PMID- 36110045
OWN - NLM
STAT- MEDLINE
DCOM- 20221207
LR  - 20221214
IS  - 1469-8137 (Electronic)
IS  - 0028-646X (Linking)
VI  - 237
IP  - 1
DP  - 2023 Jan
TI  - 14-3-3 proteins regulate photomorphogenesis by facilitating light-induced 
      degradation of PIF3.
PG  - 140-159
LID - 10.1111/nph.18494 [doi]
AB  - 14-3-3s are highly conserved phosphopeptide-binding proteins that play important 
      roles in various developmental and signaling pathways in plants. However, 
      although protein phosphorylation has been proven to be a key mechanism for 
      regulating many pivotal components of the light signaling pathway, the role of 
      14-3-3 proteins in photomorphogenesis remains largely obscure. 
      PHYTOCHROME-INTERACTING FACTOR3 (PIF3) is an extensively studied transcription 
      factor repressing photomorphogenesis, and it is well-established that upon red 
      (R) light exposure, photo-activated phytochrome B (phyB) interacts with PIF3 and 
      induces its rapid phosphorylation and degradation. PHOTOREGULATORY PROTEIN 
      KINASES (PPKs), a family of nuclear protein kinases, interact with phyB and PIF3 
      in R light and mediate multisite phosphorylation of PIF3 in vivo. Here, we report 
      that two members of the 14-3-3 protein family, 14-3-3lambda and kappa, bind to a serine 
      residue in the bHLH domain of PIF3 that can be phosphorylated by PPKs, and act as 
      key positive regulators of R light-induced photomorphogenesis. Moreover, 14-3-3lambda 
      and kappa preferentially interact with photo-activated phyB and promote the 
      phyB-PIF3-PPK complex formation, thereby facilitating phyB-induced 
      phosphorylation and degradation of PIF3 upon R light exposure. Together, our data 
      demonstrate that 14-3-3lambda and kappa work in close concert with the phyB-PIF3 module to 
      regulate light signaling in Arabidopsis.
CI  - (c) 2022 The Authors. New Phytologist (c) 2022 New Phytologist Foundation.
FAU - Song, Pengyu
AU  - Song P
AUID- ORCID: 0000-0002-9830-7013
AD  - State Key Laboratory of Plant Physiology and Biochemistry, College of Biological 
      Sciences, China Agricultural University, Beijing, 100193, China.
FAU - Yang, Zidan
AU  - Yang Z
AUID- ORCID: 0000-0002-3190-1288
AD  - State Key Laboratory of Plant Physiology and Biochemistry, College of Biological 
      Sciences, China Agricultural University, Beijing, 100193, China.
AD  - MOE Key Laboratory of Crop Heterosis and Utilization, College of Agronomy and 
      Biotechnology, China Agricultural University, Beijing, 100193, China.
FAU - Guo, Can
AU  - Guo C
AUID- ORCID: 0000-0002-7756-9559
AD  - State Key Laboratory of Plant Physiology and Biochemistry, College of Biological 
      Sciences, China Agricultural University, Beijing, 100193, China.
FAU - Han, Run
AU  - Han R
AUID- ORCID: 0000-0003-3053-3070
AD  - State Key Laboratory of Plant Physiology and Biochemistry, College of Biological 
      Sciences, China Agricultural University, Beijing, 100193, China.
FAU - Wang, Huaichang
AU  - Wang H
AUID- ORCID: 0000-0003-2200-3221
AD  - State Key Laboratory of Plant Physiology and Biochemistry, College of Biological 
      Sciences, China Agricultural University, Beijing, 100193, China.
FAU - Dong, Jie
AU  - Dong J
AUID- ORCID: 0000-0003-0493-1665
AD  - Institute of Crop Science, Zhejiang University, Hangzhou, 310058, China.
FAU - Kang, Dingming
AU  - Kang D
AUID- ORCID: 0000-0001-8103-877X
AD  - MOE Key Laboratory of Crop Heterosis and Utilization, College of Agronomy and 
      Biotechnology, China Agricultural University, Beijing, 100193, China.
FAU - Guo, Yan
AU  - Guo Y
AUID- ORCID: 0000-0001-9018-770X
AD  - State Key Laboratory of Plant Physiology and Biochemistry, College of Biological 
      Sciences, China Agricultural University, Beijing, 100193, China.
FAU - Yang, Shuhua
AU  - Yang S
AUID- ORCID: 0000-0003-1229-7166
AD  - State Key Laboratory of Plant Physiology and Biochemistry, College of Biological 
      Sciences, China Agricultural University, Beijing, 100193, China.
FAU - Li, Jigang
AU  - Li J
AUID- ORCID: 0000-0002-4395-2656
AD  - State Key Laboratory of Plant Physiology and Biochemistry, College of Biological 
      Sciences, China Agricultural University, Beijing, 100193, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220930
PL  - England
TA  - New Phytol
JT  - The New phytologist
JID - 9882884
RN  - 11121-56-5 (Phytochrome)
RN  - 0 (Arabidopsis Proteins)
RN  - 0 (14-3-3 Proteins)
RN  - 0 (Basic Helix-Loop-Helix Transcription Factors)
RN  - 136250-22-1 (Phytochrome B)
RN  - 0 (PIF3 protein, Arabidopsis)
SB  - IM
MH  - *Phytochrome/metabolism
MH  - *Arabidopsis Proteins/genetics/metabolism
MH  - 14-3-3 Proteins/metabolism
MH  - Basic Helix-Loop-Helix Transcription Factors/metabolism
MH  - Light
MH  - Phytochrome B/metabolism
MH  - *Arabidopsis/genetics/metabolism
OTO - NOTNLM
OT  - 14-3-3
OT  - Arabidopsis
OT  - PIF3
OT  - photomorphogenesis
OT  - phytochrome
EDAT- 2022/09/17 06:00
MHDA- 2022/12/15 06:00
CRDT- 2022/09/16 01:42
PHST- 2022/07/28 00:00 [received]
PHST- 2022/09/09 00:00 [accepted]
PHST- 2022/09/17 06:00 [pubmed]
PHST- 2022/12/15 06:00 [medline]
PHST- 2022/09/16 01:42 [entrez]
AID - 10.1111/nph.18494 [doi]
PST - ppublish
SO  - New Phytol. 2023 Jan;237(1):140-159. doi: 10.1111/nph.18494. Epub 2022 Sep 30.