PMID- 36115135
OWN - NLM
STAT- MEDLINE
DCOM- 20221201
LR  - 20221205
IS  - 1095-6867 (Electronic)
IS  - 0018-506X (Linking)
VI  - 146
DP  - 2022 Nov
TI  - Estradiol and progesterone-induced lordosis behavior is modulated by both the 
      Kisspeptin receptor and melanin-concentrating hormone in estradiol 
      benzoate-primed rats.
PG  - 105257
LID - S0018-506X(22)00151-9 [pii]
LID - 10.1016/j.yhbeh.2022.105257 [doi]
AB  - Intracerebroventricular (ICV) administration of estradiol benzoate (E(2)B) and 
      progesterone (P) induces intense lordosis behavior in ovariectomized rats primed 
      peripherally with E(2)B. The present study tested the hypothesis that the 
      Kisspeptin (Kiss) and melanin-concentrating hormone (MCH) pathways regulate 
      female sexual behavior induced by these steroid hormones. In Experiment 1, we 
      tested the relevance of the Kiss pathway by ICV infusion of its inhibitor, 
      kiss-234, before administration of E(2)B or P in estrogen-primed rats. Lordosis 
      induced by E(2)B alone or with the addition of P was reduced significantly at 30, 
      120, and 240 min. In Experiment 2, ICV infusion of MCH 30 min before E(2)B or P 
      significantly reduced lordosis in rats primed with E(2)B alone. These data 
      support the hypothesis that the Kiss and MCH pathways, which can release or 
      modulate gonadotropin-releasing hormone (GnRH), are involved in E(2)B- and 
      P-induced lordosis.
CI  - Copyright (c) 2022 Elsevier Inc. All rights reserved.
FAU - Gonzalez-Flores, Oscar
AU  - Gonzalez-Flores O
AD  - Centro de Investigacion en Reproduccion Animal, Universidad Autonoma de 
      Tlaxcala-CINVESTAV, Tlaxcala, Mexico.
FAU - Pfaus, James G
AU  - Pfaus JG
AD  - Department of Psychology and Life Sciences, Charles University, Prague, Czech 
      Republic; Czech National Institute of Mental Health, Klecany, Czech Republic.
FAU - Luna-Hernandez, Ailyn
AU  - Luna-Hernandez A
AD  - Centro de Investigacion en Reproduccion Animal, Universidad Autonoma de 
      Tlaxcala-CINVESTAV, Tlaxcala, Mexico; Maestria en Ciencias Biologicas, 
      Universidad Autonoma de Tlaxcala, Tlaxcala, Mexico.
FAU - Montes-Narvaez, Omar
AU  - Montes-Narvaez O
AD  - Centro de Investigacion en Reproduccion Animal, Universidad Autonoma de 
      Tlaxcala-CINVESTAV, Tlaxcala, Mexico; Doctorado en Ciencias Biologicas, 
      Universidad Autonoma de Tlaxcala, Tlaxcala, Mexico.
FAU - Dominguez-Ordonez, Raymundo
AU  - Dominguez-Ordonez R
AD  - Centro de Investigacion en Reproduccion Animal, Universidad Autonoma de 
      Tlaxcala-CINVESTAV, Tlaxcala, Mexico; Licenciatura en Ingenieria Agronomica y 
      Zootecnia, CRC, Benemerita Universidad Autonoma de Puebla, Mexico.
FAU - Tecamachaltzi-Silvaran, Miriam B
AU  - Tecamachaltzi-Silvaran MB
AD  - Centro de Investigacion en Reproduccion Animal, Universidad Autonoma de 
      Tlaxcala-CINVESTAV, Tlaxcala, Mexico.
FAU - Garcia-Juarez, Marcos
AU  - Garcia-Juarez M
AD  - Centro de Investigacion en Reproduccion Animal, Universidad Autonoma de 
      Tlaxcala-CINVESTAV, Tlaxcala, Mexico. Electronic address: 
      garcia_juarez_marcos@yahoo.com.mx.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220914
PL  - United States
TA  - Horm Behav
JT  - Hormones and behavior
JID - 0217764
RN  - 4TI98Z838E (Estradiol)
RN  - 1S4CJB5ZGN (estradiol 3-benzoate)
RN  - 33515-09-2 (Gonadotropin-Releasing Hormone)
RN  - 0 (Kisspeptins)
RN  - 67382-96-1 (melanin-concentrating hormone)
RN  - 4G7DS2Q64Y (Progesterone)
SB  - IM
MH  - Animals
MH  - Female
MH  - Rats
MH  - Estradiol/pharmacology
MH  - Gonadotropin-Releasing Hormone/pharmacology
MH  - Kisspeptins/pharmacology
MH  - *Lordosis/chemically induced
MH  - Ovariectomy
MH  - *Progesterone/pharmacology
MH  - Sexual Behavior, Animal/physiology
OTO - NOTNLM
OT  - Estradiol
OT  - Kisspeptin
OT  - Lordosis
OT  - Melanin-concentrating hormone
OT  - Progesterone
EDAT- 2022/09/18 06:00
MHDA- 2022/12/01 06:00
CRDT- 2022/09/17 18:17
PHST- 2022/04/26 00:00 [received]
PHST- 2022/08/22 00:00 [revised]
PHST- 2022/08/30 00:00 [accepted]
PHST- 2022/09/18 06:00 [pubmed]
PHST- 2022/12/01 06:00 [medline]
PHST- 2022/09/17 18:17 [entrez]
AID - S0018-506X(22)00151-9 [pii]
AID - 10.1016/j.yhbeh.2022.105257 [doi]
PST - ppublish
SO  - Horm Behav. 2022 Nov;146:105257. doi: 10.1016/j.yhbeh.2022.105257. Epub 2022 Sep 
      14.