PMID- 36107562
OWN - NLM
STAT- MEDLINE
DCOM- 20220919
LR  - 20220919
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 101
IP  - 35
DP  - 2022 Sep 2
TI  - Specific aeroallergen sensitization associated with current rhinitis among adults 
      in southwestern Saudi Arabia.
PG  - e30384
LID - 10.1097/MD.0000000000030384 [doi]
LID - e30384
AB  - Data about allergic sensitization to rhinitis among adults are limited. The 
      objectives were to explore the prevalence of current rhinitis (CR) and associated 
      specific allergen sensitizations in southwestern Saudi Arabia. A cross-sectional 
      study was conducted on 969 adults in southwestern regions of Saudi Arabia, namely 
      Aseer, Jazan, and Al Baha. From each region, 5 primary health care centers were 
      chosen. The validated Arabic Version of the International Study of Asthma and 
      Allergies in Childhood questionnaire was used. Total immunoglobulin E (IgE) 
      enzyme-linked immunosorbent assay, cytokine enzyme-linked immunosorbent assay 
      (interleukin [IL]-4, IL-10, IL-13, and interferon-gamma), aeroallergen-specific IgE 
      immunoassay (a panel of 30 common aeroallergens; 9 indoor and 21 outdoors), and 
      eosinophilic count were assessed. A prevalence of CR of 35.8% (95% confidence 
      interval: 32.8%-38.9%) was found. Regarding outdoor aeroallergens, 
      Mesquite-positive IgE antibodies were higher among CR adults (odds ratio = 1.52, 
      95% confidence interval: 1.02-2.21) compared to those without CR. The same 
      significant pattern was found with Chenopodium, Ragweed, Pigweed, Russian 
      thistle, Bermuda grass, Timothy grass, and Rye. All indoor aeroallergens were not 
      significantly associated with CR. Total IgE and eosinophil count were 
      significantly higher among adults with CR. In conclusion, CR in southwestern 
      regions of Saudi Arabia is common and of significant public health importance. 
      Aeroallergens that associate with adult sensitization to CR tend to be of the 
      outdoor variety particularly the herbaceous grass and their pollens. The 
      magnitude of CR and its association with exposure to outdoor aeroallergens should 
      be taken into account by health policy decision makers, clinicians, and medical 
      practitioners when diagnosing and treating related conditions.
CI  - Copyright (c) 2022 the Author(s). Published by Wolters Kluwer Health, Inc.
FAU - Al-Ghamdi, Badr Rashed
AU  - Al-Ghamdi BR
AD  - Department of Internal Medicine, College of Medicine, King Khalid University, 
      Abha, Saudi Arabia.
FAU - Omer, Fakhreldin Mohamed
AU  - Omer FM
AD  - Department of Clinical Microbiology, College of Medicine, King Khalid University, 
      Abha, Saudi Arabia.
FAU - Awadalla, Nabil J
AU  - Awadalla NJ
AD  - Department of Family and Community Medicine, College of Medicine, King Khalid 
      University, Abha, Saudi Arabia.
FAU - Mahfouz, Ahmed A
AU  - Mahfouz AA
AUID- ORCID: 0000-0002-4974-64310000-0002-4974-6431
AD  - Department of Family and Community Medicine, College of Medicine, King Khalid 
      University, Abha, Saudi Arabia.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Allergens)
RN  - 0 (Interleukin-13)
RN  - 130068-27-8 (Interleukin-10)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Adult
MH  - Allergens
MH  - Cross-Sectional Studies
MH  - Humans
MH  - Immunoglobulin E
MH  - Interferon-gamma
MH  - Interleukin-10
MH  - Interleukin-13
MH  - *Rhinitis
MH  - Saudi Arabia/epidemiology
PMC - PMC9439808
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2022/09/16 06:00
MHDA- 2022/09/20 06:00
PMCR- 2022/09/02
CRDT- 2022/09/15 11:55
PHST- 2022/09/15 11:55 [entrez]
PHST- 2022/09/16 06:00 [pubmed]
PHST- 2022/09/20 06:00 [medline]
PHST- 2022/09/02 00:00 [pmc-release]
AID - 00005792-202209020-00006 [pii]
AID - 10.1097/MD.0000000000030384 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2022 Sep 2;101(35):e30384. doi: 
      10.1097/MD.0000000000030384.