PMID- 36105908
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220917
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 14
IP  - 9
DP  - 2022 Sep
TI  - Obesity, Diabetes Mellitus, and Vascular Impediment as Consequences of Excess 
      Processed Food Consumption.
PG  - e28762
LID - 10.7759/cureus.28762 [doi]
LID - e28762
AB  - Regular intake of ready-to-eat meals is related to obesity and several 
      noninfectious illnesses, such as cardiovascular diseases, hypertension, diabetes 
      mellitus (DM), and tumors. Processed foods contain high calories and are often 
      enhanced with excess refined sugar, saturated and trans fat, Na(+) 
      andphosphate-containing taste enhancers, and preservatives. Studies showed that 
      monosodium glutamate (MSG) induces raised echelons of oxidative stress, and 
      excessive hepatic lipogenesis is concomitant to obesity and type 2 diabetes 
      mellitus (T2DM). Likewise, more than standard salt intake adversely affects the 
      cardiovascular system, renal system, and central nervous system (CNS), especially 
      the brain. Globally, excessive utilization of phosphate-containing preservatives 
      and additives contributes unswervingly to excessive phosphate intake through 
      food. In addition, communities and even health experts, including medical 
      doctors, are not well-informed about the adverse effects of phosphate 
      preservatives on human health. Dietary phosphate excess often leads to phosphate 
      toxicity, ultimately potentiating kidney disease development. The mechanisms 
      involved in phosphate-related adverse effects are not explainable. Study reports 
      suggested that high blood level of phosphate causes vascular ossification through 
      the deposition of Ca(2+) and substantially alters fibroblast growth factor-23 
      (FGF23) and calcitriol.
CI  - Copyright (c) 2022, Sinha et al.
FAU - Sinha, Susmita
AU  - Sinha S
AD  - Physiology, Khulna City Medical College and Hospital, Khulna, BGD.
FAU - Haque, Mainul
AU  - Haque M
AD  - Pharmacology and Therapeutics, National Defence University of Malaysia, Kuala 
      Lumpur, MYS.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220904
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC9441778
OTO - NOTNLM
OT  - blood vessels
OT  - food additives
OT  - freshly
OT  - junk food
OT  - oven to table
OT  - phosphate
OT  - precooked food
OT  - prepackaged food
OT  - preservatives
OT  - unhealthy food
COIS- The authors have declared that no competing interests exist.
EDAT- 2022/09/16 06:00
MHDA- 2022/09/16 06:01
PMCR- 2022/09/04
CRDT- 2022/09/15 02:33
PHST- 2022/09/03 00:00 [accepted]
PHST- 2022/09/15 02:33 [entrez]
PHST- 2022/09/16 06:00 [pubmed]
PHST- 2022/09/16 06:01 [medline]
PHST- 2022/09/04 00:00 [pmc-release]
AID - 10.7759/cureus.28762 [doi]
PST - epublish
SO  - Cureus. 2022 Sep 4;14(9):e28762. doi: 10.7759/cureus.28762. eCollection 2022 Sep.