PMID- 36109431
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221212
IS  - 2193-8253 (Print)
IS  - 2193-6536 (Electronic)
IS  - 2193-6536 (Linking)
VI  - 11
IP  - 4
DP  - 2022 Dec
TI  - Brivaracetam as Early Add-On Treatment in Patients with Focal Seizures: A 
      Retrospective, Multicenter, Real-World Study.
PG  - 1789-1804
LID - 10.1007/s40120-022-00402-3 [doi]
AB  - INTRODUCTION: In randomized controlled trials, add-on brivaracetam (BRV) reduced 
      seizure frequency in patients with drug-resistant focal epilepsy. Most real-world 
      research on BRV has focused on refractory epilepsy. The aim of this analysis was 
      to assess the 12-month effectiveness and tolerability of adjunctive BRV when used 
      as early or late adjunctive treatment in patients included in the BRIVAracetam 
      add-on First Italian netwoRk Study (BRIVAFIRST). METHODS: BRIVAFIRST was a 
      12-month retrospective, multicenter study including adult patients prescribed 
      adjunctive BRV. Effectiveness outcomes included the rates of sustained seizure 
      response, sustained seizure freedom, and treatment discontinuation. Safety and 
      tolerability outcomes included the rate of treatment discontinuation due to 
      adverse events (AEs) and the incidence of AEs. Data were compared for patients 
      treated with add-on BRV after 1-2 (early add-on) and >/= 3 (late add-on) prior 
      antiseizure medications. RESULTS: A total of 1029 patients with focal epilepsy 
      were included in the study, of whom 176 (17.1%) received BRV as early add-on 
      treatment. The median daily dose of BRV at 12 months was 125 (100-200) mg in the 
      early add-on group and 200 (100-200) in the late add-on group (p < 0.001). 
      Sustained seizure response was reached by 97/161 (60.3%) of patients in the early 
      add-on group and 286/833 (34.3%) of patients in the late add-on group 
      (p < 0.001). Sustained seizure freedom was achieved by 51/161 (31.7%) of patients 
      in the early add-on group and 91/833 (10.9%) of patients in the late add-on group 
      (p < 0.001). During the 1-year study period, 29 (16.5%) patients in the early 
      add-on group and 241 (28.3%) in the late add-on group discontinued BRV 
      (p = 0.001). Adverse events were reported by 38.7% and 28.5% (p = 0.017) of 
      patients who received BRV as early and late add-on treatment, respectively. 
      CONCLUSION: Brivaracetam was effective and well tolerated both as first add-on 
      and late adjunctive treatment in patients with focal epilepsy.
CI  - (c) 2022. The Author(s).
FAU - Lattanzi, Simona
AU  - Lattanzi S
AUID- ORCID: 0000-0001-8748-0083
AD  - Department of Experimental and Clinical Medicine, Neurological Clinic, Marche 
      Polytechnic University, Via Conca 71, 60020, Ancona, Italy. 
      alfierelattanzisimona@gmail.com.
FAU - Canafoglia, Laura
AU  - Canafoglia L
AD  - Department of Epileptology, Fondazione IRCCS Istituto Neurologico Carlo Besta, 
      Milan, Italy.
FAU - Canevini, Maria Paola
AU  - Canevini MP
AD  - Child Neuropsychiatry Unit, Epilepsy Center, AAST Santi Paolo Carlo, Milan, 
      Italy.
AD  - Department of Health Sciences, Universita degli Studi, Milan, Italy.
FAU - Casciato, Sara
AU  - Casciato S
AD  - IRCCS Neuromed, Pozzilli, Italy.
FAU - Cerulli Irelli, Emanuele
AU  - Cerulli Irelli E
AD  - Department of Human Neurosciences, Policlinico Umberto I, Sapienza University of 
      Rome, Rome, Italy.
FAU - Chiesa, Valentina
AU  - Chiesa V
AD  - Child Neuropsychiatry Unit, Epilepsy Center, AAST Santi Paolo Carlo, Milan, 
      Italy.
