PMID- 36108904
OWN - NLM
STAT- MEDLINE
DCOM- 20230118
LR  - 20230330
IS  - 1778-7254 (Electronic)
IS  - 1297-319X (Linking)
VI  - 90
IP  - 1
DP  - 2023 Jan
TI  - Diagnostic utility of a second minor salivary gland biopsy in patients with 
      suspected Sjogren's syndrome: A retrospective cohort study.
PG  - 105459
LID - S1297-319X(22)00119-1 [pii]
LID - 10.1016/j.jbspin.2022.105459 [doi]
AB  - OBJECTIVE: To determine whether repeated minor salivary gland biopsy (MSGB) has a 
      clinical diagnostic utility in patients with suspicion of Sjogren's syndrome 
      (SS). METHODS: Clinical, biological, pathological data and physician's diagnosis 
      after each MSGB from patients with suspected primary or secondary SS who had 
      benefited from 2 MSGB at Brest University Hospital between January 1st, 1990 and 
      January 14th, 2015, were retrospectively collected. We compared the 
      characteristics of patients with and without first positive MSGB, concordance 
      between the MSGB, and analyzed the modifications of diagnosis after the second 
      MSGB. RESULTS: Ninety-three patients were included, first MSGB was positive for 
      23 and negative for 70. Patients with first positive MSGB had more often renal 
      involvement (P<0.05) and hypergammaglobulinemia (P=0.01), anti-SSA antibodies 
      (P<0.05) and positive second biopsy with focus score >/= 1 or Chisholm>2 (P<0.01). 
      The mean time between the 2 MSGB was 5.7+/-4.3 years. The concordance between the 
      results of the 2 biopsies was low (kappa = 0.34). MSGB influenced diagnostic's change 
      in 10 cases where the second MSGB was always guided by new specific clinical 
      manifestations. CONCLUSION: We observed a low concordance between 2 MSGB in 
      patients with suspected pSS in our study. Despite this variability, performing a 
      second MSGB changed the initial diagnosis in only a minority of the patients and 
      was particularly useful when clinical manifestations had deeply evolved.
CI  - Copyright (c) 2022 Societe francaise de rhumatologie. Published by Elsevier Masson 
      SAS. All rights reserved.
FAU - Carvajal Alegria, Guillermo
AU  - Carvajal Alegria G
AD  - Rheumatology Department, CHRU de Brest, site Cavale Blanche, Brest, France; 
      Inserm, LabEx IGO, UMR1227, Lymphocytes B et Autoimmunite, Universite de Bretagne 
      Occidentale, Brest, France.
FAU - Depinoy, Thibaud
AU  - Depinoy T
AD  - Rheumatology Department, CHRU de Brest, site Cavale Blanche, Brest, France.
FAU - Devauchelle-Pensec, Valerie
AU  - Devauchelle-Pensec V
AD  - Rheumatology Department, CHRU de Brest, site Cavale Blanche, Brest, France; 
      Inserm, LabEx IGO, UMR1227, Lymphocytes B et Autoimmunite, Universite de Bretagne 
      Occidentale, Brest, France.
FAU - Jousse-Joulin, Sandrine
AU  - Jousse-Joulin S
AD  - Rheumatology Department, CHRU de Brest, site Cavale Blanche, Brest, France; 
      Inserm, LabEx IGO, UMR1227, Lymphocytes B et Autoimmunite, Universite de Bretagne 
      Occidentale, Brest, France.
FAU - Marhadour, Thierry
AU  - Marhadour T
AD  - Rheumatology Department, CHRU de Brest, site Cavale Blanche, Brest, France.
FAU - Guellec, Dewi
AU  - Guellec D
AD  - Rheumatology Department, CHRU de Brest, site Cavale Blanche, Brest, France; CIC 
      Inserm 1412, CHRU de Brest, Brest, France.
FAU - Marcorelles, Pascale
AU  - Marcorelles P
AD  - Pathology Department, CHRU de Brest, site Morvan, Brest, France.
FAU - Pers, Jacques-Olivier
AU  - Pers JO
AD  - Inserm, LabEx IGO, UMR1227, Lymphocytes B et Autoimmunite, Universite de Bretagne 
      Occidentale, Brest, France.
FAU - Saraux, Alain
AU  - Saraux A
AD  - Rheumatology Department, CHRU de Brest, site Cavale Blanche, Brest, France; 
      Inserm, LabEx IGO, UMR1227, Lymphocytes B et Autoimmunite, Universite de Bretagne 
      Occidentale, Brest, France.
FAU - Cornec, Divi
AU  - Cornec D
AD  - Rheumatology Department, CHRU de Brest, site Cavale Blanche, Brest, France; 
      Inserm, LabEx IGO, UMR1227, Lymphocytes B et Autoimmunite, Universite de Bretagne 
      Occidentale, Brest, France. Electronic address: divi.cornec@chu-brest.fr.
LA  - eng
PT  - Journal Article
DEP - 20220913
PL  - France
TA  - Joint Bone Spine
JT  - Joint bone spine
JID - 100938016
RN  - 89022-11-7 (2'-carbomethoxyphenyl 4-guanidinobenzoate)
SB  - IM
MH  - Humans
MH  - *Sjogren's Syndrome
MH  - Salivary Glands, Minor/pathology
MH  - Retrospective Studies
MH  - Biopsy
OTO - NOTNLM
OT  - Diagnosis
OT  - Minor salivary gland biopsy
OT  - Sjogren's syndrome
EDAT- 2022/09/16 06:00
MHDA- 2023/01/19 06:00
CRDT- 2022/09/15 19:26
PHST- 2022/04/20 00:00 [received]
PHST- 2022/07/29 00:00 [revised]
PHST- 2022/09/07 00:00 [accepted]
PHST- 2022/09/16 06:00 [pubmed]
PHST- 2023/01/19 06:00 [medline]
PHST- 2022/09/15 19:26 [entrez]
AID - S1297-319X(22)00119-1 [pii]
AID - 10.1016/j.jbspin.2022.105459 [doi]
PST - ppublish
SO  - Joint Bone Spine. 2023 Jan;90(1):105459. doi: 10.1016/j.jbspin.2022.105459. Epub 
      2022 Sep 13.