PMID- 36116559
OWN - NLM
STAT- MEDLINE
DCOM- 20221206
LR  - 20221208
IS  - 1527-9995 (Electronic)
IS  - 0090-4295 (Linking)
VI  - 170
DP  - 2022 Dec
TI  - Transvaginal Photobiomodulation Improves Pain in Women with Pelvic Muscle 
      Tenderness and Interstitial Cystitis/Bladder Pain Syndrome: A Preliminary 
      Observational Study.
PG  - 14-20
LID - S0090-4295(22)00781-6 [pii]
LID - 10.1016/j.urology.2022.08.036 [doi]
AB  - PURPOSE: Interstitial Cystitis/ Bladder Pain Syndrome (IC/BPS) is characterized 
      by pelvic/bladder pain, associated with pelvic muscle tenderness, urgency, 
      frequency, and dysuria. Prior studies show that transvaginal photobiomodulation 
      (TV-PBM) reduces pain in women with chronic pelvic pain (CPP). Our objective was 
      to obtain preliminary data on treatment effect and adherence, in women with 
      IC/BPS who selected TV-PBM therapy for management of pelvic pain. MATERIALS AND 
      METHODS: Before-and-after observational cohort study of women with IC/BPS who 
      received TV-PBM in 17 US practices. Pain was measured using a 0-10 numeric rating 
      scale (NRS). The primary outcome was a minimal clinical important difference 
      (MCID); reduction of overall pelvic pain severity by >/=2 NRS points from baseline 
      compared to after 8 treatments. Cohen d coefficient measured effect size (low 
      effect size d<0.2, medium 0.2<d<0.8, and high d>0.8). RESULTS: Of 140 patients 
      with IC/BPS who self-selected to start TV-PBM therapy, 89.3% (n=125) completed 4 
      treatments and 59.3% (n=83) completed 8. Improvement >/=1 NRS point was reported by 
      73.5% (n=61) and meaningful improvement (>/=2 points) was reported by 63.9% (n=53) 
      after 8 treatments. In this group, patients with severe / moderate pain decreased 
      from 83.1% (n=44) to 38.5% (n=20); p<0.001. Pain levels decreased as follows: 
      overall pelvic pain MCID=-2.7, d=1.07, pain with urination MCID=-2.6, d=1.0; pain 
      with exercise MCID=-2.6, d=0.91, pain with intercourse MCID=-2.5, d=0.82. 
      CONCLUSION: In real-world clinical settings, 2/3 women with IC/BPS who opted to 
      undergo TV-PBM therapy reported significant decrease in pelvic pain and dysuria. 
      These findings are promising; however, controlled studies are needed.
CI  - Published by Elsevier Inc.
FAU - Butrick, Charles W
AU  - Butrick CW
AD  - Urogynecologist, Urogynecology of Kansas City, Kansas.
FAU - Lamvu, Georgine
AU  - Lamvu G
AD  - Professor of Obstetrics and Gynecology, University of Central Florida College of 
      Medicine, Orlando, Florida; Pelvic Pain Specialist, Orlando VA Healthcare System, 
      Orlando, Florida. Electronic address: Georgine.Lamvu@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20220915
PL  - United States
TA  - Urology
JT  - Urology
JID - 0366151
SB  - IM
MH  - Humans
MH  - Female
MH  - *Cystitis, Interstitial/complications/radiotherapy
MH  - Myalgia/complications
MH  - Dysuria
MH  - Pelvic Pain/radiotherapy/complications
MH  - Pelvis
EDAT- 2022/09/19 06:00
MHDA- 2022/12/07 06:00
CRDT- 2022/09/18 19:24
PHST- 2022/07/28 00:00 [received]
PHST- 2022/08/22 00:00 [accepted]
PHST- 2022/09/19 06:00 [pubmed]
PHST- 2022/12/07 06:00 [medline]
PHST- 2022/09/18 19:24 [entrez]
AID - S0090-4295(22)00781-6 [pii]
AID - 10.1016/j.urology.2022.08.036 [doi]
PST - ppublish
SO  - Urology. 2022 Dec;170:14-20. doi: 10.1016/j.urology.2022.08.036. Epub 2022 Sep 
      15.