FAU - Dainese, Filippo
AU  - Dainese F
AD  - Neurology Unit, Epilepsy Centre, Venice, Italy.
FAU - De Maria, Giovanni
AU  - De Maria G
AD  - Clinical Neurophysiology Unit, Epilepsy Center, Spedali Civili, Brescia, Italy.
FAU - Didato, Giuseppe
AU  - Didato G
AD  - Epilepsy Unit, Fondazione IRCCS Istituto Neurologico "Carlo Besta", Milan, Italy.
FAU - Di Gennaro, Giancarlo
AU  - Di Gennaro G
AD  - IRCCS Neuromed, Pozzilli, Italy.
FAU - Falcicchio, Giovanni
AU  - Falcicchio G
AD  - Department of Basic Medical Sciences, Neurosciences and Sense Organs, University 
      Hospital of Bari "A. Moro", Bari, Italy.
FAU - Fanella, Martina
AU  - Fanella M
AD  - Department of Human Neurosciences, Policlinico Umberto I, Sapienza University of 
      Rome, Rome, Italy.
FAU - Ferlazzo, Edoardo
AU  - Ferlazzo E
AD  - Department of Medical and Surgical Sciences, Magna Graecia University of 
      Catanzaro, Catanzaro, Italy.
FAU - Gangitano, Massimo
AU  - Gangitano M
AD  - Department of Biomedicine, Neuroscience, and Advanced Diagnostic (BIND), 
      University of Palermo, Palermo, Italy.
FAU - La Neve, Angela
AU  - La Neve A
AD  - Department of Basic Medical Sciences, Neurosciences and Sense Organs, University 
      Hospital of Bari "A. Moro", Bari, Italy.
FAU - Mecarelli, Oriano
AU  - Mecarelli O
AD  - Department of Human Neurosciences, Policlinico Umberto I, Sapienza University of 
      Rome, Rome, Italy.
FAU - Montalenti, Elisa
AU  - Montalenti E
AD  - Epilepsy Center, AOU Citta della Salute e della Scienza di Torino, Turin, Italy.
FAU - Morano, Alessandra
AU  - Morano A
AD  - Department of Human Neurosciences, Policlinico Umberto I, Sapienza University of 
      Rome, Rome, Italy.
FAU - Piazza, Federico
AU  - Piazza F
AD  - "Rita Levi Montalcini" Department of Neurosciences, University of Turin, Turin, 
      Italy.
FAU - Pizzanelli, Chiara
AU  - Pizzanelli C
AD  - Department of Translational Research on New Technologies in Medicine and Surgery, 
      University of Pisa, Pisa, Italy.
AD  - Neurology Unit, Pisa University Hospital, Pisa, Italy.
FAU - Pulitano, Patrizia
AU  - Pulitano P
AD  - Department of Human Neurosciences, Policlinico Umberto I, Sapienza University of 
      Rome, Rome, Italy.
FAU - Ranzato, Federica
AU  - Ranzato F
AD  - Epilepsy Center, UOC Neurology, AULSS 8 Vicenza, Vicenza, Italy.
FAU - Rosati, Eleonora
AU  - Rosati E
AD  - Department Neurology 2, Careggi University Hospital, Florence, Italy.
FAU - Tassi, Laura
AU  - Tassi L
AD  - "C. Munari" Epilepsy Surgery Centre, Niguarda Hospital, Milan, Italy.
FAU - Di Bonaventura, Carlo
AU  - Di Bonaventura C
AD  - Department of Human Neurosciences, Policlinico Umberto I, Sapienza University of 
      Rome, Rome, Italy.
