PMID- 36106564
OWN - NLM
STAT- MEDLINE
DCOM- 20220916
LR  - 20221003
IS  - 1477-9129 (Electronic)
IS  - 0950-1991 (Linking)
VI  - 149
IP  - 18
DP  - 2022 Sep 15
TI  - Exploring the challenges and opportunities of public engagement with fundamental 
      biology.
LID - dev201170 [pii]
LID - 10.1242/dev.201170 [doi]
AB  - The Human Developmental Biology Initiative (HDBI) is a Wellcome-funded research 
      consortium involving scientists based in institutions across the UK and Europe. 
      It aims to pioneer new technologies and techniques to answer fundamental 
      questions about human development and could, therefore, eventually improve 
      treatments for fertility, birth defects and developmental diseases, as well as 
      aiding regenerative medicine. HDBI research relies on human fetal and embryonic 
      tissues donated following pregnancy terminations or fertility treatment. The 
      situations in which these tissues are donated, their use in research and the 
      potential healthcare impacts of this work all present complex ethical and moral 
      questions that are of interest not only to scientists but also to the public. As 
      such, HDBI's public engagement programme 'What makes us human?' aspires to test 
      new ways of engaging the public with fundamental biology. In this brief 
      Perspective, we provide an overview of this public engagement approach, exploring 
      its challenges and opportunities, and outline our longer-term plans. We hope that 
      by sharing our experiences we will encourage and enable others to organise 
      similarly experimental public engagement, even if their research is very 
      fundamental or potentially controversial.
CI  - (c) 2022. Published by The Company of Biologists Ltd.
FAU - Clements-Brod, Naomi
AU  - Clements-Brod N
AD  - Gurdon Institute and Department of Physiology, Development and Neuroscience, 
      University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK.
FAU - Holmes, Leah
AU  - Holmes L
AD  - Vocal, Manchester University NHS Foundation Trust, Nowgen Centre, 29 Grafton 
      Street, Manchester M13 9WU, UK.
FAU - Rawlins, Emma L
AU  - Rawlins EL
AUID- ORCID: 0000-0001-7426-3792
AD  - Gurdon Institute and Department of Physiology, Development and Neuroscience, 
      University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK.
LA  - eng
GR  - 215116/Z/18/C/WT_/Wellcome Trust/United Kingdom
GR  - MR/P009581/1/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220915
PL  - England
TA  - Development
JT  - Development (Cambridge, England)
JID - 8701744
SB  - IM
MH  - *Biology
MH  - Europe
MH  - Humans
COIS- Competing interests The authors declare no competing or financial interests.
EDAT- 2022/09/16 06:00
MHDA- 2022/09/17 06:00
CRDT- 2022/09/15 05:12
PHST- 2022/09/15 05:12 [entrez]
PHST- 2022/09/16 06:00 [pubmed]
PHST- 2022/09/17 06:00 [medline]
AID - 276538 [pii]
AID - 10.1242/dev.201170 [doi]
PST - ppublish
SO  - Development. 2022 Sep 15;149(18):dev201170. doi: 10.1242/dev.201170. Epub 2022 
      Sep 15.