PMID- 36115950 OWN - NLM STAT- MEDLINE DCOM- 20220920 LR - 20220921 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 22 IP - 1 DP - 2022 Sep 17 TI - Adapting prenatal iron supplementation to maternal needs results in optimal child neurodevelopment: a follow-up of the ECLIPSES Study. PG - 710 LID - 10.1186/s12884-022-05033-y [doi] LID - 710 AB - BACKGROUND: Prenatal prescription of standard iron supplements to prevent iron deficiency appears not to be appropriate for all women and their children, as some women may be at risk of iron deficiency and others at risk of iron excess early in pregnancy. The present study aimed to assess whether prenatal iron supplementation adapted to the needs of each pregnant woman affects their child's neurodevelopment. METHODS: Follow-up of a community-based RCT involving 503 mother-child pairs. Non-anaemic pregnant women recruited in Tarragona (Spain) early in pregnancy were prescribed a daily iron dose based on their initial haemoglobin levels: Stratum 1 (Hb = 110-130 g/L, 80 or 40 mg/d of iron) and Stratum 2 (Hb > 130 g/L, 40 or 20 mg/d of iron). Women receiving 40 mg/d were considered the control group in each Strata. The child's neurodevelopment was assessed at 40 days of age using the Bayley Scales of Infant Development-III (BSID-III). Adjusted multiple regression models were used. RESULTS: Multiple regression analyses showed no association between the intervention and control group within each Strata on the BSID-III scores on any of the developmental scales in children, including cognitive, language, and motor development: Stratum 1 (beta 1.46, 95%CI -2.15, 5.07; beta 1.30, 95%CI -1.99, 4.59; and beta 2.04, 95%CI -3.88, 7.96, respectively) and Stratum 2 (beta -4.04, 95%CI -7.27, 0.80; beta -0.36, 95%CI -3.47, 2.75; and beta -3.76, 95%CI -9.30, 1.78, respectively). CONCLUSIONS: In non-anaemic women in early pregnancy, no differences were found in the cognitive, language and motor development of children at 40 days of age between the dose of iron tested in each case -adjusted to initial Hb levels- compared to the dose of the control group. Further studies are guaranteed to confirm our findings. TRIAL REGISTRATION: The ECLIPSES study was registered at www.clinicaltrialsregister.eu as EudraCT number 2012-005,480-28. CI - (c) 2022. The Author(s). FAU - Iglesias-Vazquez, Lucia AU - Iglesias-Vazquez L AUID- ORCID: 0000-0001-7131-4144 AD - Nutrition and Mental Health (NUTRISAM) Research Group, Universitat Rovira I Virgili, 43204, Reus, Spain. AD - Institut d'Investigacio Sanitaria Pere Virgili (IISPV), 43204, Reus, Spain. FAU - Hernandez-Martinez, Carmen AU - Hernandez-Martinez C AUID- ORCID: 0000-0001-6328-8679 AD - Nutrition and Mental Health (NUTRISAM) Research Group, Universitat Rovira I Virgili, 43204, Reus, Spain. AD - Department of Psychology, Research Centre for Behavioral Assessment (CRAMC), Faculty of Education Sciences and Psychology, Universitat Rovira I Virgili, 43007, Tarragona, Spain. FAU - Voltas, Nuria AU - Voltas N AUID- ORCID: 0000-0001-8855-0282 AD - Nutrition and Mental Health (NUTRISAM) Research Group, Universitat Rovira I Virgili, 43204, Reus, Spain. AD - Department of Psychology, Research Centre for Behavioral Assessment (CRAMC), Faculty of Education Sciences and Psychology, Universitat Rovira I Virgili, 43007, Tarragona, Spain. AD - Department of Psychology, Faculty of Education Sciences and Psychology, Serra Hunter Fellow, Universitat Rovira I Virgili, 43007, Tarragona, Spain. FAU - Canals, Josefa AU - Canals J AUID- ORCID: 0000-0002-6209-9558 AD - Nutrition and Mental Health (NUTRISAM) Research Group, Universitat Rovira I Virgili, 43204, Reus, Spain. AD - Department of Psychology, Research Centre for Behavioral Assessment (CRAMC), Faculty of Education Sciences and Psychology, Universitat Rovira I Virgili, 43007, Tarragona, Spain. FAU - Coronel, Pilar AU - Coronel P AD - Meiji Pharma SpainES (Formerly Tedec-Meiji Farma S.A, 228802, Alcala de Henares, Madrid, Spain. FAU - Gimeno, Mercedes AU - Gimeno M AD - Meiji Pharma SpainES (Formerly Tedec-Meiji Farma S.A, 228802, Alcala de Henares, Madrid, Spain. FAU - Arija, Victoria AU - Arija V AUID- ORCID: 0000-0002-1758-0975 AD - Nutrition and Mental Health (NUTRISAM) Research Group, Universitat Rovira I Virgili, 43204, Reus, Spain. victoria.arija@urv.cat. AD - Institut d'Investigacio Sanitaria Pere Virgili (IISPV), 43204, Reus, Spain. victoria.arija@urv.cat. AD - Collaborative Research Group On Lifestyles, Nutrition, and Smoking (CENIT). Tarragona-Reus Research Support Unit, IDIAP Jordi Gol, 43003, Tarragona, Spain. victoria.arija@urv.cat. LA - eng GR - PI12/02777/Instituto de Salud Carlos III/ PT - Journal Article DEP - 20220917 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 RN - 0 (Hemoglobins) RN - 0 (Vitamins) RN - E1UOL152H7 (Iron) SB - IM MH - *Anemia, Iron-Deficiency/prevention & control MH - Dietary Supplements MH - Female MH - Follow-Up Studies MH - Hemoglobins/analysis MH - Humans MH - Iron MH - Pregnancy MH - *Pregnancy Complications, Hematologic/prevention & control MH - Vitamins PMC - PMC9482254 OTO - NOTNLM OT - Cognitive development OT - Iron supplementation OT - Language development OT - Motor development OT - Neurodevelopment OT - Prenatal COIS- The authors state that they have no conflict of interest to declare. EDAT- 2022/09/18 06:00 MHDA- 2022/09/21 06:00 PMCR- 2022/09/17 CRDT- 2022/09/17 23:24 PHST- 2022/05/12 00:00 [received] PHST- 2022/08/10 00:00 [accepted] PHST- 2022/09/17 23:24 [entrez] PHST- 2022/09/18 06:00 [pubmed] PHST- 2022/09/21 06:00 [medline] PHST- 2022/09/17 00:00 [pmc-release] AID - 10.1186/s12884-022-05033-y [pii] AID - 5033 [pii] AID - 10.1186/s12884-022-05033-y [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2022 Sep 17;22(1):710. doi: 10.1186/s12884-022-05033-y.