PMID- 36103839
OWN - NLM
STAT- MEDLINE
DCOM- 20221216
LR  - 20221222
IS  - 1423-0232 (Electronic)
IS  - 0030-2414 (Linking)
VI  - 100
IP  - 12
DP  - 2022
TI  - Revisiting the Evidence for Routine Transcervical Thymectomy for the Prevention 
      of Thymic Carcinoid Tumours in MEN-1 Patients.
PG  - 696-700
LID - 10.1159/000526775 [doi]
AB  - BACKGROUND: Malignant thymic carcinoids are uncommon tumours among patients with 
      multiple endocrine neoplasia type 1 (MEN-1). Current guidelines advise 
      performance of a preventative, routine transcervical thymectomy (TCT) during 
      parathyroidectomy, although data on the yield is scarce. In this review, we aimed 
      to revisit available literature to investigate and summarize the efficacy of 
      routine TCT for the prevention of thymic carcinoid tumours among MEN-1 patients 
      after searching four databases (PubMed, Embase, Medline, and Cochrane Library). 
      SUMMARY: Seven eligible studies were identified: retrospective observational 
      studies: 3 and case reports describing one or more patients: 4. A total of 122 
      patients were included, 56 males (45.9%) and a pooled mean age of 40 years (+/-10). 
      All underwent a routine TCT as part of parathyroidectomy; no details on the 
      extent of TCT were available. Overall, only one (0.9%) incidental carcinoid was 
      found. However, although all other patients underwent prophylactic TCT at the 
      time of parathyroidectomy, an additional nine (7.4%) developed a thymic carcinoid 
      during follow-up, after a median time of 36 months (range: 8-226). KEY MESSAGES: 
      There is currently not enough evidence to support the efficacy of a routine TCT 
      to prevent the development of thymic carcinoid among MEN-1 patients. As this is a 
      rare but potentially highly aggressive tumour, attention should be shifted 
      towards improving follow-up programs and developing specific imaging-screening 
      protocols. This enables early detection of thymic carcinoids in a timely manner 
      and improves outcomes, even after performance of a routine TCT.
CI  - (c) 2022 The Author(s). Published by S. Karger AG, Basel.
FAU - De Jong, Mechteld Christine
AU  - De Jong MC
AD  - Department of Endocrine Surgery, National University Hospital, Singapore, 
      Singapore.
FAU - Parameswaran, Rajeev
AU  - Parameswaran R
AD  - Department of Endocrine Surgery, National University Hospital, Singapore, 
      Singapore.
AD  - Department of Surgery, Yong Loo Lin School of Medicine, Singapore, Singapore.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220914
PL  - Switzerland
TA  - Oncology
JT  - Oncology
JID - 0135054
SB  - IM
MH  - Male
MH  - Humans
MH  - Adult
MH  - Thymectomy
MH  - *Multiple Endocrine Neoplasia Type 1/surgery/pathology
MH  - Retrospective Studies
MH  - *Thymus Neoplasms/surgery/pathology
MH  - *Carcinoid Tumor/surgery/diagnosis/pathology
OTO - NOTNLM
OT  - Carcinoid
OT  - Multiple endocrine neoplasia type 1
OT  - Parathyroidectomy
OT  - Thymus
EDAT- 2022/09/15 06:00
MHDA- 2022/12/17 06:00
CRDT- 2022/09/14 18:23
PHST- 2022/06/06 00:00 [received]
PHST- 2022/08/12 00:00 [accepted]
PHST- 2022/09/15 06:00 [pubmed]
PHST- 2022/12/17 06:00 [medline]
PHST- 2022/09/14 18:23 [entrez]
AID - 000526775 [pii]
AID - 10.1159/000526775 [doi]
PST - ppublish
SO  - Oncology. 2022;100(12):696-700. doi: 10.1159/000526775. Epub 2022 Sep 14.