CN  - BRIVAracetam add-on First Italian netwoRk Study (BRIVAFIRST) Group
LA  - eng
PT  - Journal Article
DEP - 20220916
PL  - New Zealand
TA  - Neurol Ther
JT  - Neurology and therapy
JID - 101637818
PMC - PMC9588144
OTO - NOTNLM
OT  - Antiseizure medication
OT  - Brivaracetam
OT  - Epilepsy
OT  - Focal seizures
FIR - Alicino, Angela
IR  - Alicino A
FIR - Ascoli, Michele
IR  - Ascoli M
FIR - Assenza, Giovanni
IR  - Assenza G
FIR - Avorio, Federica
IR  - Avorio F
FIR - Badioni, Valeria
IR  - Badioni V
FIR - Banfi, Paola
IR  - Banfi P
FIR - Bartolini, Emanuele
IR  - Bartolini E
FIR - Basili, Luca Manfredi
IR  - Basili LM
FIR - Belcastro, Vincenzo
IR  - Belcastro V
FIR - Beretta, Simone
IR  - Beretta S
FIR - Berto, Irene
IR  - Berto I
FIR - Biggi, Martina
IR  - Biggi M
FIR - Billo, Giuseppe
IR  - Billo G
FIR - Boero, Giovanni
IR  - Boero G
FIR - Bonanni, Paolo
IR  - Bonanni P
FIR - Bongorno, Jole
IR  - Bongorno J
FIR - Brigo, Francesco
IR  - Brigo F
FIR - Caggia, Emanuele
IR  - Caggia E
FIR - Cagnetti, Claudia
IR  - Cagnetti C
FIR - Calvello, Carmen
IR  - Calvello C
FIR - Cesnik, Edward
IR  - Cesnik E
FIR - Chianale, Gigliola
IR  - Chianale G
FIR - Ciampanelli, Domenico
IR  - Ciampanelli D
FIR - Ciuffini, Roberta
IR  - Ciuffini R
FIR - Cocito, Dario
IR  - Cocito D
FIR - Colella, Donato
IR  - Colella D
FIR - Contento, Margherita
IR  - Contento M
FIR - Costa, Cinzia
IR  - Costa C
FIR - Cumbo, Eduardo
IR  - Cumbo E
FIR - D'Aniello, Alfredo
IR  - D'Aniello A
FIR - Deleo, Francesco
IR  - Deleo F
FIR - DiFrancesco, Jacopo C
IR  - DiFrancesco JC
FIR - Di Giacomo, Roberta
IR  - Di Giacomo R
FIR - Di Liberto, Alessandra
IR  - Di Liberto A
FIR - Domina, Elisabetta
IR  - Domina E
FIR - Dono, Fedele
IR  - Dono F
FIR - Durante, Vania
IR  - Durante V
FIR - Elia, Maurizio
IR  - Elia M
FIR - Estraneo, Anna
IR  - Estraneo A
FIR - Evangelista, Giacomo
IR  - Evangelista G
FIR - Faedda, Maria Teresa
IR  - Faedda MT
FIR - Failli, Ylenia
IR  - Failli Y
FIR - Fallica, Elisa
IR  - Fallica E
FIR - Fattouch, Jinane
IR  - Fattouch J
FIR - Ferrari, Alessandra
IR  - Ferrari A
FIR - Ferreri, Florinda
IR  - Ferreri F
FIR - Fisco, Giacomo
IR  - Fisco G
FIR - Fonti, Davide
IR  - Fonti D
FIR - Fortunato, Francesco
IR  - Fortunato F
FIR - Foschi, Nicoletta
IR  - Foschi N
FIR - Francavilla, Teresa
IR  - Francavilla T
FIR - Galli, Rosita
IR  - Galli R
FIR - Gazzina, Stefano
IR  - Gazzina S
FIR - Giallonardo, Anna Teresa
IR  - Giallonardo AT
FIR - Giorgi, Filippo Sean
IR  - Giorgi FS
FIR - Giuliano, Loretta
IR  - Giuliano L
FIR - Habetswallner, Francesco
