PMID- 36110559
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220917
IS  - 1611-2156 (Print)
IS  - 1611-2156 (Electronic)
IS  - 1611-2156 (Linking)
VI  - 21
DP  - 2022
TI  - Ameliorative effects of high intensity interval training and Lactobacillus 
      rhamnosus GG Protect against tetracycline-induced fatty liver in rats: a gene 
      expression profiling comparative study.
PG  - 991-1006
LID - 10.17179/excli2022-4791 [doi]
AB  - Exercise training and probiotics have been suggested as a treatment for the 
      prevention of chronic liver damage such as non-alcoholic fatty liver disease 
      (NAFLD). Lactobacillus rhamnosus Gorbach - Goldin (LGG) is one of the most widely 
      used probiotic strains that decreases liver damage. Thus, this study aims to 
      consider the ameliorative effects of high intensity interval training (HIIT) and 
      LGG against tetracycline-induced fatty liver in rats. Eighty male Wistar rats 
      were randomly divided into 8 groups of (n=10 each group): control, LGG, HIIT, 
      LGG+HIIT, NAFLD, NAFLD+LGG, NAFLD+HIIT, and NAFLD+LGG+HIIT. The rats are treated 
      by intraperitoneal injection with 140 mg/kg(-1) tetracycline, an antibiotic 
      previously known to induce steatosis. The exercise training groups performed HIIT 
      5 days/week for 5 weeks. 10(7) colony-forming units (cfu) of LGG were gavaged for 
      LGG groups 5 days/week for 5 weeks. Probiotic supplementation in combination with 
      interval training significantly decreased tissue inhibitor of matrix 
      metalloproteinases-1 (TIMP-1) mRNA and matrix metalloproteinase-2 (MMP-2) mRNA in 
      the liver (p<0.05), while the levels of lysosomal acid lipase (LIPA) mRNA was 
      significantly increased compared to NAFLD group. Also, compared with NAFLD group, 
      NAFLD+LGG, NAFLD+HIIT and NAFLD+LGG+HIIT groups showed a significant decrease in 
      hepatic monocyte chemoattractant protein-1 (MCP-1). Compared to LGG and LGG+HIIT 
      groups, all NAFLD groups showed a significant decrease in apolipoprotein C3 
      (apoc3) in liver tissue (p<0.05). The results suggested that interval exercise 
      with LGG supplementation minimizes cell destruction and inflammation in liver 
      tissue due to NAFLD by improving gene expression profiles.
CI  - Copyright (c) 2022 Hosseini et al.
FAU - Hosseini, Hamideh Mahmoodzadeh
AU  - Hosseini HM
AD  - Applied Microbiology Research Center, Systems Biology and Poisonings Institute, 
      Baqiyatallah University of Medical Sciences, Tehran, Iran.
FAU - Shirvani, Hossein
AU  - Shirvani H
AD  - Exercise Physiology Research Center, Life Style Institute, Baqiyatallah 
      University of Medical Sciences, Tehran, Iran.
FAU - Aghaei, Fariba
AU  - Aghaei F
AD  - Faculty of Physical Education and Sport Sciences, Karaj Branch, Islamic Azad 
      University, Alborz, Iran.
FAU - Arabzadeh, Ehsan
AU  - Arabzadeh E
AD  - Exercise Physiology Research Center, Life Style Institute, Baqiyatallah 
      University of Medical Sciences, Tehran, Iran.
FAU - Hofmeister, Martin
AU  - Hofmeister M
AD  - Department of Food and Nutrition, Consumer Centre of the German Federal State of 
      Bavaria, Munich, Germany.
LA  - eng
PT  - Journal Article
DEP - 20220721
PL  - Germany
TA  - EXCLI J
JT  - EXCLI journal
JID - 101299402
PMC - PMC9441685
OTO - NOTNLM
OT  - Lactobacillus rhamnosus GG
OT  - exercise training
OT  - fatty liver disease
OT  - probiotic
EDAT- 2022/09/17 06:00
MHDA- 2022/09/17 06:01
PMCR- 2022/07/21
CRDT- 2022/09/16 02:35
PHST- 2022/02/25 00:00 [received]
PHST- 2022/07/20 00:00 [accepted]
PHST- 2022/09/16 02:35 [entrez]
PHST- 2022/09/17 06:00 [pubmed]
PHST- 2022/09/17 06:01 [medline]
PHST- 2022/07/21 00:00 [pmc-release]
AID - 2022-4791 [pii]
AID - Doc991 [pii]
AID - 10.17179/excli2022-4791 [doi]
PST - epublish
SO  - EXCLI J. 2022 Jul 21;21:991-1006. doi: 10.17179/excli2022-4791. eCollection 2022.