PMID- 36113089
OWN - NLM
STAT- MEDLINE
DCOM- 20240123
LR  - 20240202
IS  - 1531-1937 (Electronic)
IS  - 0897-1900 (Linking)
VI  - 37
IP  - 1
DP  - 2024 Feb
TI  - Safety and Efficacy of Early Post-Operative Intravenous Iron Replacement In 
      Patients With HeartMate III Left Ventricular Assist Device.
PG  - 100-103
LID - 10.1177/08971900221127500 [doi]
AB  - Background: While guidelines suggest intravenous (IV) iron to improve functional 
      status and quality of life (QoL) in patients with NYHA class II-III heart failure 
      (HF), continuous flow left ventricular assist device (CF-LVAD) recipients were 
      not included in early IV iron studies. Our study compared outcomes between 
      patients who did and did not receive IV iron during the index admission following 
      Abbott HeartMate III (HM 3) CF-LVAD placement. Methods: Thirty-three adult 
      patients with a HM3 placed at our institution who received early post-operative 
      IV iron (n = 20) or no IV iron replacement (n = 13) were compared. The co-primary 
      outcomes were mean change in quality of life (by the Minnesota Living with Heart 
      Failure Questionnaire [MLHFQ]) and 6-minute walk distance (6MWD) from baseline to 
      first >90 day clinic follow-up. Results: At first clinic follow-up there was no 
      significant difference between the IV iron and no-IV iron groups in MLHFQ (-27 +/- 
      38 vs -21 +/- 41, P = .8822) or 6MWD (360 +/- 740 vs 786 +/- 722, P = .208). 
      Conclusion: Patients receiving IV iron during index admission following HM3 
      implantation did not experience an improvement in quality of life or functional 
      capacity when compared to those who did not receive IV iron.
FAU - Vesper, Ryan M
AU  - Vesper RM
AUID- ORCID: 0000-0002-1601-6360
AD  - Department of Pharmacy, University of North Carolina Medical Center, Chapel Hill, 
      NC, USA. RINGGOLD: 2334
FAU - Kemp, Lauren
AU  - Kemp L
AD  - Department of Pharmacy, Cone Health Moses Cone Hospital, Greensboro, NC, USA. 
      RINGGOLD: 3618
FAU - Iyer, Prashanth
AU  - Iyer P
AUID- ORCID: 0000-0002-3401-2451
AD  - Department of Pharmacy, University of North Carolina Medical Center, Chapel Hill, 
      NC, USA. RINGGOLD: 2334
FAU - Granger, Katelynn
AU  - Granger K
AD  - Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA. 
      RINGGOLD: 2334
FAU - Doligalski, Christina T
AU  - Doligalski CT
AD  - Department of Pharmacy, University of North Carolina Medical Center, Chapel Hill, 
      NC, USA. RINGGOLD: 2334
FAU - Byku, Mirnela
AU  - Byku M
AD  - Department of Medicine, Division of Cardiology, University of North Carolina 
      Medical Center, Chapel Hill, NC, USA. RINGGOLD: 2334
FAU - Hollis, Ian B
AU  - Hollis IB
AD  - Department of Pharmacy, University of North Carolina Medical Center, Chapel Hill, 
      NC, USA. RINGGOLD: 2334
LA  - eng
PT  - Journal Article
DEP - 20220914
PL  - United States
TA  - J Pharm Pract
JT  - Journal of pharmacy practice
JID - 8900945
SB  - IM
MH  - Adult
MH  - Humans
MH  - Quality of Life
MH  - *Heart-Assist Devices/adverse effects
MH  - *Heart Failure/diagnosis/drug therapy/surgery
MH  - Treatment Outcome
OTO - NOTNLM
OT  - heart failure
OT  - heartmate
OT  - intravenous iron
OT  - iron deficiency
OT  - left ventricular assist device
COIS- Declaration of Conflicting InterestsThe author(s) declared no potential conflicts 
      of interest with respect to the research, authorship, and/or publication of this 
      article.
EDAT- 2022/09/17 06:00
MHDA- 2024/01/23 06:43
CRDT- 2022/09/16 17:23
PHST- 2024/01/23 06:43 [medline]
PHST- 2022/09/17 06:00 [pubmed]
PHST- 2022/09/16 17:23 [entrez]
AID - 10.1177/08971900221127500 [doi]
PST - ppublish
SO  - J Pharm Pract. 2024 Feb;37(1):100-103. doi: 10.1177/08971900221127500. Epub 2022 
      Sep 14.