PMID- 3610351
OWN - NLM
STAT- MEDLINE
DCOM- 19870915
LR  - 20190816
IS  - 0020-5915 (Print)
IS  - 0020-5915 (Linking)
VI  - 83
IP  - 4
DP  - 1987
TI  - Effect of cocaine on the immune response and host resistance in BALB/c mice.
PG  - 377-83
AB  - This study focuses on the effect of varying regimens of cocaine administration on 
      three parameters of the immune response: antibody production, resistance to 
      infection by Streptococcus pneumoniae following immunization, and resistance to 
      tumors. The effect of cocaine on antibody production of female and male BALB/c 
      mice was investigated to both a T-independent (pneumococcal polysaccharide type 
      III [SSS-III]) and a T-dependent antigen (the 2,4-dinitrophenyl ligand [DNP]). It 
      was found that high doses of cocaine injected 3 times/day prior to SSS-III 
      resulted in a small rise in antibody levels in male mice. Low doses given for 4 
      days prior to or subsequent to SSS-III injection had no effect on the antibody 
      response nor on the susceptibility to infection by live S. pneumoniae. High 
      dosages of cocaine administered 3-5 times/day had no effect on the anti-DNP 
      immune response of male mice but resulted in an almost 2-fold increase of 
      anti-DNP plaque-forming cells in female mice.
FAU - Havas, H F
AU  - Havas HF
FAU - Dellaria, M
AU  - Dellaria M
FAU - Schiffman, G
AU  - Schiffman G
FAU - Geller, E B
AU  - Geller EB
FAU - Adler, M W
AU  - Adler MW
LA  - eng
GR  - DA 00376/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Switzerland
TA  - Int Arch Allergy Appl Immunol
JT  - International archives of allergy and applied immunology
JID - 0404561
RN  - 0 (Dinitrobenzenes)
RN  - I5Y540LHVR (Cocaine)
SB  - IM
MH  - Animals
MH  - Antibody Formation/*drug effects
MH  - Cocaine/administration & dosage/*pharmacology/toxicity
MH  - Dinitrobenzenes/immunology
MH  - Female
MH  - Immunity, Cellular/*drug effects
MH  - Immunity, Innate/*drug effects
MH  - Injections, Intraperitoneal
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C/immunology
MH  - Neoplasms, Experimental/immunology/pathology
MH  - Pneumococcal Infections/prevention & control
MH  - Sex Factors
EDAT- 1987/01/01 00:00
MHDA- 1987/01/01 00:01
CRDT- 1987/01/01 00:00
PHST- 1987/01/01 00:00 [pubmed]
PHST- 1987/01/01 00:01 [medline]
PHST- 1987/01/01 00:00 [entrez]
AID - 10.1159/000234372 [doi]
PST - ppublish
SO  - Int Arch Allergy Appl Immunol. 1987;83(4):377-83. doi: 10.1159/000234372.