PMID- 36108461
OWN - NLM
STAT- MEDLINE
DCOM- 20221011
LR  - 20221011
IS  - 1878-3252 (Electronic)
IS  - 0946-672X (Linking)
VI  - 74
DP  - 2022 Dec
TI  - Associations of nickel exposure and kidney function in U.S. adults, NHANES 
      2017-2018.
PG  - 127065
LID - S0946-672X(22)00145-6 [pii]
LID - 10.1016/j.jtemb.2022.127065 [doi]
AB  - BACKGROUNDS: Nickel (Ni) is a ubiquitous heavy metal, but epidemiological studies 
      on the association between Ni and kidney function are limited and controversial. 
      AIM: We aimed to explore the relationship between urinary Ni concentrations and 
      kidney function in U.S. adults. METHODS: This was a cross-sectional study based 
      on the 2017-2018 National Health and Nutrition Examination Survey (NHANES) 
      (n = 1588). Multiple linear regression models, logistic regression models, and 
      restricted cubic spline models (RCS) were fitted to explore the associations 
      between urinary Ni and estimated glomerular filtration rate (eGFR), urinary 
      albumin-creatinine ratio (UACR), and the odds of impaired kidney function, which 
      was defined as an eGFR </= 60 mL/min per 1.73 m(2), or UACR >/= 30.0 mg/g. Bayesian 
      kernel machine regression (BKMR) was used to account for joint-metal effects. 
      RESULTS: Compared with the lowest quartile, urinary Ni at the third quartile was 
      associated with increased eGFR (beta = 2.42, 95 % CI: 0.23-4.19); the highest 
      quartile of urinary Ni was correlated with increased UACR (beta = 0.10, 95 % CI: 
      0.02-0.18), as well as higher odds of impaired kidney function (OR=1.65, 95 % 
      CI:1.08-2.54). Urinary Ni had a nonlinear inverted U-shape relationship with eGFR 
      (P(nonlinear) = 0.007), and linear J-shape associations with UACR (P(nonlinear) = 
      0.063) and impaired kidney function (P(nonlinear)= 0.215). Metal interaction of 
      urinary Ni with cadmium (Cd) on eGFR was observed. CONCLUSIONS: Our findings 
      provided evidence that Ni exposure linked with declined kidney function and might 
      interact with Cd exposure. Considering the cross-sectional design of the NHANES 
      study, further prospective studies are necessary.
CI  - Copyright (c) 2022 Elsevier GmbH. All rights reserved.
FAU - Nan, Yaxing
AU  - Nan Y
AD  - College of Earth and Environmental Sciences, Lanzhou University, Lanzhou 730000, 
      China; Gansu University of Chinese Medicine, Lanzhou 730000, China.
FAU - Yang, Jingli
AU  - Yang J
AD  - College of Earth and Environmental Sciences, Lanzhou University, Lanzhou 730000, 
      China.
FAU - Ma, Li
AU  - Ma L
AD  - Department of Epidemiology and Statistics, School of Public Health, Lanzhou 
      University, Lanzhou 730000, China.
FAU - Jin, Limei
AU  - Jin L
AD  - College of Earth and Environmental Sciences, Lanzhou University, Lanzhou 730000, 
      China; Gansu University of Chinese Medicine, Lanzhou 730000, China.
FAU - Bai, Yana
AU  - Bai Y
AD  - College of Earth and Environmental Sciences, Lanzhou University, Lanzhou 730000, 
      China; Department of Epidemiology and Statistics, School of Public Health, 
      Lanzhou University, Lanzhou 730000, China. Electronic address: 
      baiyana@lzu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20220908
PL  - Germany
TA  - J Trace Elem Med Biol
JT  - Journal of trace elements in medicine and biology : organ of the Society for 
      Minerals and Trace Elements (GMS)
JID - 9508274
RN  - 0 (Albumins)
RN  - 0 (Metals, Heavy)
RN  - 00BH33GNGH (Cadmium)
RN  - 7OV03QG267 (Nickel)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Albumins
MH  - Bayes Theorem
MH  - *Cadmium/urine
MH  - Creatinine
MH  - Cross-Sectional Studies
MH  - Glomerular Filtration Rate
MH  - Kidney
MH  - *Metals, Heavy
MH  - Nickel
MH  - Nutrition Surveys
MH  - Prospective Studies
OTO - NOTNLM
OT  - Glomerular filtration rate (GFR)
OT  - Kidney function
OT  - Metals
OT  - Nickel
OT  - Urine albumin-to-creatinine ratio (UACR)
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2022/09/16 06:00
MHDA- 2022/10/12 06:00
CRDT- 2022/09/15 18:20
PHST- 2022/05/21 00:00 [received]
PHST- 2022/07/26 00:00 [revised]
PHST- 2022/09/05 00:00 [accepted]
PHST- 2022/09/16 06:00 [pubmed]
PHST- 2022/10/12 06:00 [medline]
PHST- 2022/09/15 18:20 [entrez]
AID - S0946-672X(22)00145-6 [pii]
AID - 10.1016/j.jtemb.2022.127065 [doi]
PST - ppublish
SO  - J Trace Elem Med Biol. 2022 Dec;74:127065. doi: 10.1016/j.jtemb.2022.127065. Epub 
      2022 Sep 8.