PMID- 36112176 OWN - NLM STAT- MEDLINE DCOM- 20230529 LR - 20230529 IS - 1869-1447 (Electronic) IS - 1869-1439 (Print) IS - 1869-1439 (Linking) VI - 33 IP - 2 DP - 2023 Jun TI - White Matter Characteristics of Damage Along Fiber Tracts in Patients with Type 2 Diabetes Mellitus. PG - 327-341 LID - 10.1007/s00062-022-01213-7 [doi] AB - PURPOSE: The white matter (WM) of the brain of type 2 diabetes mellitus (T2DM) patients is susceptible to neurodegenerative processes, but the specific types and positions of microstructural lesions along the fiber tracts remain unclear. METHODS: In this study 61 T2DM patients and 61 healthy controls were recruited and underwent diffusion spectrum imaging (DSI). The results were reconstructed with diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI). WM microstructural abnormalities were identified using tract-based spatial statistics (TBSS). Pointwise WM tract differences were detected through automatic fiber quantification (AFQ). The relationships between WM tract abnormalities and clinical characteristics were explored with partial correlation analysis. RESULTS: TBSS revealed widespread WM lesions in T2DM patients with decreased fractional anisotropy and axial diffusivity and an increased orientation dispersion index (ODI). The AFQ results showed microstructural abnormalities in T2DM patients in specific portions of the right superior longitudinal fasciculus (SLF), right arcuate fasciculus (ARC), left anterior thalamic radiation (ATR), and forceps major (FMA). In the right ARC of T2DM patients, an aberrant ODI was positively correlated with fasting insulin and insulin resistance, and an abnormal intracellular volume fraction was negatively correlated with fasting blood glucose. Additionally, negative associations were found between blood pressure and microstructural abnormalities in the right ARC, left ATR, and FMA in T2DM patients. CONCLUSION: Using AFQ, together with DTI and NODDI, various kinds of microstructural alterations in the right SLF, right ARC, left ATR, and FMA can be accurately identified and may be associated with insulin and glucose status and blood pressure in T2DM patients. CI - (c) 2022. The Author(s). FAU - Huang, Haoming AU - Huang H AUID- ORCID: 0000-0003-2809-972X AD - The First Clinical Medical College, Guangzhou University of Chinese Medicine, 510405, Guangzhou, Guangdong, China. AD - Department of Radiology, The First Affiliated Hospital, Guangzhou University of Chinese Medicine, 510405, Guangzhou, Guangdong, China. FAU - Ma, Xiaomeng AU - Ma X AD - The First Clinical Medical College, Guangzhou University of Chinese Medicine, 510405, Guangzhou, Guangdong, China. AD - Department of Radiology, Jingzhou First People's Hospital of Hubei Province, 434000, Jingzhou, Hubei, China. FAU - Yue, Xiaomei AU - Yue X AD - The First Clinical Medical College, Guangzhou University of Chinese Medicine, 510405, Guangzhou, Guangdong, China. FAU - Kang, Shangyu AU - Kang S AD - The First Clinical Medical College, Guangzhou University of Chinese Medicine, 510405, Guangzhou, Guangdong, China. FAU - Li, Yifan AU - Li Y AD - The First Clinical Medical College, Guangzhou University of Chinese Medicine, 510405, Guangzhou, Guangdong, China. FAU - Rao, Yawen AU - Rao Y AD - The First Clinical Medical College, Guangzhou University of Chinese Medicine, 510405, Guangzhou, Guangdong, China. FAU - Feng, Yue AU - Feng Y AD - The First Clinical Medical College, Guangzhou University of Chinese Medicine, 510405, Guangzhou, Guangdong, China. AD - Department of Radiology, The Affiliated Hospital (Nanfang Hospital), Southern Medical University, 510515, Guangzhou, Guangdong, China. FAU - Wu, Jinjian AU - Wu J AD - The First Clinical Medical College, Guangzhou University of Chinese Medicine, 510405, Guangzhou, Guangdong, China. FAU - Long, Wenjie AU - Long W AD - Department of Geriatrics, The First Affiliated Hospital, Guangzhou University of Chinese Medicine, 510405, Guangzhou, Guangdong, China. FAU - Chen, Yuna AU - Chen Y AD - The First Clinical Medical College, Guangzhou University of Chinese Medicine, 510405, Guangzhou, Guangdong, China. AD - Department of Endocrinology, The First Affiliated Hospital, Guangzhou University of Chinese Medicine, 510405, Guangzhou, Guangdong, China. FAU - Lyu, Wenjiao AU - Lyu W AD - The First Clinical Medical College, Guangzhou University of Chinese Medicine, 510405, Guangzhou, Guangdong, China. FAU - Tan, Xin AU - Tan X AD - Department of Radiology, The First Affiliated Hospital, Guangzhou University of Chinese Medicine, 510405, Guangzhou, Guangdong, China. banzi00@126.com. FAU - Qiu, Shijun AU - Qiu S AD - Department of Radiology, The First Affiliated Hospital, Guangzhou University of Chinese Medicine, 510405, Guangzhou, Guangdong, China. qiu-sj@163.com. LA - eng GR - 81920108019/The Key International Cooperation Project of National Natural Science Foundation of China/ GR - A2021182/The Medical Scientific Research Foundation of Guangdong Province/ GR - 201813/Second Batch of National Traditional Chinese Medicine (TCM) Clinical Research Base Project/ GR - B2022108/The Medical Scientific Research Foundation of Guangdong Province/ PT - Journal Article DEP - 20220916 PL - Germany TA - Clin Neuroradiol JT - Clinical neuroradiology JID - 101526693 RN - 0 (Insulins) SB - IM MH - Humans MH - *White Matter/diagnostic imaging/pathology MH - Diffusion Tensor Imaging/methods MH - *Diabetes Mellitus, Type 2/complications/diagnostic imaging/pathology MH - Brain/diagnostic imaging/pathology MH - Anisotropy MH - *Insulins PMC - PMC10220145 OTO - NOTNLM OT - Automatic fiber quantification OT - Diffusion tensor imaging OT - Neurite orientation dispersion and density imaging OT - Tract-based spatial statistics OT - Type 2 diabetes mellitus COIS- H. Huang, X. Ma, X. Yue, S. Kang, Y. Li, Y. Rao, Y. Feng, J. Wu, W. Long, Y. Chen, W. Lyu, X. Tan, and S. Qiu declare that they have no competing interests. EDAT- 2022/09/17 06:00 MHDA- 2023/05/29 06:42 PMCR- 2022/09/16 CRDT- 2022/09/16 11:14 PHST- 2022/03/21 00:00 [received] PHST- 2022/08/06 00:00 [accepted] PHST- 2023/05/29 06:42 [medline] PHST- 2022/09/17 06:00 [pubmed] PHST- 2022/09/16 11:14 [entrez] PHST- 2022/09/16 00:00 [pmc-release] AID - 10.1007/s00062-022-01213-7 [pii] AID - 1213 [pii] AID - 10.1007/s00062-022-01213-7 [doi] PST - ppublish SO - Clin Neuroradiol. 2023 Jun;33(2):327-341. doi: 10.1007/s00062-022-01213-7. Epub 2022 Sep 16.