PMID- 36105010
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220917
IS  - 1943-8141 (Print)
IS  - 1943-8141 (Electronic)
IS  - 1943-8141 (Linking)
VI  - 14
IP  - 8
DP  - 2022
TI  - Higher benefit-risk ratio of COVID-19 vaccination in patients with schizophrenia 
      and major depressive disorder versus patients with bipolar disorder when compared 
      to controls.
PG  - 5719-5729
AB  - Patients with major psychiatric disorders (MPD) that include schizophrenia (SCH), 
      bipolar disorder (BP), and major depressive disorder (MDD) are at increased risk 
      for coronavirus disease 2019 (COVID-19). However, the safety and efficacy of 
      COVID-19 vaccines in MPD patients have not been fully evaluated. This study aimed 
      to investigate adverse events (AEs)/side effects and efficacy of COVID-19 
      vaccines in MPD patients. This retrospective study included 2034 patients with 
      SCH, BP, or MDD who voluntarily received either BBIBP-CorV or Sinovac COVID-19 
      vaccines, and 2034 matched healthy controls. The incidence of AEs/side effects 
      and the efficacy of COIVD-19 vaccinations among the two groups were compared. The 
      risk ratio (RR) of side effects in patients with MPD was 0.60 (95% confidence 
      interval [CI]: 0.53-0.68) after the first dose and 0.80 (95% CI: 0.65-0.99) 
      following the second dose, suggesting a significantly lower risk in the MPD group 
      versus healthy controls. The RRs of AEs did not differ between patients and 
      controls. Notably, fully vaccinated patients exhibited a decreased risk of 
      influenza with or without fever compared with controls (RR=0.38, 95% CI: 
      0.31-0.46; RR=0.23, 95% CI: 0.17-0.30; respectively). Further subgroup 
      comparisons revealed a significantly lower risk of influenza with fever in MDD 
      (RR=0.13, 95% CI: 0.08-0.21) and SCH (RR=0.24, 95% CI: 0.17-0.34) than BP 
      (RR=0.85, 95% CI: 0.69-1.06) compared to controls. We conclude that the 
      benefit-risk ratio of COVID-19 vaccination was more favorable in SCH or MDD 
      versus BP when compared with controls. These data indicate that COVID-19 vaccines 
      are safe and protective in patients with MPD from COVID-19.
CI  - AJTR Copyright (c) 2022.
FAU - Zhu, Jingjing
AU  - Zhu J
AD  - Department of Psychiatry, Wenzhou Seventh People's Hospital Wenzhou 325000, 
      Zhejiang, China.
FAU - Tian, Hongjun
AU  - Tian H
AD  - Department of Psychiatry, Tianjin Fourth Center Hospital, Tianjin Fourth Center 
      Hospital Affiliated to Nankai University Tianjin 300222, China.
FAU - Wang, Haibo
AU  - Wang H
AD  - Peking University Clinical Research Institute, Peking University First Hospital 
      Beijing 100191, China.
FAU - Yu, Haiping
AU  - Yu H
AD  - Key Laboratory of Mental Disorder Associated Multiple Organ Damage (MDAMOD Lab), 
      Tianjin Fourth Center Hospital Tianjin 300140, China.
FAU - Liu, Chuanxin
AU  - Liu C
AD  - Institue of Psychiatry, Jining Medical University Jining 272119, China.
FAU - Wang, Lina
AU  - Wang L
AD  - Department of Psychiatry, Tianjin Fourth Center Hospital, Tianjin Fourth Center 
      Hospital Affiliated to Nankai University Tianjin 300222, China.
FAU - Li, Qianchen
AU  - Li Q
AD  - Peking University Clinical Research Institute, Peking University First Hospital 
      Beijing 100191, China.
FAU - Fang, Tao
AU  - Fang T
AD  - Key Laboratory of Mental Disorder Associated Multiple Organ Damage (MDAMOD Lab), 
      Tianjin Fourth Center Hospital Tianjin 300140, China.
FAU - Jia, Feng
AU  - Jia F
AD  - Peking University Clinical Research Institute, Peking University First Hospital 
      Beijing 100191, China.
FAU - Li, Yachen
AU  - Li Y
AD  - Peking University Clinical Research Institute, Peking University First Hospital 
      Beijing 100191, China.
FAU - Li, Ranli
AU  - Li R
AD  - Peking University Clinical Research Institute, Peking University First Hospital 
      Beijing 100191, China.
