PMID- 36102230
OWN - NLM
STAT- MEDLINE
DCOM- 20221220
LR  - 20230124
IS  - 2057-4347 (Electronic)
IS  - 2057-4347 (Linking)
VI  - 8
IP  - 6
DP  - 2022 Dec
TI  - Comparative evaluation of intermediate solutions in prevention of brown 
      precipitate formed from sodium hypochlorite and chlorhexidine gluconate.
PG  - 1591-1597
LID - 10.1002/cre2.654 [doi]
AB  - OBJECTIVES: To evaluate intermediate treatments between sodium hypochlorite and 
      chlorhexidine gluconate irrigations for the prevention of a toxic brown 
      precipitate in root canal therapy. MATERIALS AND METHODS: Thirty-nine premolars 
      were irrigated with 6% sodium hypochlorite and divided into either: No 
      intermediate treatment; Dry paper points; three different irrigations with 17% 
      ethylenediaminetetraacetic acid, deionized water, or 5% sodium thiosulfate. 2% 
      chlorhexidine gluconate was the final irrigant in all groups. Sectioned teeth 
      were analyzed for brown precipitate intensity and area using stereomicroscopy and 
      components related to para-chloroaniline using Time-of-Flight Secondary Ion Mass 
      Spectrometry (ToF-SIMS). RESULTS: Stereomicroscopy showed that 5% STS 
      significantly reduced brown precipitate intensity and area as compared with no 
      intermediate irrigation (p < .05, Chi-square, generalized linear model, and 
      Tukey's multiple comparison tests). Utilizing ToF-SIMS, 5% sodium thiosulfate was 
      most effective in reducing the components representing para-chloroaniline and 
      chlorhexidine gluconate. CONCLUSION: The 5% sodium thiosulfate was most effective 
      among other intermediate treatments, assessed by stereomicroscopy and ToF-SIMS.
CI  - (c) 2022 The Authors. Clinical and Experimental Dental Research published by John 
      Wiley & Sons Ltd.
FAU - Bueso, Vashti
AU  - Bueso V
AD  - School of Dentistry, The University of Texas Health Science Center at Houston, 
      Houston, Texas, USA.
FAU - Parikh, Neha
AU  - Parikh N
AD  - Department of Diagnostic and Biomedical Sciences, The University of Texas Health 
      Science Center at Houston, School of Dentistry, Houston, Texas, USA.
FAU - Terlier, Tanguy
AU  - Terlier T
AD  - SIMS Laboratory, Shared Equipment Authority, Rice University, Houston, Texas, 
      USA.
FAU - Holland, Julian N
AU  - Holland JN
AD  - Office of Research, The University of Texas Health Science Center at Houston, 
      School of Dentistry, Houston, Texas, USA.
FAU - Sarmast, Nima D
AU  - Sarmast ND
AD  - Department of Endodontics, The University of Texas Health Science Center at 
      Houston, School of Dentistry, Houston, Texas, USA.
FAU - Jeong, Ji Wook
AU  - Jeong JW
AUID- ORCID: 0000-0003-1456-0730
AD  - Department of Endodontics, The University of Texas Health Science Center at 
      Houston, School of Dentistry, Houston, Texas, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20220914
PL  - United States
TA  - Clin Exp Dent Res
JT  - Clinical and experimental dental research
JID - 101692332
RN  - DY38VHM5OD (Sodium Hypochlorite)
RN  - MOR84MUD8E (chlorhexidine gluconate)
RN  - Z553SGH315 (4-chloroaniline)
RN  - HX1032V43M (sodium thiosulfate)
RN  - 0 (Root Canal Irrigants)
SB  - IM
MH  - *Sodium Hypochlorite
MH  - *Root Canal Irrigants
MH  - Chemical Precipitation
PMC - PMC9760148
OTO - NOTNLM
OT  - brown precipitation
OT  - chlorohexidine gluconate
OT  - intermediate irrigation
OT  - sodium hypochlorite
OT  - sodium thiosulphate
COIS- The authors declare no conflicts of interest.
EDAT- 2022/09/15 06:00
MHDA- 2022/12/21 06:00
PMCR- 2022/09/14
CRDT- 2022/09/14 05:43
PHST- 2022/08/11 00:00 [revised]
PHST- 2022/06/27 00:00 [received]
PHST- 2022/08/18 00:00 [accepted]
PHST- 2022/09/15 06:00 [pubmed]
PHST- 2022/12/21 06:00 [medline]
PHST- 2022/09/14 05:43 [entrez]
PHST- 2022/09/14 00:00 [pmc-release]
AID - CRE2654 [pii]
AID - 10.1002/cre2.654 [doi]
PST - ppublish
SO  - Clin Exp Dent Res. 2022 Dec;8(6):1591-1597. doi: 10.1002/cre2.654. Epub 2022 Sep 
      14.