PMID- 36106494
OWN - NLM
STAT- MEDLINE
DCOM- 20221005
LR  - 20221005
IS  - 2042-650X (Electronic)
IS  - 2042-6496 (Linking)
VI  - 13
IP  - 19
DP  - 2022 Oct 3
TI  - Hypoglycemic effect of the polysaccharides from Astragalus membranaceus on type 2 
      diabetic mice based on the "gut microbiota-mucosal barrier".
PG  - 10121-10133
LID - 10.1039/d2fo02300h [doi]
AB  - Astragalus membranaceus polysaccharides (APP), the main active constituent, 
      possess numerous bioactivities. In this research, a type 2 diabetes mellitus 
      (T2DM) mouse model was combined with streptozotocin to study the hypoglycemic 
      effect and mechanism of APP. The results showed that APP improved glycolipid 
      metabolism disorders, inflammation and oxidative stress levels, and organ injury 
      in T2DM mice. Furthermore, the APP could protect the intestinal barrier by 
      suppressing intestinal inflammation and oxidative stress levels, and strongly 
      inhibited the potential intestinal pathogen Shigella with a reduction rate of 
      88.92%, and promoted the growth of beneficial bacteria Allobaculum and 
      Lactobacillus by 11.72% and 30.70%, respectively. In addition, the antibiotic 
      test indicated that the APP could repair intestinal barrier damage by remodeling 
      some specific gut microbiota which may be their hypoglycemic mechanism. The 
      results provide a theoretical basis for the development of APP as a novel 
      prebiotic in functional food for diabetes.
FAU - Chen, Xiaoxia
AU  - Chen X
AD  - SCUT-Zhuhai Institute of Modern Industrial Innovation, School of Food Science and 
      Engineering, South China University of Technology, 381 Wushan Road, Guangzhou 
      510640, China. chenc@scut.edu.cn.
FAU - Chen, Chun
AU  - Chen C
AUID- ORCID: 0000-0002-2178-1438
AD  - SCUT-Zhuhai Institute of Modern Industrial Innovation, School of Food Science and 
      Engineering, South China University of Technology, 381 Wushan Road, Guangzhou 
      510640, China. chenc@scut.edu.cn.
AD  - Guangzhou Institute of Modern Industrial Technology, Nansha, 511458, China.
AD  - Guangdong Province Key Laboratory for Green Processing of Natural Products and 
      Product Safety, Guangzhou 510640, China.
AD  - Overseas Expertise Introduction Center for Discipline Innovation of Food 
      Nutrition and Human Health (111 Center), Guangzhou 510640, China.
FAU - Fu, Xiong
AU  - Fu X
AD  - SCUT-Zhuhai Institute of Modern Industrial Innovation, School of Food Science and 
      Engineering, South China University of Technology, 381 Wushan Road, Guangzhou 
      510640, China. chenc@scut.edu.cn.
AD  - Guangzhou Institute of Modern Industrial Technology, Nansha, 511458, China.
AD  - Guangdong Province Key Laboratory for Green Processing of Natural Products and 
      Product Safety, Guangzhou 510640, China.
AD  - Overseas Expertise Introduction Center for Discipline Innovation of Food 
      Nutrition and Human Health (111 Center), Guangzhou 510640, China.
LA  - eng
PT  - Journal Article
DEP - 20221003
PL  - England
TA  - Food Funct
JT  - Food & function
JID - 101549033
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Glycolipids)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Polysaccharides)
RN  - 5W494URQ81 (Streptozocin)
SB  - IM
MH  - Animals
MH  - Anti-Bacterial Agents/pharmacology
MH  - Astragalus propinquus
MH  - *Diabetes Mellitus, Experimental/drug therapy
MH  - *Diabetes Mellitus, Type 2/drug therapy
MH  - *Gastrointestinal Microbiome
MH  - Glycolipids/pharmacology
MH  - Hypoglycemic Agents/pharmacology
MH  - Inflammation
MH  - Mice
MH  - Polysaccharides/pharmacology
MH  - Streptozocin
EDAT- 2022/09/16 06:00
MHDA- 2022/10/06 06:00
CRDT- 2022/09/15 04:32
PHST- 2022/09/16 06:00 [pubmed]
PHST- 2022/10/06 06:00 [medline]
PHST- 2022/09/15 04:32 [entrez]
AID - 10.1039/d2fo02300h [doi]
PST - epublish
SO  - Food Funct. 2022 Oct 3;13(19):10121-10133. doi: 10.1039/d2fo02300h.