FAU - Ma, Xiaoyan
AU  - Ma X
AD  - Peking University Clinical Research Institute, Peking University First Hospital 
      Beijing 100191, China.
FAU - Sun, Yun
AU  - Sun Y
AD  - Peking University Clinical Research Institute, Peking University First Hospital 
      Beijing 100191, China.
FAU - Ping, Jing
AU  - Ping J
AD  - Peking University Clinical Research Institute, Peking University First Hospital 
      Beijing 100191, China.
FAU - Cai, Ziyao
AU  - Cai Z
AD  - Department of Psychiatry, Wenzhou Seventh People's Hospital Wenzhou 325000, 
      Zhejiang, China.
FAU - Jiang, Deguo
AU  - Jiang D
AD  - Department of Psychiatry, Wenzhou Seventh People's Hospital Wenzhou 325000, 
      Zhejiang, China.
FAU - Cheng, Langlang
AU  - Cheng L
AD  - Department of Psychiatry, Wenzhou Seventh People's Hospital Wenzhou 325000, 
      Zhejiang, China.
FAU - Chen, Min
AU  - Chen M
AD  - Institue of Psychiatry, Jining Medical University Jining 272119, China.
FAU - Liu, Sha
AU  - Liu S
AD  - MDT Center for Cognitive Impairment and Sleep Disorders, First Hospital/First 
      Clinical Medical College of Shanxi Medical University Taiyuan 030000, Shanxi, 
      China.
FAU - Xu, Yong
AU  - Xu Y
AD  - MDT Center for Cognitive Impairment and Sleep Disorders, First Hospital/First 
      Clinical Medical College of Shanxi Medical University Taiyuan 030000, Shanxi, 
      China.
FAU - Xu, Qingying
AU  - Xu Q
AD  - Department of Psychiatry, The First Affiliated Hospital of Harbin University 
      Harbin 150000, Heilongjiang, China.
FAU - Chen, Guangdong
AU  - Chen G
AD  - Department of Psychiatry, Wenzhou Seventh People's Hospital Wenzhou 325000, 
      Zhejiang, China.
FAU - Liu, Wei
AU  - Liu W
AD  - National Clinical Research Center for Mental Disorders & Key Laboratory of Mental 
      Health, Ministry of Health (Peking University), Peking University Sixth Hospital 
      (Institute of Mental Health) Beijing 100191, China.
FAU - Yue, Waihui
AU  - Yue W
AD  - Department of Psychiatry, The First Affiliated Hospital of Zhengzhou University 
      Zhengzhou 45000, Henan, China.
FAU - Song, Xueqin
AU  - Song X
AD  - Department of Psychiatry, Tianjin Anning Hospital Tianjin 300222, China.
FAU - Zhuo, Chuanjun
AU  - Zhuo C
AD  - Department of Psychiatry, Wenzhou Seventh People's Hospital Wenzhou 325000, 
      Zhejiang, China.
AD  - Department of Psychiatry, Tianjin Fourth Center Hospital, Tianjin Fourth Center 
      Hospital Affiliated to Nankai University Tianjin 300222, China.
AD  - Key Laboratory of Mental Disorder Associated Multiple Organ Damage (MDAMOD Lab), 
      Tianjin Fourth Center Hospital Tianjin 300140, China.
AD  - Department of Psychiatry, Tianjin Anning Hospital Tianjin 300222, China.
LA  - eng
PT  - Journal Article
DEP - 20220815
PL  - United States
TA  - Am J Transl Res
JT  - American journal of translational research
JID - 101493030
PMC - PMC9452368
OTO - NOTNLM
OT  - COVID-19 vaccine
OT  - SARS-CoV-2
OT  - bipolar disorder
OT  - effectiveness
OT  - major depressive disorder
OT  - safety
OT  - schizophrenia
COIS- None.
EDAT- 2022/09/16 06:00
MHDA- 2022/09/16 06:01
PMCR- 2022/08/15
CRDT- 2022/09/15 02:14
PHST- 2022/03/01 00:00 [received]
PHST- 2022/07/19 00:00 [accepted]
PHST- 2022/09/15 02:14 [entrez]
PHST- 2022/09/16 06:00 [pubmed]
PHST- 2022/09/16 06:01 [medline]
PHST- 2022/08/15 00:00 [pmc-release]
PST - epublish
SO  - Am J Transl Res. 2022 Aug 15;14(8):5719-5729. eCollection 2022.