PMID- 36113784
OWN - NLM
STAT- MEDLINE
DCOM- 20221102
LR  - 20221102
IS  - 1873-6351 (Electronic)
IS  - 0278-6915 (Linking)
VI  - 169
DP  - 2022 Nov
TI  - Prenatal, but not postnatal exposure to chlorpyrifos affects social behavior of 
      mice and the excitatory-inhibitory balance in a sex-dependent manner.
PG  - 113423
LID - S0278-6915(22)00621-4 [pii]
LID - 10.1016/j.fct.2022.113423 [doi]
AB  - The balance between excitatory and inhibitory neurotransmitters is essential for 
      proper brain development. An imbalance between these two systems has been 
      associated with neurodevelopmental disorders. On the other hand, literature also 
      associates the massive use of pesticides with the increase of these disorders, 
      with a particular focus on chlorpyrifos (CPF) a world-wide used organophosphate 
      pesticide. This study was aimed at assessing social autistic-like behaviors on 
      mice pre or postnatally exposed to CPF (0 or 1 mg/kg/day), in both sexes. In 
      prenatal exposure, C57BL/6J pregnant mice were exposed to CPF through the diet, 
      between gestational days (GD) 12 and 18, while a positive control group for some 
      autistic behaviors was exposed to valproic acid (VPA) on GD 12 and 13. To assess 
      postnatal exposure, C57BL/6J mice were orally exposed to the vehicle (corn oil) 
      or CPF, from postnatal days (PND) 10-15. Social behavior and gene expression 
      analysis were assessed on PND 45. Results showed social alterations only in males 
      prenatally treated. GABA system was upregulated in CPF-treated females, whereas 
      an increase in both systems was observed in both treated males. These findings 
      suggest that males are more sensitive to prenatal CPF exposure, favoring the sex 
      bias observed in ASD.
CI  - Copyright (c) 2022 Elsevier Ltd. All rights reserved.
FAU - Biosca-Brull, Judit
AU  - Biosca-Brull J
AD  - Universitat Rovira i Virgili, Research Group in Neurobehavior and Health 
      (NEUROLAB), Tarragona, Spain; Universitat Rovira i Virgili, Department of 
      Psychology and Research Center for Behavior Assessment (CRAMC), Tarragona, Spain; 
      Universitat Rovira i Virgili, Laboratory of Toxicology and Environmental Health 
      (TECNATOX), Reus, Spain. Electronic address: judit.biosca@urv.cat.
FAU - Guardia-Escote, Laia
AU  - Guardia-Escote L
AD  - Universitat Rovira i Virgili, Research Group in Neurobehavior and Health 
      (NEUROLAB), Tarragona, Spain; Universitat Rovira i Virgili, Department of 
      Psychology and Research Center for Behavior Assessment (CRAMC), Tarragona, Spain.
FAU - Blanco, Jordi
AU  - Blanco J
AD  - Universitat Rovira i Virgili, Research Group in Neurobehavior and Health 
      (NEUROLAB), Tarragona, Spain; Universitat Rovira i Virgili, Laboratory of 
      Toxicology and Environmental Health (TECNATOX), Reus, Spain; Universitat Rovira i 
      Virgili, Department of Basic Medical Sciences, Reus, Spain.
FAU - Basaure, Pia
AU  - Basaure P
AD  - Universitat Rovira i Virgili, Research Group in Neurobehavior and Health 
      (NEUROLAB), Tarragona, Spain.
FAU - Cabre, Maria
AU  - Cabre M
AD  - Universitat Rovira i Virgili, Research Group in Neurobehavior and Health 
      (NEUROLAB), Tarragona, Spain; Universitat Rovira i Virgili, Department of 
      Biochemistry and Biotechnology, Tarragona, Spain.
FAU - Sanchez-Santed, Fernando
AU  - Sanchez-Santed F
AD  - Department of Psychology, Health Research Center (CEINSA), Almeria University, 
      04120, Almeria, Spain.
FAU - Domingo, Jose L
AU  - Domingo JL
AD  - Universitat Rovira i Virgili, Laboratory of Toxicology and Environmental Health 
      (TECNATOX), Reus, Spain.
FAU - Colomina, Maria Teresa
AU  - Colomina MT
AD  - Universitat Rovira i Virgili, Research Group in Neurobehavior and Health 
      (NEUROLAB), Tarragona, Spain; Universitat Rovira i Virgili, Department of 
      Psychology and Research Center for Behavior Assessment (CRAMC), Tarragona, Spain; 
      Universitat Rovira i Virgili, Laboratory of Toxicology and Environmental Health 
      (TECNATOX), Reus, Spain. Electronic address: mariateresa.colomina@urv.cat.
LA  - eng
PT  - Journal Article
DEP - 20220913
PL  - England
TA  - Food Chem Toxicol
JT  - Food and chemical toxicology : an international journal published for the British 
      Industrial Biological Research Association
JID - 8207483
RN  - JCS58I644W (Chlorpyrifos)
RN  - 8001-30-7 (Corn Oil)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
RN  - 0 (Pesticides)
RN  - 614OI1Z5WI (Valproic Acid)
SB  - IM
MH  - Animals
MH  - Female
MH  - Humans
MH  - Male
MH  - Mice
MH  - Pregnancy
MH  - *Behavior, Animal/drug effects
MH  - *Chlorpyrifos/toxicity
MH  - Corn Oil
MH  - gamma-Aminobutyric Acid
MH  - Mice, Inbred C57BL
MH  - *Pesticides/toxicity
MH  - *Prenatal Exposure Delayed Effects
MH  - *Social Behavior
MH  - Valproic Acid/toxicity
MH  - Sex Factors
OTO - NOTNLM
OT  - Autism
OT  - Chlorpyrifos
OT  - Excitatory/inhibitory balance
OT  - GABA
OT  - Glutamate
OT  - Social behavior
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2022/09/17 06:00
MHDA- 2022/10/20 06:00
CRDT- 2022/09/16 19:27
PHST- 2022/08/12 00:00 [received]
PHST- 2022/08/26 00:00 [accepted]
PHST- 2022/09/17 06:00 [pubmed]
PHST- 2022/10/20 06:00 [medline]
PHST- 2022/09/16 19:27 [entrez]
AID - S0278-6915(22)00621-4 [pii]
AID - 10.1016/j.fct.2022.113423 [doi]
PST - ppublish
SO  - Food Chem Toxicol. 2022 Nov;169:113423. doi: 10.1016/j.fct.2022.113423. Epub 2022 
      Sep 13.