IR  - Habetswallner F
FIR - Izzi, Francesca
IR  - Izzi F
FIR - Kassabian, Benedetta
IR  - Kassabian B
FIR - Labate, Angelo
IR  - Labate A
FIR - Luisi, Concetta
IR  - Luisi C
FIR - Magliani, Matteo
IR  - Magliani M
FIR - Maira, Giulia
IR  - Maira G
FIR - Mari, Luisa
IR  - Mari L
FIR - Marino, Daniela
IR  - Marino D
FIR - Mascia, Addolorata
IR  - Mascia A
FIR - Mazzeo, Alessandra
IR  - Mazzeo A
FIR - Meletti, Stefano
IR  - Meletti S
FIR - Milano, Chiara
IR  - Milano C
FIR - Nilo, Annacarmen
IR  - Nilo A
FIR - Orlando, Biagio
IR  - Orlando B
FIR - Paladin, Francesco
IR  - Paladin F
FIR - Pascarella, Maria Grazia
IR  - Pascarella MG
FIR - Pastori, Chiara
IR  - Pastori C
FIR - Pauletto, Giada
IR  - Pauletto G
FIR - Peretti, Alessia
IR  - Peretti A
FIR - Perri, Gabriella
IR  - Perri G
FIR - Pezzella, Marianna
IR  - Pezzella M
FIR - Piccioli, Marta
IR  - Piccioli M
FIR - Pignatta, Pietro
IR  - Pignatta P
FIR - Pilolli, Nicola
IR  - Pilolli N
FIR - Pisani, Francesco
IR  - Pisani F
FIR - Pisani, Laura Rosa
IR  - Pisani LR
FIR - Placidi, Fabio
IR  - Placidi F
FIR - Pollicino, Patrizia
IR  - Pollicino P
FIR - Porcella, Vittoria
IR  - Porcella V
FIR - Pradella, Silvia
IR  - Pradella S
FIR - Puligheddu, Monica
IR  - Puligheddu M
FIR - Quadri, Stefano
IR  - Quadri S
FIR - Quarato, Pier Paolo
IR  - Quarato PP
FIR - Quintas, Rui
IR  - Quintas R
FIR - Renna, Rosaria
IR  - Renna R
FIR - Rizzo, Giada Ricciardo
IR  - Rizzo GR
FIR - Rum, Adriana
IR  - Rum A
FIR - Salamone, Enrico Michele
IR  - Salamone EM
FIR - Savastano, Ersilia
IR  - Savastano E
FIR - Sessa, Maria
IR  - Sessa M
FIR - Stokelj, David
IR  - Stokelj D
FIR - Tartara, Elena
IR  - Tartara E
FIR - Tombini, Mario
IR  - Tombini M
FIR - Tumminelli, Gemma
IR  - Tumminelli G
FIR - Vaudano, Anna Elisabetta
IR  - Vaudano AE
FIR - Ventura, Maria
IR  - Ventura M
FIR - Vigano, Ilaria
IR  - Vigano I
FIR - Viglietta, Emanuela
IR  - Viglietta E
FIR - Vignoli, Aglaia
IR  - Vignoli A
FIR - Villani, Flavio
IR  - Villani F
FIR - Zambrelli, Elena
IR  - Zambrelli E
FIR - Zummo, Lelia
IR  - Zummo L
EDAT- 2022/09/16 06:00
MHDA- 2022/09/16 06:01
PMCR- 2022/09/16
CRDT- 2022/09/15 23:15
PHST- 2022/07/21 00:00 [received]
PHST- 2022/08/24 00:00 [accepted]
PHST- 2022/09/16 06:00 [pubmed]
PHST- 2022/09/16 06:01 [medline]
PHST- 2022/09/15 23:15 [entrez]
PHST- 2022/09/16 00:00 [pmc-release]
AID - 10.1007/s40120-022-00402-3 [pii]
AID - 402 [pii]
AID - 10.1007/s40120-022-00402-3 [doi]
PST - ppublish
SO  - Neurol Ther. 2022 Dec;11(4):1789-1804. doi: 10.1007/s40120-022-00402-3. Epub 2022 
      Sep 16.