PMID- 36109703
OWN - NLM
STAT- MEDLINE
DCOM- 20220919
LR  - 20221207
IS  - 1472-6823 (Electronic)
IS  - 1472-6823 (Linking)
VI  - 22
IP  - 1
DP  - 2022 Sep 15
TI  - Visceral fat area and body fat percentage measured by bioelectrical impedance 
      analysis correlate with glycometabolism.
PG  - 231
LID - 10.1186/s12902-022-01142-z [doi]
LID - 231
AB  - BACKGROUND: Adiposity evaluated by body mass index (BMI) is associated with 
      glycometabolism. The aim of the investigation was to explore the correlation of 
      visceral fat area (VFA), body fat percentage (BFP), BMI and waist circumference 
      (WC) with type 2 diabetes mellitus (T2DM) and pre-diabetes. METHODS: A total of 
      18,458 participates underwent physical examination in Nanjing Drum Tower Hospital 
      from January 2018 to April 2022 was included in this study. Data were collected 
      retrospectively. Regression analysis was used to evaluate the relationship of 
      VFA, BFP, WC and BMI with diabetes status, fasting blood glucose (FBG) and 
      glycohemoglobin (HbA1c). RESULTS: After fully adjusted for multiple covariates, 
      VFA, BFP, WC and BMI in T2DM and pre-diabetes group exceeded compared with normal 
      group. FBG was positively correlated with VFA, BFP, WC and BMI with betas of 
      2.221,0.306,0.606 and 0.175(p < 0.001). HbA1c was also positively correlated with 
      the four indexes with betas of 2.645, 0.328, 0.685 and 0.255(p < 0.001). Subgroup 
      analysis shown that FBG and HbA1c were positively correlated with VFA, BFP, BMI 
      and WC in normal and pre-diabetes group (p < 0.001). FBG was negatively 
      correlated with BMI in T2DM group (p = 0.023). In T2DM, there were non-linear 
      relationships of HbA1c with VFA, BFP, WC and BMI with the inflection points for 
      about 7%. Before the inflection point, HbA1c was positively correlated with 
      obesity-related indicators, and it was reversed after the inflection point. In 
      the individuals with excessive VFA and normal BMI, the risk for glycometabolism 
      disorder exceed compared with normal VFA and normal BMI. Every per-standard 
      deviation increasing in VFA, BFP, WC and BMI, the corresponding risk increasing 
      of glycometabolism disorder was 16.4, 14.6, 22.6 and 22.2%. CONCLUSION: The study 
      demonstrated that in adults with T2DM or prediabetes, the VFA, BFP, WC and BMI 
      were higher than with normal glycometabolism. In pre-diabetes and normal 
      population, there were positive correlations of HbA1c and FBG with 
      obesity-related indicators. In T2DM with poor glycemic control (HbA1c > 7%), 
      there might be a trend of fat loss. VFA could negatively affect glycometabolism 
      independently from BMI. The optimum to evaluate the risk of glycometabolism 
      disorder was WC.
CI  - (c) 2022. The Author(s).
FAU - Li, Shuying
AU  - Li S
AD  - Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University 
      Medical School, Nanjing, China.
FAU - Li, Shaoping
AU  - Li S
AD  - Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University 
      Medical School, Nanjing, China.
FAU - Ding, Jie
AU  - Ding J
AD  - Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University 
      Medical School, Nanjing, China.
FAU - Zhou, Weihong
AU  - Zhou W
AD  - Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University 
      Medical School, Nanjing, China. njzhouwh@126.com.
LA  - eng
PT  - Journal Article
DEP - 20220915
PL  - England
TA  - BMC Endocr Disord
JT  - BMC endocrine disorders
JID - 101088676
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
SB  - IM
MH  - Adult
MH  - Blood Glucose
MH  - *Diabetes Mellitus, Type 2/diagnosis/epidemiology
MH  - Electric Impedance
MH  - Glycated Hemoglobin
MH  - Humans
MH  - Intra-Abdominal Fat
MH  - Obesity/diagnosis/epidemiology
MH  - *Prediabetic State/diagnosis/epidemiology
MH  - Retrospective Studies
MH  - Risk Factors
PMC - PMC9479287
OTO - NOTNLM
OT  - Bioelectrical impedance analysis
OT  - Body fat percentage
OT  - Pre-diabetes
OT  - T2DM
OT  - Visceral fat area
COIS- Authors declare that they have no conflicts of interest.
EDAT- 2022/09/16 06:00
MHDA- 2022/09/20 06:00
PMCR- 2022/09/15
CRDT- 2022/09/15 23:41
PHST- 2022/06/07 00:00 [received]
PHST- 2022/08/31 00:00 [accepted]
PHST- 2022/09/15 23:41 [entrez]
PHST- 2022/09/16 06:00 [pubmed]
PHST- 2022/09/20 06:00 [medline]
PHST- 2022/09/15 00:00 [pmc-release]
AID - 10.1186/s12902-022-01142-z [pii]
AID - 1142 [pii]
AID - 10.1186/s12902-022-01142-z [doi]
PST - epublish
SO  - BMC Endocr Disord. 2022 Sep 15;22(1):231. doi: 10.1186/s12902-022-01142-z.