PMID- 36108945
OWN - NLM
STAT- MEDLINE
DCOM- 20231023
LR  - 20231023
IS  - 1567-7257 (Electronic)
IS  - 1567-1348 (Linking)
VI  - 105
DP  - 2022 Nov
TI  - Identification of human leukocyte antigen in precancerous and cancerous cervical 
      lesions from Ecuadorian women.
PG  - 105365
LID - S1567-1348(22)00162-9 [pii]
LID - 10.1016/j.meegid.2022.105365 [doi]
AB  - Cervical cancer is the fourth most common type of cancer in women. Worldwide, it 
      is a public health problem with around 604,127 women diagnosed per year and 
      341,831 deaths. Cervical cancer and persistent high-risk human papillomavirus 
      (HPV) infection are highly associated. However, other factors are also involved, 
      such as viral load, HPV variants, sexual behavior, and genetic factors. The host 
      immune response against HPV has been widely studied and it has shown associations 
      with development of cervical cancer. The human leukocyte antigen (HLA) genes are 
      related to the persistence of HPV infection and progression to cervical cancer 
      because of their role in controlling T-cell mediated immune response to clear the 
      infection. In Ecuador, there is scarce information about HLA and HPV infection 
      with high-risk genotypes in the population. This study aimed to identify 
      host-specific HLA alleles in women with cervical intraepithelial neoplasia (CIN) 
      II and III, and cancer infected with HPV-16, 58, and 52. In this study, we 
      included 51 samples previously identified as positive for HPV-16, 58, and 52 from 
      12 Ecuadorian provinces. As a result, we found that HLA-A*02, HLA-B*35, HLA-C*04, 
      HLA-DRB1*04, and HLA-DQB1*03 alleles were the most frequent, these alleles have 
      been associated with cervical cancer in previous studies; nevertheless, we did 
      not find a statistically significant association between HLA alleles, HPV 
      genotype, and histopathological lesion. This is a baseline study to uncover 
      possible relationships between HLA and HPV to elucidate why this virus can 
      develop a persistent infection in some women leading to the development of 
      cervical cancer.
CI  - Copyright (c) 2022 The Authors. Published by Elsevier B.V. All rights reserved.
FAU - Mora, Maria Jose
AU  - Mora MJ
AD  - Instituto de Microbiologia, Colegio de Ciencias Biologicas y Ambientales, 
      Universidad San Francisco de Quito USFQ, Quito, Ecuador.
FAU - de Los Angeles Bayas-Rea, Rosa
AU  - de Los Angeles Bayas-Rea R
AD  - Instituto de Microbiologia, Colegio de Ciencias Biologicas y Ambientales, 
      Universidad San Francisco de Quito USFQ, Quito, Ecuador.
FAU - Mejia, Lorena
AU  - Mejia L
AD  - Instituto de Microbiologia, Colegio de Ciencias Biologicas y Ambientales, 
      Universidad San Francisco de Quito USFQ, Quito, Ecuador.
FAU - Cruz, Cecilia
AU  - Cruz C
AD  - Hospital Carlos Andrade Marin, Ecuador.
FAU - Guerra, Sara
AU  - Guerra S
AD  - Hospital Carlos Andrade Marin, Ecuador.
FAU - Calle, Pamela
AU  - Calle P
AD  - Hospital Carlos Andrade Marin, Ecuador.
FAU - Sandoval, Diana Munoz
AU  - Sandoval DM
AD  - Instituto de Microbiologia, Colegio de Ciencias Biologicas y Ambientales, 
      Universidad San Francisco de Quito USFQ, Quito, Ecuador; Department of Infectious 
      Disease, Imperial College London, London, UK.
FAU - Galarza, Juan Miguel
AU  - Galarza JM
AD  - GenomicsLab, Quito, Ecuador.
FAU - Zapata-Mena, Sonia
AU  - Zapata-Mena S
AD  - Instituto de Microbiologia, Colegio de Ciencias Biologicas y Ambientales, 
      Universidad San Francisco de Quito USFQ, Quito, Ecuador. Electronic address: 
      szapata@usfq.edu.ec.
LA  - eng
PT  - Journal Article
DEP - 20220912
PL  - Netherlands
TA  - Infect Genet Evol
JT  - Infection, genetics and evolution : journal of molecular epidemiology and 
      evolutionary genetics in infectious diseases
JID - 101084138
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Humans
MH  - Female
MH  - *Uterine Cervical Neoplasms
MH  - *Papillomavirus Infections
MH  - Ecuador/epidemiology
MH  - *Uterine Cervical Dysplasia/genetics
MH  - Histocompatibility Antigens Class I/genetics
MH  - HLA-DRB1 Chains
MH  - Papillomaviridae/genetics
OTO - NOTNLM
OT  - CIN
OT  - Cervical cancer
OT  - Ecuador
OT  - HLA
OT  - HPV
EDAT- 2022/09/16 06:00
MHDA- 2023/10/23 00:43
CRDT- 2022/09/15 19:27
PHST- 2022/05/12 00:00 [received]
PHST- 2022/09/02 00:00 [revised]
PHST- 2022/09/10 00:00 [accepted]
PHST- 2023/10/23 00:43 [medline]
PHST- 2022/09/16 06:00 [pubmed]
PHST- 2022/09/15 19:27 [entrez]
AID - S1567-1348(22)00162-9 [pii]
AID - 10.1016/j.meegid.2022.105365 [doi]
PST - ppublish
SO  - Infect Genet Evol. 2022 Nov;105:105365. doi: 10.1016/j.meegid.2022.105365. Epub 
      2022 Sep 12.