Sons Ltd.
FAU - Bazyar, Hadi
AU  - Bazyar H
AUID- ORCID: 0000-0002-1627-7122
AD  - Nutrition and Metabolic Diseases Research Center, Clinical Sciences Research 
      Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
AD  - Student Research Committee, Ahvaz Jundishapur University of Medical Science, 
      Ahvaz, Iran.
FAU - Moradi, Leila
AU  - Moradi L
AD  - Health Research Institute, Diabetes Research Center, Ahvaz Jundishapur University 
      of Medical Sciences, Ahvaz, Iran.
FAU - Zaman, Ferdows
AU  - Zaman F
AD  - Health Research Institute, Diabetes Research Center, Ahvaz Jundishapur University 
      of Medical Sciences, Ahvaz, Iran.
FAU - Zare Javid, Ahmad
AU  - Zare Javid A
AUID- ORCID: 0000-0001-7119-7582
AD  - Nutrition and Metabolic Diseases Research Center, Clinical Sciences Research 
      Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
AD  - Department of Nutrition, School of Allied Medical Sciences, Ahvaz Jundishapur 
      University of Medical Sciences, Ahvaz, Iran.
LA  - eng
GR  - NRC-9911/Ahvaz Jundishapur University of Medical Sciences/
GR  - 99024630/Iran National Science Foundation/
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20220913
PL  - England
TA  - Phytother Res
JT  - Phytotherapy research : PTR
JID - 8904486
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Glycated Hemoglobin)
RN  - 0 (Flavonoids)
RN  - 5G06TVY3R7 (Rutin)
RN  - 0 (Cholesterol, LDL)
RN  - 0 (Interleukin-6)
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 0 (Antioxidants)
RN  - 0 (Triglycerides)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/drug therapy
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Glycated Hemoglobin
MH  - *Insulin Resistance/physiology
MH  - Flavonoids/pharmacology
MH  - Rutin/pharmacology/therapeutic use
MH  - Cholesterol, LDL
MH  - Interleukin-6/metabolism
MH  - Blood Glucose
MH  - Insulin
MH  - Antioxidants/pharmacology/therapeutic use/metabolism
MH  - Oxidative Stress
MH  - Triglycerides
MH  - Cholesterol
MH  - Double-Blind Method
OTO - NOTNLM
OT  - BDNF
OT  - inflammation
OT  - metabolic parameters
OT  - oxidative stress
OT  - rutin
OT  - type 2 diabetes mellitus
EDAT- 2022/09/15 06:00
MHDA- 2023/01/19 06:00
CRDT- 2022/09/14 03:02
PHST- 2022/07/06 00:00 [revised]
PHST- 2022/03/19 00:00 [received]
PHST- 2022/08/20 00:00 [accepted]
PHST- 2022/09/15 06:00 [pubmed]
PHST- 2023/01/19 06:00 [medline]
PHST- 2022/09/14 03:02 [entrez]
AID - 10.1002/ptr.7611 [doi]
PST - ppublish
SO  - Phytother Res. 2023 Jan;37(1):271-284. doi: 10.1002/ptr.7611. Epub 2022 Sep 13.